JPS54109942A - Preparation of phenylacetic acid derivative - Google Patents
Preparation of phenylacetic acid derivativeInfo
- Publication number
- JPS54109942A JPS54109942A JP1407278A JP1407278A JPS54109942A JP S54109942 A JPS54109942 A JP S54109942A JP 1407278 A JP1407278 A JP 1407278A JP 1407278 A JP1407278 A JP 1407278A JP S54109942 A JPS54109942 A JP S54109942A
- Authority
- JP
- Japan
- Prior art keywords
- dichloroanilino
- reacted
- phenylacetic acid
- preparation
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To obtain the title compound useful as antiphlogistics and analgesics in high yield readily, by converting 2-(2,6-dichloroanilino) halogenated benzyl to the corresponding Grignard compound, which is reacted with carbon dioxide and hydrolyzed.
CONSTITUTION: 2-(2,6-dichloroanilino) halogenated benzyl, preferably chloro-or bromobenzyl, or formula I: (X is Cl, Br, or I) is reacted with Mg in a dry solvent, e.g. diethyl ether, to give a Grignard compound of formula III, which is reacted with CO2 and hydrolyzed to form 2-(2,6-dichloroanilino)phenylacetic acid of formula II, commonly known as Diclofenuc.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1407278A JPS54109942A (en) | 1978-02-13 | 1978-02-13 | Preparation of phenylacetic acid derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1407278A JPS54109942A (en) | 1978-02-13 | 1978-02-13 | Preparation of phenylacetic acid derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS54109942A true JPS54109942A (en) | 1979-08-29 |
Family
ID=11850891
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1407278A Pending JPS54109942A (en) | 1978-02-13 | 1978-02-13 | Preparation of phenylacetic acid derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS54109942A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS56127338A (en) * | 1980-03-10 | 1981-10-06 | Morishita Seiyaku Kk | Basic amino acid salt of diclofenac and suppository containing the same |
-
1978
- 1978-02-13 JP JP1407278A patent/JPS54109942A/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS56127338A (en) * | 1980-03-10 | 1981-10-06 | Morishita Seiyaku Kk | Basic amino acid salt of diclofenac and suppository containing the same |
JPH0223527B2 (en) * | 1980-03-10 | 1990-05-24 | Morishita Pharma |
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