JPS5466640A - Novel acrylophenone derivative and its preparation - Google Patents

Novel acrylophenone derivative and its preparation

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Publication number
JPS5466640A
JPS5466640A JP12969277A JP12969277A JPS5466640A JP S5466640 A JPS5466640 A JP S5466640A JP 12969277 A JP12969277 A JP 12969277A JP 12969277 A JP12969277 A JP 12969277A JP S5466640 A JPS5466640 A JP S5466640A
Authority
JP
Japan
Prior art keywords
formula
acrylophenone
novel
preparation
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP12969277A
Other languages
Japanese (ja)
Inventor
Masahiro Murakami
Takanori Sone
Kiyohide Sako
Mikio Wakabayashi
Ryoji Kodaira
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Chemical Industry Co Ltd
Original Assignee
Asahi Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Chemical Industry Co Ltd filed Critical Asahi Chemical Industry Co Ltd
Priority to JP12969277A priority Critical patent/JPS5466640A/en
Publication of JPS5466640A publication Critical patent/JPS5466640A/en
Pending legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:An acrylophenone derivative of formula I: (R is lower alkyl group).
EXAMPLE: 4'-Ethyl-2-methyl-acrylophenone.
USE: Intermediate forsynthesis of pharmaceuticals. For example, antispasmodics 4'-alkyl-2-methyl-3-piperidino-propiophenone can be obtained by reaction with pipenidine.
PROCESS: A methacrylic acid halide of formula II: ( X is halogen) is condensed with an alkylbenzene of formula III in the presence of a levis acid, e.g. aluminum chlorid, antimory pentachloride, etc. at a low temperature of -30W15°C by the Friedel-crofts reaction to give the objective compound of formula I.
COPYRIGHT: (C)1979,JPO&Japio
JP12969277A 1977-10-31 1977-10-31 Novel acrylophenone derivative and its preparation Pending JPS5466640A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12969277A JPS5466640A (en) 1977-10-31 1977-10-31 Novel acrylophenone derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12969277A JPS5466640A (en) 1977-10-31 1977-10-31 Novel acrylophenone derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS5466640A true JPS5466640A (en) 1979-05-29

Family

ID=15015822

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12969277A Pending JPS5466640A (en) 1977-10-31 1977-10-31 Novel acrylophenone derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5466640A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010195768A (en) * 2009-01-27 2010-09-09 Japan Science & Technology Agency Protein crosslinking inhibitor and use thereof
WO2011055561A1 (en) * 2009-11-06 2011-05-12 独立行政法人科学技術振興機構 Protein crosslinking inhibitor and use thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010195768A (en) * 2009-01-27 2010-09-09 Japan Science & Technology Agency Protein crosslinking inhibitor and use thereof
US8937091B2 (en) 2009-01-27 2015-01-20 Japan Science And Technology Agency Inhibitor of protein crosslinking and use of the same
WO2011055561A1 (en) * 2009-11-06 2011-05-12 独立行政法人科学技術振興機構 Protein crosslinking inhibitor and use thereof

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