JPS572271A - Preparation of 2-aminoindolenine derivative - Google Patents
Preparation of 2-aminoindolenine derivativeInfo
- Publication number
- JPS572271A JPS572271A JP7440480A JP7440480A JPS572271A JP S572271 A JPS572271 A JP S572271A JP 7440480 A JP7440480 A JP 7440480A JP 7440480 A JP7440480 A JP 7440480A JP S572271 A JPS572271 A JP S572271A
- Authority
- JP
- Japan
- Prior art keywords
- acylamidealkyl
- formula
- compound
- amino
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
NEW MATERIAL:The compound of formula I (R is H, ω-carboxyalkyl, ω-carboxy- ω-acylamidealkyl, ω-acylamidealkyl, or ω-alkoxycarbonyl-ω-acylamidealkyl; R" is H or OCH3).
EXAMPLE: N-(2-amino-3-hydroxy-5-methoxy-3H-indol-3-yl)-ethylacetamide.
USE: Since the 2-position amino group and the 3-position OH group can be modified to obtain various derivatives, the present compound is useful as an intermediate for the synthesis of pharmaceuticals. The pharmacological activities such as analgesic, antiphlogistic, antihistamic, cardiac vessel dilating, diuretic and blood sugar level depressing activities, are expected.
PROCESS: The compound of formula I can be prepared, extremely easily, safely, in high efficiency, by reacting an N-acylaniline derivative of formula II (R' is H, CF3, alkyl, aryl, or alkoxyl) with an alkali metal cyanate in a nonaqueous solvent in the presence of an amino acid or an organic primary amine salt.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7440480A JPS572271A (en) | 1980-06-04 | 1980-06-04 | Preparation of 2-aminoindolenine derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7440480A JPS572271A (en) | 1980-06-04 | 1980-06-04 | Preparation of 2-aminoindolenine derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS572271A true JPS572271A (en) | 1982-01-07 |
JPH0248544B2 JPH0248544B2 (en) | 1990-10-25 |
Family
ID=13546209
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP7440480A Granted JPS572271A (en) | 1980-06-04 | 1980-06-04 | Preparation of 2-aminoindolenine derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS572271A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2493305A4 (en) * | 2009-10-30 | 2013-04-24 | Genzyme Corp | 2-aminoindole compounds and methods for the treatment of malaria |
-
1980
- 1980-06-04 JP JP7440480A patent/JPS572271A/en active Granted
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2493305A4 (en) * | 2009-10-30 | 2013-04-24 | Genzyme Corp | 2-aminoindole compounds and methods for the treatment of malaria |
US8980926B2 (en) | 2009-10-30 | 2015-03-17 | Genzyme Corporation | 2-aminoindole compounds and methods for the treatment of malaria |
Also Published As
Publication number | Publication date |
---|---|
JPH0248544B2 (en) | 1990-10-25 |
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