JPS5528953A - Racemization of optically active alpha-substituted arylacetic acid - Google Patents

Racemization of optically active alpha-substituted arylacetic acid

Info

Publication number
JPS5528953A
JPS5528953A JP10232678A JP10232678A JPS5528953A JP S5528953 A JPS5528953 A JP S5528953A JP 10232678 A JP10232678 A JP 10232678A JP 10232678 A JP10232678 A JP 10232678A JP S5528953 A JPS5528953 A JP S5528953A
Authority
JP
Japan
Prior art keywords
optically active
base
racemization
arylacetic acid
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10232678A
Other languages
Japanese (ja)
Other versions
JPS581097B2 (en
Inventor
Katsura Kogure
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nisshin Seifun Group Inc
Original Assignee
Nisshin Seifun Group Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nisshin Seifun Group Inc filed Critical Nisshin Seifun Group Inc
Priority to JP10232678A priority Critical patent/JPS581097B2/en
Publication of JPS5528953A publication Critical patent/JPS5528953A/en
Publication of JPS581097B2 publication Critical patent/JPS581097B2/en
Expired legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To racemize an optically active α-substituted arylacetic acid useful as an antiphlogistic analgesic agent, economically and in high effeciency, by heating the compound with an easily available, low-cost base.
CONSTITUTION: d-or l-2-(6-methoxy-2-naphthyl)-propionic acid or their mixture is racemized by heating at ≥100°C, pref. 110W150°C, in the presence of a base of formula MOR (M is Na, K; R is H, lower alkyl), in a reaction medium having a boiling point of ≥100°C, e.g. DMF, etc. The molar ratio of the optically active compound to the base is 1 to 2.0W2.5. The optically active starting compound can be prepared from 2-methoxynaphthalene according to the reaction formulas.
COPYRIGHT: (C)1980,JPO&Japio
JP10232678A 1978-08-24 1978-08-24 Racemization method for optically active α-substituted aryl acetic acid Expired JPS581097B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10232678A JPS581097B2 (en) 1978-08-24 1978-08-24 Racemization method for optically active α-substituted aryl acetic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10232678A JPS581097B2 (en) 1978-08-24 1978-08-24 Racemization method for optically active α-substituted aryl acetic acid

Publications (2)

Publication Number Publication Date
JPS5528953A true JPS5528953A (en) 1980-02-29
JPS581097B2 JPS581097B2 (en) 1983-01-10

Family

ID=14324415

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10232678A Expired JPS581097B2 (en) 1978-08-24 1978-08-24 Racemization method for optically active α-substituted aryl acetic acid

Country Status (1)

Country Link
JP (1) JPS581097B2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5959647A (en) * 1982-09-28 1984-04-05 Sumitomo Chem Co Ltd Racemization of optically active 2,2-dimethylcyclo- propane-1-carboxylic acid ester
JPS642797U (en) * 1987-06-25 1989-01-10
WO2010001103A1 (en) * 2008-06-30 2010-01-07 Aesica Pharmaceuticals Limited Process for the manufacture of racemic 2-aryl-propionic acid

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5959647A (en) * 1982-09-28 1984-04-05 Sumitomo Chem Co Ltd Racemization of optically active 2,2-dimethylcyclo- propane-1-carboxylic acid ester
JPS617413B2 (en) * 1982-09-28 1986-03-06 Sumitomo Chemical Co
JPS642797U (en) * 1987-06-25 1989-01-10
JPH0516140Y2 (en) * 1987-06-25 1993-04-27
WO2010001103A1 (en) * 2008-06-30 2010-01-07 Aesica Pharmaceuticals Limited Process for the manufacture of racemic 2-aryl-propionic acid
GB2477218A (en) * 2008-06-30 2011-07-27 Aesica Pharmaceuticals Ltd Process for the manufacture of racemic 2-aryl-propionic acid

Also Published As

Publication number Publication date
JPS581097B2 (en) 1983-01-10

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