JPS55149240A - Hydroxybenzoic acid derivative and its acid addition salt - Google Patents

Hydroxybenzoic acid derivative and its acid addition salt

Info

Publication number
JPS55149240A
JPS55149240A JP5661279A JP5661279A JPS55149240A JP S55149240 A JPS55149240 A JP S55149240A JP 5661279 A JP5661279 A JP 5661279A JP 5661279 A JP5661279 A JP 5661279A JP S55149240 A JPS55149240 A JP S55149240A
Authority
JP
Japan
Prior art keywords
lower alkyl
addition salt
hydroxybenzamide
reacting
hydroxybenzoic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP5661279A
Other languages
Japanese (ja)
Other versions
JPS6215064B2 (en
Inventor
Setsuo Fujii
Eizo Hattori
Mitsuteru Hirata
Nobuo Yokoo
Masahiko Nagakura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kowa Co Ltd
Original Assignee
Kowa Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kowa Co Ltd filed Critical Kowa Co Ltd
Priority to JP5661279A priority Critical patent/JPS55149240A/en
Publication of JPS55149240A publication Critical patent/JPS55149240A/en
Publication of JPS6215064B2 publication Critical patent/JPS6215064B2/ja
Granted legal-status Critical Current

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Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:The titled compound of formula I [R1 is (substituted) benzoyl, etc.; R2 is lower alkyl].
EXAMPLE: N-(2-Dimethylaminoethyl)-p-hydroxybenzamide.
USE: Remedy for pancreatic diseases of human and animals. Exhibits strong activity to inhibit protease especially chymotrypsin.
PROCESS: The compound I is prepared by (1) reacting a hydroxybenzoic acid ester II with an N,N-di-lower alkyl ethylenediamine under the conditions of ordinary acid amide synthesis, and (2) reacting the resulting N-(2-di-lower alkyl)aminoethyl hydroxybenzamide IV with a carboxylic acid V or its reactive derivative in th presence or absence of a condensing agent such as dicyclohexyl carbodiimide.
COPYRIGHT: (C)1980,JPO&Japio
JP5661279A 1979-05-09 1979-05-09 Hydroxybenzoic acid derivative and its acid addition salt Granted JPS55149240A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP5661279A JPS55149240A (en) 1979-05-09 1979-05-09 Hydroxybenzoic acid derivative and its acid addition salt

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5661279A JPS55149240A (en) 1979-05-09 1979-05-09 Hydroxybenzoic acid derivative and its acid addition salt

Publications (2)

Publication Number Publication Date
JPS55149240A true JPS55149240A (en) 1980-11-20
JPS6215064B2 JPS6215064B2 (en) 1987-04-06

Family

ID=13032064

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5661279A Granted JPS55149240A (en) 1979-05-09 1979-05-09 Hydroxybenzoic acid derivative and its acid addition salt

Country Status (1)

Country Link
JP (1) JPS55149240A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS595115A (en) * 1982-06-30 1984-01-12 Kowa Co Drug for treating diabetes

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS595115A (en) * 1982-06-30 1984-01-12 Kowa Co Drug for treating diabetes
JPH0231693B2 (en) * 1982-06-30 1990-07-16 Kowa Co

Also Published As

Publication number Publication date
JPS6215064B2 (en) 1987-04-06

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