JPS55167275A - Preparation of amidinophenyl ester derivative - Google Patents

Preparation of amidinophenyl ester derivative

Info

Publication number
JPS55167275A
JPS55167275A JP7549079A JP7549079A JPS55167275A JP S55167275 A JPS55167275 A JP S55167275A JP 7549079 A JP7549079 A JP 7549079A JP 7549079 A JP7549079 A JP 7549079A JP S55167275 A JPS55167275 A JP S55167275A
Authority
JP
Japan
Prior art keywords
formula
ester derivative
amidinophenyl
preparation
amidinophenyl ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP7549079A
Other languages
Japanese (ja)
Other versions
JPS6237622B2 (en
Inventor
Setsuo Fujii
Eizo Hattori
Mitsuteru Hirata
Hisashi Kunieda
Kazuhiro Onoki
Koichiro Watanabe
Masahiko Nagakura
Nobuo Yokoo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kowa Co Ltd
Original Assignee
Kowa Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kowa Co Ltd filed Critical Kowa Co Ltd
Priority to JP7549079A priority Critical patent/JPS55167275A/en
Publication of JPS55167275A publication Critical patent/JPS55167275A/en
Publication of JPS6237622B2 publication Critical patent/JPS6237622B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

NEW MATERIAL:An amidinophenyl ester derivative of formula I (R is heterocyclic group; A is single bond or lower alkylene group), and its acid addition salt.
EXAMPLE: 4'-Amidinophenyl furan-2-carboxylate.
USE: A proteolytic enzyme inhibitor having an inhibitory action on various proteolytic enzymes, e.g. chymotrypsin, trypsin or thrombin.
PROCESS: A heterocyclic carboxylic acid of formula II is esterified with an amidinophenol of formula III by conventional reaction to give an amidinophenyl ester derivative of formula I, which is converted into an inorganic acid salt, e.g. hydrochloride or sulfate, or an organic salt, e.g. acetate or maleate, by the conventional method.
COPYRIGHT: (C)1980,JPO&Japio
JP7549079A 1979-06-15 1979-06-15 Preparation of amidinophenyl ester derivative Granted JPS55167275A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP7549079A JPS55167275A (en) 1979-06-15 1979-06-15 Preparation of amidinophenyl ester derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7549079A JPS55167275A (en) 1979-06-15 1979-06-15 Preparation of amidinophenyl ester derivative

Publications (2)

Publication Number Publication Date
JPS55167275A true JPS55167275A (en) 1980-12-26
JPS6237622B2 JPS6237622B2 (en) 1987-08-13

Family

ID=13577769

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7549079A Granted JPS55167275A (en) 1979-06-15 1979-06-15 Preparation of amidinophenyl ester derivative

Country Status (1)

Country Link
JP (1) JPS55167275A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2540118A1 (en) * 1983-01-28 1984-08-03 Torii & Co Ltd NEW AMIDINES
US9346821B2 (en) 2011-06-07 2016-05-24 Ajinomoto Co., Inc. Heterocyclic carboxylic acid ester derivative

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5537198A (en) * 1978-09-07 1980-03-15 Beecham Group Ltd Enzyme derivative * production thereof and pharmaceutical composition containing same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5537198A (en) * 1978-09-07 1980-03-15 Beecham Group Ltd Enzyme derivative * production thereof and pharmaceutical composition containing same

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2540118A1 (en) * 1983-01-28 1984-08-03 Torii & Co Ltd NEW AMIDINES
US9346821B2 (en) 2011-06-07 2016-05-24 Ajinomoto Co., Inc. Heterocyclic carboxylic acid ester derivative

Also Published As

Publication number Publication date
JPS6237622B2 (en) 1987-08-13

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