JPS5697266A - Proline derivative and its preparation - Google Patents

Proline derivative and its preparation

Info

Publication number
JPS5697266A
JPS5697266A JP17382279A JP17382279A JPS5697266A JP S5697266 A JPS5697266 A JP S5697266A JP 17382279 A JP17382279 A JP 17382279A JP 17382279 A JP17382279 A JP 17382279A JP S5697266 A JPS5697266 A JP S5697266A
Authority
JP
Japan
Prior art keywords
proline
formula
derivative
proline derivative
benzyl ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP17382279A
Other languages
Japanese (ja)
Inventor
Naoto Yoneda
Joji Kato
Keizo Kinashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Seiyaku Co Ltd
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Priority to JP17382279A priority Critical patent/JPS5697266A/en
Publication of JPS5697266A publication Critical patent/JPS5697266A/en
Pending legal-status Critical Current

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  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A proline derivative expressed by formula I (R1 is lower alkyl) or a pharmacologically acceptable salt thereof.
EXAMPLE: N-[N-Ethyl-N-(N-hydroxycarbamoylmethyl)carbamoyl]-L-proline.
USE: A hypotensive agent having improved inhibitory action on an angiotensin converting enzyme.
PROCESS: A proline benzyl ester is reacted with phosgene to give benzyl ester of an N-chlorocarbonylproline, which is then condensed with a hydroxamic acid derivative of formula II. The resultant proline derivative of formula III is further catalytically reduced to give the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
JP17382279A 1979-12-28 1979-12-28 Proline derivative and its preparation Pending JPS5697266A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP17382279A JPS5697266A (en) 1979-12-28 1979-12-28 Proline derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP17382279A JPS5697266A (en) 1979-12-28 1979-12-28 Proline derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS5697266A true JPS5697266A (en) 1981-08-05

Family

ID=15967785

Family Applications (1)

Application Number Title Priority Date Filing Date
JP17382279A Pending JPS5697266A (en) 1979-12-28 1979-12-28 Proline derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5697266A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0061684A1 (en) * 1981-03-23 1982-10-06 Merck & Co. Inc. Urea compounds as antihypertensives
US4804676A (en) * 1984-10-04 1989-02-14 Sankyo Company Limited Enkephalinase B inhibitors, their preparation, and pharmaceutical compositions containing the same
WO2001044178A1 (en) * 1999-12-17 2001-06-21 Versicor, Inc. Novel urea compounds, compositions and methods of use and preparation
US6797820B2 (en) 1999-12-17 2004-09-28 Vicuron Pharmaceuticals Inc. Succinate compounds, compositions and methods of use and preparation
US6852752B2 (en) * 1999-12-17 2005-02-08 Vicuron Pharmaceuticals Inc. Urea compounds, compositions and methods of use and preparation

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0061684A1 (en) * 1981-03-23 1982-10-06 Merck & Co. Inc. Urea compounds as antihypertensives
US4804676A (en) * 1984-10-04 1989-02-14 Sankyo Company Limited Enkephalinase B inhibitors, their preparation, and pharmaceutical compositions containing the same
WO2001044178A1 (en) * 1999-12-17 2001-06-21 Versicor, Inc. Novel urea compounds, compositions and methods of use and preparation
US6797820B2 (en) 1999-12-17 2004-09-28 Vicuron Pharmaceuticals Inc. Succinate compounds, compositions and methods of use and preparation
US6852752B2 (en) * 1999-12-17 2005-02-08 Vicuron Pharmaceuticals Inc. Urea compounds, compositions and methods of use and preparation

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