JPS5555135A - Preparation of d-2-(6-methoxy-2-naphthyl)-propionic acid - Google Patents
Preparation of d-2-(6-methoxy-2-naphthyl)-propionic acidInfo
- Publication number
- JPS5555135A JPS5555135A JP12740278A JP12740278A JPS5555135A JP S5555135 A JPS5555135 A JP S5555135A JP 12740278 A JP12740278 A JP 12740278A JP 12740278 A JP12740278 A JP 12740278A JP S5555135 A JPS5555135 A JP S5555135A
- Authority
- JP
- Japan
- Prior art keywords
- naphthyl
- methoxy
- propionic acid
- acid
- isomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To prepare the d-isomer of 2-(6-methoxy-2-naphthyl)propionic acid, useful as medicine, in high optical purity in an industrial scale, easily and economicaly by optical resolution of d,l-2-(6-methoxy-2-naphthyl)propionic acid with L-(-)-α-phenylethylamine.
CONSTITUTION: d-2-(6-Methoxy-2-naphthyl)propionic acid expressed by the formula is prepared by optical resolution of d,l-2-(6-methoxy-2-naphthyl)propionic acid with L-(-)-α-phenylethylamine. The resolution is carried out as follows. The acid and the amine (0.5W1.0mol on the basis of 1mol of the acid) are dissolved in a solvent. Preferably the solvent is the one which completely dissolves both compounds but poorly dissolves the formed salt, and a preferable example is the mixed solvent of methanol and ethyl acetate. The amine salt of the acid rich in the d-isomer slowly precipitates when the reaction solution is left to stand at room temperatures for 0.5W48hr. The product is further treated with the hot methanol- ethyl acetate mixutre to increase the ratio of the d-isomer, and the salt is decomposed to give the desired product.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12740278A JPS5555135A (en) | 1978-10-18 | 1978-10-18 | Preparation of d-2-(6-methoxy-2-naphthyl)-propionic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12740278A JPS5555135A (en) | 1978-10-18 | 1978-10-18 | Preparation of d-2-(6-methoxy-2-naphthyl)-propionic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5555135A true JPS5555135A (en) | 1980-04-22 |
Family
ID=14959094
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP12740278A Pending JPS5555135A (en) | 1978-10-18 | 1978-10-18 | Preparation of d-2-(6-methoxy-2-naphthyl)-propionic acid |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5555135A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58933A (en) * | 1981-05-18 | 1983-01-06 | ブラスキム・ソチエタ・ペル・アチオニ | Manufacture of d 2-(6'-methoxy-2'-naphthyl)- propionic acid |
| JPH0395138A (en) * | 1989-09-07 | 1991-04-19 | Nissan Chem Ind Ltd | Optical resolution of 3-methylheptanoic acid |
| JPH0682530U (en) * | 1993-11-08 | 1994-11-25 | 呉羽化学工業株式会社 | Pyroelectric device |
-
1978
- 1978-10-18 JP JP12740278A patent/JPS5555135A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58933A (en) * | 1981-05-18 | 1983-01-06 | ブラスキム・ソチエタ・ペル・アチオニ | Manufacture of d 2-(6'-methoxy-2'-naphthyl)- propionic acid |
| JPH0521903B2 (en) * | 1981-05-18 | 1993-03-25 | Burasukimu Spa | |
| JPH0395138A (en) * | 1989-09-07 | 1991-04-19 | Nissan Chem Ind Ltd | Optical resolution of 3-methylheptanoic acid |
| JPH0682530U (en) * | 1993-11-08 | 1994-11-25 | 呉羽化学工業株式会社 | Pyroelectric device |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPS5278848A (en) | Preparation of novel propionic acid ester derivatives | |
| JPS5555135A (en) | Preparation of d-2-(6-methoxy-2-naphthyl)-propionic acid | |
| JPS57146786A (en) | Optically active borane compound and preparation of optically active compound using the same | |
| JPS577438A (en) | Production of acid chloride | |
| JPS5446708A (en) | Preparation of 2, 2, 4-trimethyl-1, 3-pentane-diol diisobutylate | |
| JPS537640A (en) | Synthesis of diphenylamine derivatives | |
| JPS5555136A (en) | Recemization of d- and l-2-(6-methoxy-2-naphthyl)propionic acid mixture | |
| JPS5490158A (en) | Novel benzoylphenoxyacetic acid derivatives | |
| JPS5576881A (en) | Preparation of high-purity coproporphyrin 3 alkali salt | |
| JPS54128584A (en) | Novel 3,4-dihydrocarbostyril derivative | |
| JPS5699480A (en) | Preparation of pyridopyrimidine derivative | |
| JPS5538347A (en) | Preparation of indazoleacetic acids | |
| JPS5651436A (en) | Preparation of p-chlorocarbonylbenzoic acid methyl ester | |
| JPS5735556A (en) | Preparation of guanidinomethylcyclohexanecarboxylic acid ester | |
| JPS57209256A (en) | Novel salt of aminobutyric acid derivative | |
| JPS5738773A (en) | Pyrazoline compound and its preparation | |
| JPS559028A (en) | Novel 3'-(alpha-hydroxybenzyl)-propiophenone and its preparation | |
| JPS54128523A (en) | 3-guanidinoamino propionic acid and its preparation | |
| JPS5645467A (en) | Pantolactone derivative and its preparation | |
| JPS55162786A (en) | Glyoxylic acid derivative and its preparation | |
| JPS5673064A (en) | Isoquinoline derivative | |
| JPS54122231A (en) | Preparation of benzyltributylammonium chloride | |
| JPS57185284A (en) | 7-deazapurine derivative and its preparation | |
| JPS5466640A (en) | Novel acrylophenone derivative and its preparation | |
| JPS5350231A (en) | Preparation of quinoline |