JPS55167275A - Preparation of amidinophenyl ester derivative - Google Patents
Preparation of amidinophenyl ester derivativeInfo
- Publication number
- JPS55167275A JPS55167275A JP7549079A JP7549079A JPS55167275A JP S55167275 A JPS55167275 A JP S55167275A JP 7549079 A JP7549079 A JP 7549079A JP 7549079 A JP7549079 A JP 7549079A JP S55167275 A JPS55167275 A JP S55167275A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- ester derivative
- amidinophenyl
- preparation
- amidinophenyl ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
NEW MATERIAL:An amidinophenyl ester derivative of formula I (R is heterocyclic group; A is single bond or lower alkylene group), and its acid addition salt.
EXAMPLE: 4'-Amidinophenyl furan-2-carboxylate.
USE: A proteolytic enzyme inhibitor having an inhibitory action on various proteolytic enzymes, e.g. chymotrypsin, trypsin or thrombin.
PROCESS: A heterocyclic carboxylic acid of formula II is esterified with an amidinophenol of formula III by conventional reaction to give an amidinophenyl ester derivative of formula I, which is converted into an inorganic acid salt, e.g. hydrochloride or sulfate, or an organic salt, e.g. acetate or maleate, by the conventional method.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7549079A JPS55167275A (en) | 1979-06-15 | 1979-06-15 | Preparation of amidinophenyl ester derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7549079A JPS55167275A (en) | 1979-06-15 | 1979-06-15 | Preparation of amidinophenyl ester derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS55167275A true JPS55167275A (en) | 1980-12-26 |
JPS6237622B2 JPS6237622B2 (en) | 1987-08-13 |
Family
ID=13577769
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP7549079A Granted JPS55167275A (en) | 1979-06-15 | 1979-06-15 | Preparation of amidinophenyl ester derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55167275A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2540118A1 (en) * | 1983-01-28 | 1984-08-03 | Torii & Co Ltd | NEW AMIDINES |
US9346821B2 (en) | 2011-06-07 | 2016-05-24 | Ajinomoto Co., Inc. | Heterocyclic carboxylic acid ester derivative |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5537198A (en) * | 1978-09-07 | 1980-03-15 | Beecham Group Ltd | Enzyme derivative * production thereof and pharmaceutical composition containing same |
-
1979
- 1979-06-15 JP JP7549079A patent/JPS55167275A/en active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5537198A (en) * | 1978-09-07 | 1980-03-15 | Beecham Group Ltd | Enzyme derivative * production thereof and pharmaceutical composition containing same |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2540118A1 (en) * | 1983-01-28 | 1984-08-03 | Torii & Co Ltd | NEW AMIDINES |
US9346821B2 (en) | 2011-06-07 | 2016-05-24 | Ajinomoto Co., Inc. | Heterocyclic carboxylic acid ester derivative |
Also Published As
Publication number | Publication date |
---|---|
JPS6237622B2 (en) | 1987-08-13 |
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