JPS54109942A - Preparation of phenylacetic acid derivative - Google Patents

Preparation of phenylacetic acid derivative

Info

Publication number
JPS54109942A
JPS54109942A JP1407278A JP1407278A JPS54109942A JP S54109942 A JPS54109942 A JP S54109942A JP 1407278 A JP1407278 A JP 1407278A JP 1407278 A JP1407278 A JP 1407278A JP S54109942 A JPS54109942 A JP S54109942A
Authority
JP
Japan
Prior art keywords
dichloroanilino
reacted
phenylacetic acid
preparation
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP1407278A
Other languages
Japanese (ja)
Inventor
Shoichiro Miyahara
Yoshitsugu Yamada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsui Toatsu Chemicals Inc
Original Assignee
Mitsui Toatsu Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Toatsu Chemicals Inc filed Critical Mitsui Toatsu Chemicals Inc
Priority to JP1407278A priority Critical patent/JPS54109942A/en
Publication of JPS54109942A publication Critical patent/JPS54109942A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To obtain the title compound useful as antiphlogistics and analgesics in high yield readily, by converting 2-(2,6-dichloroanilino) halogenated benzyl to the corresponding Grignard compound, which is reacted with carbon dioxide and hydrolyzed.
CONSTITUTION: 2-(2,6-dichloroanilino) halogenated benzyl, preferably chloro-or bromobenzyl, or formula I: (X is Cl, Br, or I) is reacted with Mg in a dry solvent, e.g. diethyl ether, to give a Grignard compound of formula III, which is reacted with CO2 and hydrolyzed to form 2-(2,6-dichloroanilino)phenylacetic acid of formula II, commonly known as Diclofenuc.
COPYRIGHT: (C)1979,JPO&Japio
JP1407278A 1978-02-13 1978-02-13 Preparation of phenylacetic acid derivative Pending JPS54109942A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP1407278A JPS54109942A (en) 1978-02-13 1978-02-13 Preparation of phenylacetic acid derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1407278A JPS54109942A (en) 1978-02-13 1978-02-13 Preparation of phenylacetic acid derivative

Publications (1)

Publication Number Publication Date
JPS54109942A true JPS54109942A (en) 1979-08-29

Family

ID=11850891

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1407278A Pending JPS54109942A (en) 1978-02-13 1978-02-13 Preparation of phenylacetic acid derivative

Country Status (1)

Country Link
JP (1) JPS54109942A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56127338A (en) * 1980-03-10 1981-10-06 Morishita Seiyaku Kk Basic amino acid salt of diclofenac and suppository containing the same

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56127338A (en) * 1980-03-10 1981-10-06 Morishita Seiyaku Kk Basic amino acid salt of diclofenac and suppository containing the same
JPH0223527B2 (en) * 1980-03-10 1990-05-24 Morishita Pharma

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