JPS5579366A - Preparation of 2-aminoindolenine - Google Patents
Preparation of 2-aminoindolenineInfo
- Publication number
- JPS5579366A JPS5579366A JP15096178A JP15096178A JPS5579366A JP S5579366 A JPS5579366 A JP S5579366A JP 15096178 A JP15096178 A JP 15096178A JP 15096178 A JP15096178 A JP 15096178A JP S5579366 A JPS5579366 A JP S5579366A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- aminoindolenine
- derivative
- propionic acid
- acylamidoalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:An 2-aminoindolenine derivative of formula I: (R is H, ω-carboxyalkyl, ω-carboxy-ω-acylamidoalkyl, or ω-alkoxycarbonyl-ω-acylamidoalkyl group).
EXAMPLE: 3-(2-Amino-3-hydroxy-3-indolenyl)propionic acid.
USE: An intermediate for the synthesis of medicines, having analgesic, anti-inflammatory, antihistamine, cardiac vasodilator, diuretic, and hypoglycemic actions.
PROCESS: An N-formylaniline derivative of formula II, e.g. 3-(O-formamidobenzoyl) propionic acid, is reacted with an alkali metal cyanide, e.g. KCN, in a solvent, e.g. water alone or its mixture with a miscible solvent, at an optimum pH to form the objective compound of formula I simply, safely, and efficiently.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15096178A JPS5579366A (en) | 1978-12-08 | 1978-12-08 | Preparation of 2-aminoindolenine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15096178A JPS5579366A (en) | 1978-12-08 | 1978-12-08 | Preparation of 2-aminoindolenine |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5579366A true JPS5579366A (en) | 1980-06-14 |
Family
ID=15508209
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15096178A Pending JPS5579366A (en) | 1978-12-08 | 1978-12-08 | Preparation of 2-aminoindolenine |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5579366A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8980926B2 (en) | 2009-10-30 | 2015-03-17 | Genzyme Corporation | 2-aminoindole compounds and methods for the treatment of malaria |
-
1978
- 1978-12-08 JP JP15096178A patent/JPS5579366A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8980926B2 (en) | 2009-10-30 | 2015-03-17 | Genzyme Corporation | 2-aminoindole compounds and methods for the treatment of malaria |
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