JPS5579366A - Preparation of 2-aminoindolenine - Google Patents

Preparation of 2-aminoindolenine

Info

Publication number
JPS5579366A
JPS5579366A JP15096178A JP15096178A JPS5579366A JP S5579366 A JPS5579366 A JP S5579366A JP 15096178 A JP15096178 A JP 15096178A JP 15096178 A JP15096178 A JP 15096178A JP S5579366 A JPS5579366 A JP S5579366A
Authority
JP
Japan
Prior art keywords
formula
aminoindolenine
derivative
propionic acid
acylamidoalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP15096178A
Other languages
Japanese (ja)
Inventor
Fumio Sakiyama
Takashi Nakazawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Chemical Industry Co Ltd
Original Assignee
Asahi Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Chemical Industry Co Ltd filed Critical Asahi Chemical Industry Co Ltd
Priority to JP15096178A priority Critical patent/JPS5579366A/en
Publication of JPS5579366A publication Critical patent/JPS5579366A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:An 2-aminoindolenine derivative of formula I: (R is H, ω-carboxyalkyl, ω-carboxy-ω-acylamidoalkyl, or ω-alkoxycarbonyl-ω-acylamidoalkyl group).
EXAMPLE: 3-(2-Amino-3-hydroxy-3-indolenyl)propionic acid.
USE: An intermediate for the synthesis of medicines, having analgesic, anti-inflammatory, antihistamine, cardiac vasodilator, diuretic, and hypoglycemic actions.
PROCESS: An N-formylaniline derivative of formula II, e.g. 3-(O-formamidobenzoyl) propionic acid, is reacted with an alkali metal cyanide, e.g. KCN, in a solvent, e.g. water alone or its mixture with a miscible solvent, at an optimum pH to form the objective compound of formula I simply, safely, and efficiently.
COPYRIGHT: (C)1980,JPO&Japio
JP15096178A 1978-12-08 1978-12-08 Preparation of 2-aminoindolenine Pending JPS5579366A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15096178A JPS5579366A (en) 1978-12-08 1978-12-08 Preparation of 2-aminoindolenine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15096178A JPS5579366A (en) 1978-12-08 1978-12-08 Preparation of 2-aminoindolenine

Publications (1)

Publication Number Publication Date
JPS5579366A true JPS5579366A (en) 1980-06-14

Family

ID=15508209

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15096178A Pending JPS5579366A (en) 1978-12-08 1978-12-08 Preparation of 2-aminoindolenine

Country Status (1)

Country Link
JP (1) JPS5579366A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8980926B2 (en) 2009-10-30 2015-03-17 Genzyme Corporation 2-aminoindole compounds and methods for the treatment of malaria

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8980926B2 (en) 2009-10-30 2015-03-17 Genzyme Corporation 2-aminoindole compounds and methods for the treatment of malaria

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