JPS5651450A - Halogen-substituted proline derivative and its preparation - Google Patents

Halogen-substituted proline derivative and its preparation

Info

Publication number
JPS5651450A
JPS5651450A JP12637979A JP12637979A JPS5651450A JP S5651450 A JPS5651450 A JP S5651450A JP 12637979 A JP12637979 A JP 12637979A JP 12637979 A JP12637979 A JP 12637979A JP S5651450 A JPS5651450 A JP S5651450A
Authority
JP
Japan
Prior art keywords
halogen
formula
expressed
preparation
substituted proline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP12637979A
Other languages
Japanese (ja)
Inventor
Nobuyuki Fukazawa
Isao Kataue
Atsushi Kojima
Takashi Nishina
Takashi Kitano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsui Toatsu Chemicals Inc
Original Assignee
Mitsui Toatsu Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Toatsu Chemicals Inc filed Critical Mitsui Toatsu Chemicals Inc
Priority to JP12637979A priority Critical patent/JPS5651450A/en
Publication of JPS5651450A publication Critical patent/JPS5651450A/en
Pending legal-status Critical Current

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  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound expressed by formula I (R1 is H or lower alkanoyl; R2 is OH, lower alkoxyl, phenoxy or benzyloxy;X is halogen) or a salt thereof.
EXAMPLE: Benzyl ester of 1-(3-acetylthio-2-methylpropanoyl)-4- chloro-L-proline.
USE: A treating agent for hypertension having a hypotensive effect.
PROCESS: A halogen-substituted proline derivative expressed by formula II, is reacted with a reactive derivative of carboxylinc acid expressed by formula III, in a solvent, e.g. chloroform, at 0W100°C, to give a compound expressed by formula I (R1 is lower alkanoyl;R2 is lower alkoxyl, phenoxy or benzyloxy). This reaction may be carried out in the presence of a base, e.g. HnOH.
COPYRIGHT: (C)1981,JPO&Japio
JP12637979A 1979-10-02 1979-10-02 Halogen-substituted proline derivative and its preparation Pending JPS5651450A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12637979A JPS5651450A (en) 1979-10-02 1979-10-02 Halogen-substituted proline derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12637979A JPS5651450A (en) 1979-10-02 1979-10-02 Halogen-substituted proline derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS5651450A true JPS5651450A (en) 1981-05-09

Family

ID=14933693

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12637979A Pending JPS5651450A (en) 1979-10-02 1979-10-02 Halogen-substituted proline derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5651450A (en)

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