JPS54148757A - (2-fluoro-4-biphenylyl) ketene mercaptal s-oxide - Google Patents
(2-fluoro-4-biphenylyl) ketene mercaptal s-oxideInfo
- Publication number
- JPS54148757A JPS54148757A JP5564378A JP5564378A JPS54148757A JP S54148757 A JPS54148757 A JP S54148757A JP 5564378 A JP5564378 A JP 5564378A JP 5564378 A JP5564378 A JP 5564378A JP S54148757 A JPS54148757 A JP S54148757A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- biphenylyl
- fluoro
- base
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:A compound of formula I: (R1 is H or CH3; R2 is alkyl or aryl group).
EXAMPLE: 1-Methylsulfinyl-1-methylthio-2-(2-fluoro-4-biphenylyl)ethylene.
USE: An intermediated for α-(2-fluoro-4-biphenylyl)propionic acid (Flubiprofen) having antiphlogistic, analgesic, and antipyretic actions.
PROCESS: A compound of formula II is reacted with a compound of formula III in the presence of a base at room temperature W150°C to give the compound of formula I: (R1 is H). A relatively strong base, e.g. NaH, KH, or Triton B is preferably used as the base. A compound of formula IV is reacted with a compound of formula II in the presence of a lithiating agent to give a compound of formula IV, which is acylated to convert Li into COR3, and reacted with a base to form the compound of formula I: (R1 is CH3).
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5564378A JPS6051463B2 (en) | 1978-05-12 | 1978-05-12 | (2-Fluoro-4-biphenylyl)ketene mercaptal S-oxides |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5564378A JPS6051463B2 (en) | 1978-05-12 | 1978-05-12 | (2-Fluoro-4-biphenylyl)ketene mercaptal S-oxides |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS54148757A true JPS54148757A (en) | 1979-11-21 |
JPS6051463B2 JPS6051463B2 (en) | 1985-11-14 |
Family
ID=13004485
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP5564378A Expired JPS6051463B2 (en) | 1978-05-12 | 1978-05-12 | (2-Fluoro-4-biphenylyl)ketene mercaptal S-oxides |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6051463B2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0324472A2 (en) * | 1988-01-14 | 1989-07-19 | Nihon Nohyaku Co., Ltd. | Ketenedithioacetal derivatives and processes for producing the same as well as a composition containing the same |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH051818Y2 (en) * | 1986-12-19 | 1993-01-18 | ||
CN113507840A (en) * | 2019-03-01 | 2021-10-15 | 悠亚布莱德公司 | Method for producing frozen food packaged product, film for food packaging, and frozen food packaged product |
-
1978
- 1978-05-12 JP JP5564378A patent/JPS6051463B2/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0324472A2 (en) * | 1988-01-14 | 1989-07-19 | Nihon Nohyaku Co., Ltd. | Ketenedithioacetal derivatives and processes for producing the same as well as a composition containing the same |
Also Published As
Publication number | Publication date |
---|---|
JPS6051463B2 (en) | 1985-11-14 |
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