JPS5745151A - Alpha-sulfonyl 2-fluoro-4-biphenylyl propionic acid derivative - Google Patents

Alpha-sulfonyl 2-fluoro-4-biphenylyl propionic acid derivative

Info

Publication number
JPS5745151A
JPS5745151A JP11220281A JP11220281A JPS5745151A JP S5745151 A JPS5745151 A JP S5745151A JP 11220281 A JP11220281 A JP 11220281A JP 11220281 A JP11220281 A JP 11220281A JP S5745151 A JPS5745151 A JP S5745151A
Authority
JP
Japan
Prior art keywords
formula
expressed
fluoro
biphenylyl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP11220281A
Other languages
Japanese (ja)
Other versions
JPS6217993B2 (en
Inventor
Genichi Dobashi
Mitsuo Yamashita
Katsuyuki Ogura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sagami Chemical Research Institute
Original Assignee
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sagami Chemical Research Institute filed Critical Sagami Chemical Research Institute
Priority to JP11220281A priority Critical patent/JPS5745151A/en
Publication of JPS5745151A publication Critical patent/JPS5745151A/en
Publication of JPS6217993B2 publication Critical patent/JPS6217993B2/ja
Granted legal-status Critical Current

Links

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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:A compound expressed by formula I [R1 is alkyl or (substituted) phenyl; R2 is alkyl]. UXAMPLE:Ethyl α-(2-fluoro-4-biphenylyl)-α-(p-tolylsulfonyl)propionate.
USE: An intermediate for medicines and an intermediate for flubiprofen which is a compound having anti-inflammatory, analgesic and antipyretic actions.
PROCESS: The methyl group of 3-fluoro-4-phenyltoluene expressed by formula II is halogenated and reacted with a compound expressed by the formula R1SO2H to give a sulfone derivative expressed by formula IV. The resultant sulfone derivative expressed by formula IV is then reacted with a dialkyl carbonate in the presence of a base to afford a compound expressed by formula V, which is further reacted with a methylating agent, e.g. a methyl halide or active methyl ester, to give the compound expressed by formula I.
COPYRIGHT: (C)1982,JPO&Japio
JP11220281A 1981-07-20 1981-07-20 Alpha-sulfonyl 2-fluoro-4-biphenylyl propionic acid derivative Granted JPS5745151A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP11220281A JPS5745151A (en) 1981-07-20 1981-07-20 Alpha-sulfonyl 2-fluoro-4-biphenylyl propionic acid derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11220281A JPS5745151A (en) 1981-07-20 1981-07-20 Alpha-sulfonyl 2-fluoro-4-biphenylyl propionic acid derivative

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP8283680A Division JPS579757A (en) 1980-06-20 1980-06-20 Alpha-sulfonyl 2-fluoro-4-biphenylyl acetic acid derivative

Publications (2)

Publication Number Publication Date
JPS5745151A true JPS5745151A (en) 1982-03-13
JPS6217993B2 JPS6217993B2 (en) 1987-04-21

Family

ID=14580808

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11220281A Granted JPS5745151A (en) 1981-07-20 1981-07-20 Alpha-sulfonyl 2-fluoro-4-biphenylyl propionic acid derivative

Country Status (1)

Country Link
JP (1) JPS5745151A (en)

Also Published As

Publication number Publication date
JPS6217993B2 (en) 1987-04-21

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