JPS54148757A - (2-fluoro-4-biphenylyl) ketene mercaptal s-oxide - Google Patents

(2-fluoro-4-biphenylyl) ketene mercaptal s-oxide

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Publication number
JPS54148757A
JPS54148757A JP5564378A JP5564378A JPS54148757A JP S54148757 A JPS54148757 A JP S54148757A JP 5564378 A JP5564378 A JP 5564378A JP 5564378 A JP5564378 A JP 5564378A JP S54148757 A JPS54148757 A JP S54148757A
Authority
JP
Japan
Prior art keywords
compound
formula
biphenylyl
fluoro
base
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP5564378A
Other languages
Japanese (ja)
Other versions
JPS6051463B2 (en
Inventor
Genichi Dobashi
Katsuyuki Ogura
Mitsuo Yamashita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sagami Chemical Research Institute
Original Assignee
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sagami Chemical Research Institute filed Critical Sagami Chemical Research Institute
Priority to JP5564378A priority Critical patent/JPS6051463B2/en
Publication of JPS54148757A publication Critical patent/JPS54148757A/en
Publication of JPS6051463B2 publication Critical patent/JPS6051463B2/en
Expired legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:A compound of formula I: (R1 is H or CH3; R2 is alkyl or aryl group).
EXAMPLE: 1-Methylsulfinyl-1-methylthio-2-(2-fluoro-4-biphenylyl)ethylene.
USE: An intermediated for α-(2-fluoro-4-biphenylyl)propionic acid (Flubiprofen) having antiphlogistic, analgesic, and antipyretic actions.
PROCESS: A compound of formula II is reacted with a compound of formula III in the presence of a base at room temperature W150°C to give the compound of formula I: (R1 is H). A relatively strong base, e.g. NaH, KH, or Triton B is preferably used as the base. A compound of formula IV is reacted with a compound of formula II in the presence of a lithiating agent to give a compound of formula IV, which is acylated to convert Li into COR3, and reacted with a base to form the compound of formula I: (R1 is CH3).
COPYRIGHT: (C)1979,JPO&Japio
JP5564378A 1978-05-12 1978-05-12 (2-Fluoro-4-biphenylyl)ketene mercaptal S-oxides Expired JPS6051463B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP5564378A JPS6051463B2 (en) 1978-05-12 1978-05-12 (2-Fluoro-4-biphenylyl)ketene mercaptal S-oxides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5564378A JPS6051463B2 (en) 1978-05-12 1978-05-12 (2-Fluoro-4-biphenylyl)ketene mercaptal S-oxides

Publications (2)

Publication Number Publication Date
JPS54148757A true JPS54148757A (en) 1979-11-21
JPS6051463B2 JPS6051463B2 (en) 1985-11-14

Family

ID=13004485

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5564378A Expired JPS6051463B2 (en) 1978-05-12 1978-05-12 (2-Fluoro-4-biphenylyl)ketene mercaptal S-oxides

Country Status (1)

Country Link
JP (1) JPS6051463B2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0324472A2 (en) * 1988-01-14 1989-07-19 Nihon Nohyaku Co., Ltd. Ketenedithioacetal derivatives and processes for producing the same as well as a composition containing the same

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH051818Y2 (en) * 1986-12-19 1993-01-18
CN113507840A (en) * 2019-03-01 2021-10-15 悠亚布莱德公司 Method for producing frozen food packaged product, film for food packaging, and frozen food packaged product

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0324472A2 (en) * 1988-01-14 1989-07-19 Nihon Nohyaku Co., Ltd. Ketenedithioacetal derivatives and processes for producing the same as well as a composition containing the same

Also Published As

Publication number Publication date
JPS6051463B2 (en) 1985-11-14

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