JPS5745151A - Alpha-sulfonyl 2-fluoro-4-biphenylyl propionic acid derivative - Google Patents
Alpha-sulfonyl 2-fluoro-4-biphenylyl propionic acid derivativeInfo
- Publication number
- JPS5745151A JPS5745151A JP11220281A JP11220281A JPS5745151A JP S5745151 A JPS5745151 A JP S5745151A JP 11220281 A JP11220281 A JP 11220281A JP 11220281 A JP11220281 A JP 11220281A JP S5745151 A JPS5745151 A JP S5745151A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- expressed
- fluoro
- biphenylyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:A compound expressed by formula I [R1 is alkyl or (substituted) phenyl; R2 is alkyl]. UXAMPLE:Ethyl α-(2-fluoro-4-biphenylyl)-α-(p-tolylsulfonyl)propionate.
USE: An intermediate for medicines and an intermediate for flubiprofen which is a compound having anti-inflammatory, analgesic and antipyretic actions.
PROCESS: The methyl group of 3-fluoro-4-phenyltoluene expressed by formula II is halogenated and reacted with a compound expressed by the formula R1SO2H to give a sulfone derivative expressed by formula IV. The resultant sulfone derivative expressed by formula IV is then reacted with a dialkyl carbonate in the presence of a base to afford a compound expressed by formula V, which is further reacted with a methylating agent, e.g. a methyl halide or active methyl ester, to give the compound expressed by formula I.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11220281A JPS5745151A (en) | 1981-07-20 | 1981-07-20 | Alpha-sulfonyl 2-fluoro-4-biphenylyl propionic acid derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11220281A JPS5745151A (en) | 1981-07-20 | 1981-07-20 | Alpha-sulfonyl 2-fluoro-4-biphenylyl propionic acid derivative |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8283680A Division JPS579757A (en) | 1980-06-20 | 1980-06-20 | Alpha-sulfonyl 2-fluoro-4-biphenylyl acetic acid derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5745151A true JPS5745151A (en) | 1982-03-13 |
JPS6217993B2 JPS6217993B2 (en) | 1987-04-21 |
Family
ID=14580808
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP11220281A Granted JPS5745151A (en) | 1981-07-20 | 1981-07-20 | Alpha-sulfonyl 2-fluoro-4-biphenylyl propionic acid derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5745151A (en) |
-
1981
- 1981-07-20 JP JP11220281A patent/JPS5745151A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS6217993B2 (en) | 1987-04-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE3369972D1 (en) | Ethoxycarbonyloxy ethyl esters of non-steroidal anti-inflammatory carboxylic acids, their preparation and use | |
JPS5278848A (en) | Preparation of novel propionic acid ester derivatives | |
JPS5745151A (en) | Alpha-sulfonyl 2-fluoro-4-biphenylyl propionic acid derivative | |
JPS574987A (en) | Pyridoindolecarboxylic acid derivative and its preparation | |
JPS54148757A (en) | (2-fluoro-4-biphenylyl) ketene mercaptal s-oxide | |
JPS579757A (en) | Alpha-sulfonyl 2-fluoro-4-biphenylyl acetic acid derivative | |
JPS5764655A (en) | Novel benzoylaminophenylcarboxylic acid derivative, its preparation, and drug composition comprising it | |
JPS52139034A (en) | Imide compounds and herbicidal composition containing the same | |
JPS56125338A (en) | Phenylacetic acid derivative | |
JPS5589245A (en) | 9,10-dihydroanthracene-2-alkanoic acid derivative | |
JPS54148758A (en) | Alpha-thio-alpha-(2-fluoro-4-biphenylyl)carboxylic acid derivative | |
JPS5481260A (en) | 2-4-(3-methyl-2-thienyl)phenyl propionic acid, its nontoxic salt and antiphlogistics, analgesics, and antirheumatics containing them | |
JPS54130599A (en) | Furoindole derivative | |
JPS5461169A (en) | Alpha-thio-alpha-(2-thienyl)caboxylic acid derivatives | |
JPS57206640A (en) | Preparation of novel propionic ester derivative | |
JPS55143973A (en) | Phenylacetic acid derivative | |
JPS554334A (en) | Pyranopyrazole derivative | |
JPS5479265A (en) | 2-(2,2-dihalovinyl)thiophene and its preparation | |
JPS5735543A (en) | Novel phenylacetic acid derivative | |
IE800978L (en) | Esters of 2-(6-methoxy-2-naphthyl)-1-propanol | |
JPS5373566A (en) | 7,8,9,10,-tetrahydrophenanthridone-3-acetic acids | |
JPS57203035A (en) | Carboxylic acid ester | |
JPS5283436A (en) | Preparation of intermediates for synthesis of prostaglandin | |
JPS53124233A (en) | Alpha-(p-isobutylphenyl)-alpha-alkylthioacetic acids and their esters | |
JPS57212137A (en) | Preparation of phenyl aliphtic acid derivative |