JPS55118452A - Production of alpha-cyanopropionic ester derivative - Google Patents

Production of alpha-cyanopropionic ester derivative

Info

Publication number
JPS55118452A
JPS55118452A JP2718779A JP2718779A JPS55118452A JP S55118452 A JPS55118452 A JP S55118452A JP 2718779 A JP2718779 A JP 2718779A JP 2718779 A JP2718779 A JP 2718779A JP S55118452 A JPS55118452 A JP S55118452A
Authority
JP
Japan
Prior art keywords
ester derivative
cyanopropionic
formula
alpha
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2718779A
Other languages
Japanese (ja)
Other versions
JPS629106B2 (en
Inventor
Kanji Noda
Akira Nakagawa
Toshiharu Motomura
Satoru Miyata
Yoichi Nakajima
Hiroyuki Ide
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hisamitsu Pharmaceutical Co Inc
Original Assignee
Hisamitsu Pharmaceutical Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hisamitsu Pharmaceutical Co Inc filed Critical Hisamitsu Pharmaceutical Co Inc
Priority to JP2718779A priority Critical patent/JPS55118452A/en
Publication of JPS55118452A publication Critical patent/JPS55118452A/en
Publication of JPS629106B2 publication Critical patent/JPS629106B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: N,N-Dimethylformamide amidedimethylacetal is used as a C-methylation reagent for a cyanoacetic ester derivative to produce safely title compound useful as synthetic intermediate of anti-inflammatory, analgesic, antipyretic or others.
CONSTITUTION: A cyanoacetic ester derivative of formula I (R1 is 4-isobutylphenyl, 3-benzoylphenyl, 6-methoxy-2-naphthyl; R2 is 1W3C lower alkyl) is made to react with N,N-dimethylformamide amidedimethylacetal of formula II in an amount of 1W2 times molar quantity of the cyanoacetic ester to produce α-cyanopropionic ester derivative of formula III. The reaction is effected in an inert organic solvent at 50W100°C for 1W5hr.
COPYRIGHT: (C)1980,JPO&Japio
JP2718779A 1979-03-06 1979-03-06 Production of alpha-cyanopropionic ester derivative Granted JPS55118452A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2718779A JPS55118452A (en) 1979-03-06 1979-03-06 Production of alpha-cyanopropionic ester derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2718779A JPS55118452A (en) 1979-03-06 1979-03-06 Production of alpha-cyanopropionic ester derivative

Publications (2)

Publication Number Publication Date
JPS55118452A true JPS55118452A (en) 1980-09-11
JPS629106B2 JPS629106B2 (en) 1987-02-26

Family

ID=12214065

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2718779A Granted JPS55118452A (en) 1979-03-06 1979-03-06 Production of alpha-cyanopropionic ester derivative

Country Status (1)

Country Link
JP (1) JPS55118452A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62190097A (en) * 1985-12-20 1987-08-20 ウイスコンシン・アルムナイ・リサ−チ・フアウンデイシヨン Production of (s)-alpha-methylaryl acetate

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62190097A (en) * 1985-12-20 1987-08-20 ウイスコンシン・アルムナイ・リサ−チ・フアウンデイシヨン Production of (s)-alpha-methylaryl acetate
JP2509200B2 (en) * 1985-12-20 1996-06-19 ウイスコンシン・アルムナイ・リサ−チ・フアウンデイシヨン Method for producing (S) -α-methylarylacetic acid

Also Published As

Publication number Publication date
JPS629106B2 (en) 1987-02-26

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