JPS5721371A - Quinolinoneiminecarboxylic ester derivative, its preparation and anti-inflammatory and analgesic agent composition containing the same - Google Patents

Quinolinoneiminecarboxylic ester derivative, its preparation and anti-inflammatory and analgesic agent composition containing the same

Info

Publication number
JPS5721371A
JPS5721371A JP9462980A JP9462980A JPS5721371A JP S5721371 A JPS5721371 A JP S5721371A JP 9462980 A JP9462980 A JP 9462980A JP 9462980 A JP9462980 A JP 9462980A JP S5721371 A JPS5721371 A JP S5721371A
Authority
JP
Japan
Prior art keywords
expressed
formula
inflammatory
quinolinoneimine
dichlorophenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP9462980A
Other languages
Japanese (ja)
Inventor
Yoshitaka Wakita
Yukio Fujimori
Takumi Matsumura
Katsuya Tani
Hiroshi Kawahara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daito Koeki KK
Original Assignee
Daito Koeki KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daito Koeki KK filed Critical Daito Koeki KK
Priority to JP9462980A priority Critical patent/JPS5721371A/en
Publication of JPS5721371A publication Critical patent/JPS5721371A/en
Pending legal-status Critical Current

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  • Quinoline Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A 1-(2,6-dichlorophenyl)-2-quinolinoneimine-3-carboxylic ester derviative expressed by formula I (R is substituted phenyl, vinyl or ethynyl) or a salt thereof.
EXAMPLE: p-Chlorobenzyl 1-(2,6-dichlorophenyl)-2-quinolinoneimine-3-carboxylate.
USE: An anti-inflammatory and analgesic agent having a slight side effects or an intermediate for peparing o-(2,6-dichloroanilino)phenylacetic acid having anti- inflammatory action and analgesic action.
PROCESS: 1-(2,6-Dichlorophenyl)-2-quinolinoneimine-3-carboxylic acid expressed by formula II is suspended in an organic solvent and converted into a carboxylic acid salt expressed by formula IV (M is alkali metal) in the presence of an alkali metallic compound under cooling with ice. The resultant salt is then reacted with a halide expressed by formula III (X is halogen) to afford the compound expressed by formula I.
COPYRIGHT: (C)1982,JPO&Japio
JP9462980A 1980-07-11 1980-07-11 Quinolinoneiminecarboxylic ester derivative, its preparation and anti-inflammatory and analgesic agent composition containing the same Pending JPS5721371A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP9462980A JPS5721371A (en) 1980-07-11 1980-07-11 Quinolinoneiminecarboxylic ester derivative, its preparation and anti-inflammatory and analgesic agent composition containing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9462980A JPS5721371A (en) 1980-07-11 1980-07-11 Quinolinoneiminecarboxylic ester derivative, its preparation and anti-inflammatory and analgesic agent composition containing the same

Publications (1)

Publication Number Publication Date
JPS5721371A true JPS5721371A (en) 1982-02-04

Family

ID=14115547

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9462980A Pending JPS5721371A (en) 1980-07-11 1980-07-11 Quinolinoneiminecarboxylic ester derivative, its preparation and anti-inflammatory and analgesic agent composition containing the same

Country Status (1)

Country Link
JP (1) JPS5721371A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA013740B1 (en) * 2004-09-17 2010-06-30 Орто-Макнейл-Янссен Фармасьютикалз, Инк. Novel pyridinone derivatives and their use as positive allosteric modulators of mglur2-receptors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5585568A (en) * 1978-12-25 1980-06-27 Daito Koeki Kk Quinolinone-imine derivative and its preparation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5585568A (en) * 1978-12-25 1980-06-27 Daito Koeki Kk Quinolinone-imine derivative and its preparation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA013740B1 (en) * 2004-09-17 2010-06-30 Орто-Макнейл-Янссен Фармасьютикалз, Инк. Novel pyridinone derivatives and their use as positive allosteric modulators of mglur2-receptors

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