JPS57167964A - Preparation of (4r)-3-substituted-4-(substituted or unsubstituted carboxymethyl)-2-azetidinone derivative - Google Patents

Preparation of (4r)-3-substituted-4-(substituted or unsubstituted carboxymethyl)-2-azetidinone derivative

Info

Publication number
JPS57167964A
JPS57167964A JP56052464A JP5246481A JPS57167964A JP S57167964 A JPS57167964 A JP S57167964A JP 56052464 A JP56052464 A JP 56052464A JP 5246481 A JP5246481 A JP 5246481A JP S57167964 A JPS57167964 A JP S57167964A
Authority
JP
Japan
Prior art keywords
substituted
formula
azetidinone derivative
unsubstituted carboxymethyl
carboxymethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56052464A
Other languages
Japanese (ja)
Inventor
Miwako Komatsu
Yuichi Ochiai
Isamu Saikawa
Tetsuo Santo
Isamu Takakura
Shuntaro Takano
Kiyoshi Tanaka
Original Assignee
Toyama Chem Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chem Co Ltd filed Critical Toyama Chem Co Ltd
Priority to JP56052464A priority Critical patent/JPS57167964A/en
Publication of JPS57167964A publication Critical patent/JPS57167964A/en
Granted legal-status Critical Current

Links

Classifications

    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

PURPOSE: To prepare the titled compound useful as an intermediate of pharmaceuticals, in one step, in high yield, by reacting a (4S)-4-(substituted or unsubstituted carboxymethyl)-2-azetidinone derivative with a specific reaction reagent in the presence of a base.
CONSTITUTION: The objective compound of formula III[R1 is H, salt-forming cation, etc.; R2 is protecting group; R7 is group of formula -COR6 or -CR5R9R10 (R5 is alkyl, etc.; R6 is H, etc.; R9 and R10 are H, alkyl, etc.; R9 and R10 may together with adjacent C atom form a salt)]can be prepared by reactig a (4S)-4- (substituted or unsubstituted carboxymethyl)-2-azetidinone derivative of formulaI with a reaction reagent selected from the compounds of formula II, formula R5X (X is reactive group) and formula R6COY (Y is reactive group), in the presence of a base, and if necessary, eliminating or introducing or chlorinating the carboxyl protecting group of R1.
COPYRIGHT: (C)1982,JPO&Japio
JP56052464A 1981-04-09 1981-04-09 Preparation of (4r)-3-substituted-4-(substituted or unsubstituted carboxymethyl)-2-azetidinone derivative Granted JPS57167964A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP56052464A JPS57167964A (en) 1981-04-09 1981-04-09 Preparation of (4r)-3-substituted-4-(substituted or unsubstituted carboxymethyl)-2-azetidinone derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56052464A JPS57167964A (en) 1981-04-09 1981-04-09 Preparation of (4r)-3-substituted-4-(substituted or unsubstituted carboxymethyl)-2-azetidinone derivative

Publications (1)

Publication Number Publication Date
JPS57167964A true JPS57167964A (en) 1982-10-16

Family

ID=12915434

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56052464A Granted JPS57167964A (en) 1981-04-09 1981-04-09 Preparation of (4r)-3-substituted-4-(substituted or unsubstituted carboxymethyl)-2-azetidinone derivative

Country Status (1)

Country Link
JP (1) JPS57167964A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58118564A (en) * 1981-12-30 1983-07-14 Richter Gedeon Vegyeszet Novel heterocyclic acetic acid derivative
JPS58118566A (en) * 1981-12-30 1983-07-14 Richter Gedeon Vegyeszet Novel heterocyclic acetic acid derivative and manufacture
JPS5946265A (en) * 1982-08-24 1984-03-15 Sankyo Co Ltd Azetidinone derivative and its preparation
FR2549052A1 (en) * 1983-06-23 1985-01-18 Richter Gedeon Vegyeszet Diastereomeric derivatives of 4-oxo-2 azetidinyl-acetic acid

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56108785A (en) * 1979-04-27 1981-08-28 Merck & Co Inc Manufacture of 33*11hydroxyethyl**azetidinone

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56108785A (en) * 1979-04-27 1981-08-28 Merck & Co Inc Manufacture of 33*11hydroxyethyl**azetidinone

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58118564A (en) * 1981-12-30 1983-07-14 Richter Gedeon Vegyeszet Novel heterocyclic acetic acid derivative
JPS58118566A (en) * 1981-12-30 1983-07-14 Richter Gedeon Vegyeszet Novel heterocyclic acetic acid derivative and manufacture
JPS5946265A (en) * 1982-08-24 1984-03-15 Sankyo Co Ltd Azetidinone derivative and its preparation
JPH0129185B2 (en) * 1982-08-24 1989-06-08 Sankyo Co
FR2549052A1 (en) * 1983-06-23 1985-01-18 Richter Gedeon Vegyeszet Diastereomeric derivatives of 4-oxo-2 azetidinyl-acetic acid
JPS6056955A (en) * 1983-06-23 1985-04-02 Richter Gedeon Vegyeszet Heterocyclic acetic acid ester

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