JPS55118452A - Production of alpha-cyanopropionic ester derivative - Google Patents
Production of alpha-cyanopropionic ester derivativeInfo
- Publication number
- JPS55118452A JPS55118452A JP2718779A JP2718779A JPS55118452A JP S55118452 A JPS55118452 A JP S55118452A JP 2718779 A JP2718779 A JP 2718779A JP 2718779 A JP2718779 A JP 2718779A JP S55118452 A JPS55118452 A JP S55118452A
- Authority
- JP
- Japan
- Prior art keywords
- ester derivative
- cyanopropionic
- formula
- alpha
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: N,N-Dimethylformamide amidedimethylacetal is used as a C-methylation reagent for a cyanoacetic ester derivative to produce safely title compound useful as synthetic intermediate of anti-inflammatory, analgesic, antipyretic or others.
CONSTITUTION: A cyanoacetic ester derivative of formula I (R1 is 4-isobutylphenyl, 3-benzoylphenyl, 6-methoxy-2-naphthyl; R2 is 1W3C lower alkyl) is made to react with N,N-dimethylformamide amidedimethylacetal of formula II in an amount of 1W2 times molar quantity of the cyanoacetic ester to produce α-cyanopropionic ester derivative of formula III. The reaction is effected in an inert organic solvent at 50W100°C for 1W5hr.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2718779A JPS55118452A (en) | 1979-03-06 | 1979-03-06 | Production of alpha-cyanopropionic ester derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2718779A JPS55118452A (en) | 1979-03-06 | 1979-03-06 | Production of alpha-cyanopropionic ester derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS55118452A true JPS55118452A (en) | 1980-09-11 |
JPS629106B2 JPS629106B2 (en) | 1987-02-26 |
Family
ID=12214065
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2718779A Granted JPS55118452A (en) | 1979-03-06 | 1979-03-06 | Production of alpha-cyanopropionic ester derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55118452A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62190097A (en) * | 1985-12-20 | 1987-08-20 | ウイスコンシン・アルムナイ・リサ−チ・フアウンデイシヨン | Production of (s)-alpha-methylaryl acetate |
-
1979
- 1979-03-06 JP JP2718779A patent/JPS55118452A/en active Granted
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62190097A (en) * | 1985-12-20 | 1987-08-20 | ウイスコンシン・アルムナイ・リサ−チ・フアウンデイシヨン | Production of (s)-alpha-methylaryl acetate |
JP2509200B2 (en) * | 1985-12-20 | 1996-06-19 | ウイスコンシン・アルムナイ・リサ−チ・フアウンデイシヨン | Method for producing (S) -α-methylarylacetic acid |
Also Published As
Publication number | Publication date |
---|---|
JPS629106B2 (en) | 1987-02-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS5278848A (en) | Preparation of novel propionic acid ester derivatives | |
JPS5576829A (en) | Beta,gamma-dihydropolyprenyl alcohol and hypotensive agent made from it | |
IE790996L (en) | Phenylaminothiophene derivatives | |
JPS55118452A (en) | Production of alpha-cyanopropionic ester derivative | |
JPS5538359A (en) | Preparation of 2-(3-benzoylphenyl)-propionic acid | |
JPS54160335A (en) | Preparation of alkylated hydroxybenzoic ester | |
JPS57142966A (en) | (1-alkyl-2-pyrrolyl)glyoxylic acid amide derivative | |
JPS532449A (en) | Preparation of 2-substituted propionic acid derivatives | |
JPS537640A (en) | Synthesis of diphenylamine derivatives | |
JPS5528953A (en) | Racemization of optically active alpha-substituted arylacetic acid | |
JPS54128567A (en) | 1-substituted-4-acyl-2-pyrrolecarboxylic acid derivative | |
JPS53108933A (en) | Production of amidinoformic acid derivative | |
JPS5564592A (en) | Thiazolo 3, 2-a pyrimidine derivative, its preparation, and drug comprising it | |
JPS5750952A (en) | Benzoic acid derivative | |
JPS5716840A (en) | Phneylacetic acid derivative | |
JPS5533433A (en) | Production of 6-nucleoside derivative | |
JPS52131557A (en) | Synthesis of epoxycyclo pentanone derivatives | |
JPS5572139A (en) | Preparation of 4-allyloxy-3,5-disubstituted-phenylacetic acid | |
JPS56127378A (en) | 2-alkoxyindolizine derivative and its preparation | |
JPS54148758A (en) | Alpha-thio-alpha-(2-fluoro-4-biphenylyl)carboxylic acid derivative | |
JPS5587770A (en) | Preparation of 2-(p-isobutylphenyl)propionic acid 2-pyridinemethyl ester | |
JPS55120591A (en) | Phosphinoethylmalonic acid derivative, and preparation thereof | |
JPS53132557A (en) | Novel pyrrole-acetic acid ester derivative | |
JPS5585568A (en) | Quinolinone-imine derivative and its preparation | |
JPS5527163A (en) | Tetrahydroxanthene-2-carboxylic derivative |