JPS5528953A - Racemization of optically active alpha-substituted arylacetic acid - Google Patents
Racemization of optically active alpha-substituted arylacetic acidInfo
- Publication number
- JPS5528953A JPS5528953A JP10232678A JP10232678A JPS5528953A JP S5528953 A JPS5528953 A JP S5528953A JP 10232678 A JP10232678 A JP 10232678A JP 10232678 A JP10232678 A JP 10232678A JP S5528953 A JPS5528953 A JP S5528953A
- Authority
- JP
- Japan
- Prior art keywords
- optically active
- base
- racemization
- arylacetic acid
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To racemize an optically active α-substituted arylacetic acid useful as an antiphlogistic analgesic agent, economically and in high effeciency, by heating the compound with an easily available, low-cost base.
CONSTITUTION: d-or l-2-(6-methoxy-2-naphthyl)-propionic acid or their mixture is racemized by heating at ≥100°C, pref. 110W150°C, in the presence of a base of formula MOR (M is Na, K; R is H, lower alkyl), in a reaction medium having a boiling point of ≥100°C, e.g. DMF, etc. The molar ratio of the optically active compound to the base is 1 to 2.0W2.5. The optically active starting compound can be prepared from 2-methoxynaphthalene according to the reaction formulas.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10232678A JPS581097B2 (en) | 1978-08-24 | 1978-08-24 | Racemization method for optically active α-substituted aryl acetic acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10232678A JPS581097B2 (en) | 1978-08-24 | 1978-08-24 | Racemization method for optically active α-substituted aryl acetic acid |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5528953A true JPS5528953A (en) | 1980-02-29 |
JPS581097B2 JPS581097B2 (en) | 1983-01-10 |
Family
ID=14324415
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10232678A Expired JPS581097B2 (en) | 1978-08-24 | 1978-08-24 | Racemization method for optically active α-substituted aryl acetic acid |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS581097B2 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5959647A (en) * | 1982-09-28 | 1984-04-05 | Sumitomo Chem Co Ltd | Racemization of optically active 2,2-dimethylcyclo- propane-1-carboxylic acid ester |
JPS642797U (en) * | 1987-06-25 | 1989-01-10 | ||
WO2010001103A1 (en) * | 2008-06-30 | 2010-01-07 | Aesica Pharmaceuticals Limited | Process for the manufacture of racemic 2-aryl-propionic acid |
-
1978
- 1978-08-24 JP JP10232678A patent/JPS581097B2/en not_active Expired
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5959647A (en) * | 1982-09-28 | 1984-04-05 | Sumitomo Chem Co Ltd | Racemization of optically active 2,2-dimethylcyclo- propane-1-carboxylic acid ester |
JPS617413B2 (en) * | 1982-09-28 | 1986-03-06 | Sumitomo Chemical Co | |
JPS642797U (en) * | 1987-06-25 | 1989-01-10 | ||
JPH0516140Y2 (en) * | 1987-06-25 | 1993-04-27 | ||
WO2010001103A1 (en) * | 2008-06-30 | 2010-01-07 | Aesica Pharmaceuticals Limited | Process for the manufacture of racemic 2-aryl-propionic acid |
GB2477218A (en) * | 2008-06-30 | 2011-07-27 | Aesica Pharmaceuticals Ltd | Process for the manufacture of racemic 2-aryl-propionic acid |
Also Published As
Publication number | Publication date |
---|---|
JPS581097B2 (en) | 1983-01-10 |
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