JPS5533433A - Production of 6-nucleoside derivative - Google Patents

Production of 6-nucleoside derivative

Info

Publication number
JPS5533433A
JPS5533433A JP10625478A JP10625478A JPS5533433A JP S5533433 A JPS5533433 A JP S5533433A JP 10625478 A JP10625478 A JP 10625478A JP 10625478 A JP10625478 A JP 10625478A JP S5533433 A JPS5533433 A JP S5533433A
Authority
JP
Japan
Prior art keywords
formula
chloropurine
ribofuranosyl
effected
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10625478A
Other languages
Japanese (ja)
Other versions
JPS5728719B2 (en
Inventor
Sada Miyasaka
Hiroshi Suemune
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamasa Shoyu KK
Original Assignee
Yamasa Shoyu KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamasa Shoyu KK filed Critical Yamasa Shoyu KK
Priority to JP10625478A priority Critical patent/JPS5533433A/en
Publication of JPS5533433A publication Critical patent/JPS5533433A/en
Publication of JPS5728719B2 publication Critical patent/JPS5728719B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Saccharide Compounds (AREA)

Abstract

PURPOSE: The reaction of a specific 9-β-D-ribofuranosyl-6-chloropurine with a carboxylic ester is effected in the presence of a base to produce readily title compound useful as synthetic intermediate of antitumorigenic agent.
CONSTITUTION: The reaction between 9-β-D-ribofuranosyl-6-chloropurine of formula I (Y, Z are H, protecting groups) and a carboxylic ester of formula II (R1 is alkyl, OR2; R2 is alkyl, aralkyl) is effected in a solvent of dimethylsulfoxide, hexamethyl phosphoroamide in the presence of a base as sodium hydroxide, n-butyl lithium at a temperature of room temperature to refluxing one, preferably under anhydrous conditions, to produce of 2-(9-β-D-ribofuranosylpurine-6-yl) acetate or its derivative of formula III (R3 is H, COOR2).
COPYRIGHT: (C)1980,JPO&Japio
JP10625478A 1978-09-01 1978-09-01 Production of 6-nucleoside derivative Granted JPS5533433A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10625478A JPS5533433A (en) 1978-09-01 1978-09-01 Production of 6-nucleoside derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10625478A JPS5533433A (en) 1978-09-01 1978-09-01 Production of 6-nucleoside derivative

Publications (2)

Publication Number Publication Date
JPS5533433A true JPS5533433A (en) 1980-03-08
JPS5728719B2 JPS5728719B2 (en) 1982-06-18

Family

ID=14428958

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10625478A Granted JPS5533433A (en) 1978-09-01 1978-09-01 Production of 6-nucleoside derivative

Country Status (1)

Country Link
JP (1) JPS5533433A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5758664A (en) * 1980-09-24 1982-04-08 Otsuka Pharmaceut Co Ltd Alkanoic acid derivative
JP2008140727A (en) * 2006-12-05 2008-06-19 Yazaki Corp Wiring tool for led, led pressure bonding unit, and wiring unit with led

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5758664A (en) * 1980-09-24 1982-04-08 Otsuka Pharmaceut Co Ltd Alkanoic acid derivative
JP2008140727A (en) * 2006-12-05 2008-06-19 Yazaki Corp Wiring tool for led, led pressure bonding unit, and wiring unit with led

Also Published As

Publication number Publication date
JPS5728719B2 (en) 1982-06-18

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