JPS554319A - Preparation of indan-1-carboxylic acid - Google Patents
Preparation of indan-1-carboxylic acidInfo
- Publication number
- JPS554319A JPS554319A JP7629178A JP7629178A JPS554319A JP S554319 A JPS554319 A JP S554319A JP 7629178 A JP7629178 A JP 7629178A JP 7629178 A JP7629178 A JP 7629178A JP S554319 A JPS554319 A JP S554319A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- carboxylic acid
- indan
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To obtain the title compound useful as analgesics, antiphlogistics, and antipyretics, in a simple process in high yield, by carboxylating a novel indene derivative with CO in the presence of a hydroxy compound, including carboxylation.
CONSTITUTION: A novel indene derivative of formula I: (R is cycloalkyl group; X is halogen), e.g. 5-chloro-6-cyclohexylindene, is reacted with CO in the presence of a hydroxy compound, e.g. water, of the formula R'OH (R' is H, alkyl, or aralkyl group) to give the objective compound of formula II, e.g. 5-cyclohexyl-6-chloroindan-1-carboxylic acid. The indene derivative of formula I is reacted with a mixture of CO and H2 to form indene-1-carboaldehyde of formula III, which is then oxidized to afford the compound of formula II wherein R' is H.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7629178A JPS554319A (en) | 1978-06-23 | 1978-06-23 | Preparation of indan-1-carboxylic acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7629178A JPS554319A (en) | 1978-06-23 | 1978-06-23 | Preparation of indan-1-carboxylic acid |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS554319A true JPS554319A (en) | 1980-01-12 |
Family
ID=13601224
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP7629178A Pending JPS554319A (en) | 1978-06-23 | 1978-06-23 | Preparation of indan-1-carboxylic acid |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS554319A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4613702A (en) * | 1984-05-15 | 1986-09-23 | Rhone-Poulenc Specialites Chimiques | Aldehyde production by hydrocarbonylation of organic halides |
-
1978
- 1978-06-23 JP JP7629178A patent/JPS554319A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4613702A (en) * | 1984-05-15 | 1986-09-23 | Rhone-Poulenc Specialites Chimiques | Aldehyde production by hydrocarbonylation of organic halides |
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