JPS572271A - Preparation of 2-aminoindolenine derivative - Google Patents

Preparation of 2-aminoindolenine derivative

Info

Publication number
JPS572271A
JPS572271A JP7440480A JP7440480A JPS572271A JP S572271 A JPS572271 A JP S572271A JP 7440480 A JP7440480 A JP 7440480A JP 7440480 A JP7440480 A JP 7440480A JP S572271 A JPS572271 A JP S572271A
Authority
JP
Japan
Prior art keywords
acylamidealkyl
formula
compound
amino
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP7440480A
Other languages
Japanese (ja)
Other versions
JPH0248544B2 (en
Inventor
Fumio Sakiyama
Takashi Nakazawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Chemical Industry Co Ltd
Original Assignee
Asahi Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Chemical Industry Co Ltd filed Critical Asahi Chemical Industry Co Ltd
Priority to JP7440480A priority Critical patent/JPS572271A/en
Publication of JPS572271A publication Critical patent/JPS572271A/en
Publication of JPH0248544B2 publication Critical patent/JPH0248544B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

NEW MATERIAL:The compound of formula I (R is H, ω-carboxyalkyl, ω-carboxy- ω-acylamidealkyl, ω-acylamidealkyl, or ω-alkoxycarbonyl-ω-acylamidealkyl; R" is H or OCH3).
EXAMPLE: N-(2-amino-3-hydroxy-5-methoxy-3H-indol-3-yl)-ethylacetamide.
USE: Since the 2-position amino group and the 3-position OH group can be modified to obtain various derivatives, the present compound is useful as an intermediate for the synthesis of pharmaceuticals. The pharmacological activities such as analgesic, antiphlogistic, antihistamic, cardiac vessel dilating, diuretic and blood sugar level depressing activities, are expected.
PROCESS: The compound of formula I can be prepared, extremely easily, safely, in high efficiency, by reacting an N-acylaniline derivative of formula II (R' is H, CF3, alkyl, aryl, or alkoxyl) with an alkali metal cyanate in a nonaqueous solvent in the presence of an amino acid or an organic primary amine salt.
COPYRIGHT: (C)1982,JPO&Japio
JP7440480A 1980-06-04 1980-06-04 Preparation of 2-aminoindolenine derivative Granted JPS572271A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP7440480A JPS572271A (en) 1980-06-04 1980-06-04 Preparation of 2-aminoindolenine derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7440480A JPS572271A (en) 1980-06-04 1980-06-04 Preparation of 2-aminoindolenine derivative

Publications (2)

Publication Number Publication Date
JPS572271A true JPS572271A (en) 1982-01-07
JPH0248544B2 JPH0248544B2 (en) 1990-10-25

Family

ID=13546209

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7440480A Granted JPS572271A (en) 1980-06-04 1980-06-04 Preparation of 2-aminoindolenine derivative

Country Status (1)

Country Link
JP (1) JPS572271A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2493305A4 (en) * 2009-10-30 2013-04-24 Genzyme Corp 2-aminoindole compounds and methods for the treatment of malaria

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2493305A4 (en) * 2009-10-30 2013-04-24 Genzyme Corp 2-aminoindole compounds and methods for the treatment of malaria
US8980926B2 (en) 2009-10-30 2015-03-17 Genzyme Corporation 2-aminoindole compounds and methods for the treatment of malaria

Also Published As

Publication number Publication date
JPH0248544B2 (en) 1990-10-25

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