JPS5466640A - Novel acrylophenone derivative and its preparation - Google Patents
Novel acrylophenone derivative and its preparationInfo
- Publication number
- JPS5466640A JPS5466640A JP12969277A JP12969277A JPS5466640A JP S5466640 A JPS5466640 A JP S5466640A JP 12969277 A JP12969277 A JP 12969277A JP 12969277 A JP12969277 A JP 12969277A JP S5466640 A JPS5466640 A JP S5466640A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- acrylophenone
- novel
- preparation
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:An acrylophenone derivative of formula I: (R is lower alkyl group).
EXAMPLE: 4'-Ethyl-2-methyl-acrylophenone.
USE: Intermediate forsynthesis of pharmaceuticals. For example, antispasmodics 4'-alkyl-2-methyl-3-piperidino-propiophenone can be obtained by reaction with pipenidine.
PROCESS: A methacrylic acid halide of formula II: ( X is halogen) is condensed with an alkylbenzene of formula III in the presence of a levis acid, e.g. aluminum chlorid, antimory pentachloride, etc. at a low temperature of -30W15°C by the Friedel-crofts reaction to give the objective compound of formula I.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12969277A JPS5466640A (en) | 1977-10-31 | 1977-10-31 | Novel acrylophenone derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12969277A JPS5466640A (en) | 1977-10-31 | 1977-10-31 | Novel acrylophenone derivative and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5466640A true JPS5466640A (en) | 1979-05-29 |
Family
ID=15015822
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12969277A Pending JPS5466640A (en) | 1977-10-31 | 1977-10-31 | Novel acrylophenone derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5466640A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010195768A (en) * | 2009-01-27 | 2010-09-09 | Japan Science & Technology Agency | Protein crosslinking inhibitor and use thereof |
WO2011055561A1 (en) * | 2009-11-06 | 2011-05-12 | 独立行政法人科学技術振興機構 | Protein crosslinking inhibitor and use thereof |
-
1977
- 1977-10-31 JP JP12969277A patent/JPS5466640A/en active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010195768A (en) * | 2009-01-27 | 2010-09-09 | Japan Science & Technology Agency | Protein crosslinking inhibitor and use thereof |
US8937091B2 (en) | 2009-01-27 | 2015-01-20 | Japan Science And Technology Agency | Inhibitor of protein crosslinking and use of the same |
WO2011055561A1 (en) * | 2009-11-06 | 2011-05-12 | 独立行政法人科学技術振興機構 | Protein crosslinking inhibitor and use thereof |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS54148788A (en) | 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative and its preparation | |
JPS5353642A (en) | Preparation of alpha,alpha-dimethylbenzyl-isocyanate or its nuclear-substituted derivatives | |
JPS5466640A (en) | Novel acrylophenone derivative and its preparation | |
JPS5724392A (en) | Preparation of alkynyl compound | |
JPS5466641A (en) | Novel propiophenone derivative and its preparation | |
JPS537640A (en) | Synthesis of diphenylamine derivatives | |
JPS5579333A (en) | Preparation of beta-chlorostyrene | |
JPS5555135A (en) | Preparation of d-2-(6-methoxy-2-naphthyl)-propionic acid | |
JPS5645467A (en) | Pantolactone derivative and its preparation | |
JPS5481264A (en) | Preparation of 1-methyl-5-aroylpryrrole-2-acetic acid | |
JPS56161348A (en) | Preparation of delta-keto-acid | |
JPS5533450A (en) | Preparation of monohalogenosilane | |
JPS5444627A (en) | Production of acrylic acid derivative | |
JPS5643271A (en) | Production of 4-benzoyl-5-hydroxypyrazole | |
JPS5495533A (en) | Preparation of derivative of anthranylaldehyde | |
JPS5649398A (en) | Preparation of 1-beta-d-arabinofuranosyl-2,2'-cyclothymine | |
JPS5721371A (en) | Quinolinoneiminecarboxylic ester derivative, its preparation and anti-inflammatory and analgesic agent composition containing the same | |
JPS5439042A (en) | Preparation of 2-(4-iso butylphenyl)-propionic acid | |
ES8503005A1 (en) | Penicillin derivatives. | |
JPS5770883A (en) | (2-thienylseleno)acetic acid and its preparation | |
JPS5466642A (en) | Novel propiophenone derivative and its preparation | |
JPS5699448A (en) | Preparation of lower alkoxyaniline | |
JPS55160769A (en) | Hydrazinophthalazine derivative | |
JPS5513253A (en) | Cis-3-aralkyl substituted-8-benzoylthio-6,11-dimethyl-2,6- methano-1,2,3,4,5,6-hexahydro-3-benzazocine or its acid addition salt | |
JPS55104227A (en) | Preparation of 3-pentenoic acid |