JPS5522613A - Preparation of 2-hydroxy-3-butenoic acid derivative - Google Patents

Preparation of 2-hydroxy-3-butenoic acid derivative

Info

Publication number
JPS5522613A
JPS5522613A JP9450678A JP9450678A JPS5522613A JP S5522613 A JPS5522613 A JP S5522613A JP 9450678 A JP9450678 A JP 9450678A JP 9450678 A JP9450678 A JP 9450678A JP S5522613 A JPS5522613 A JP S5522613A
Authority
JP
Japan
Prior art keywords
magnesium bromide
mole
acid ester
hydroxy
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP9450678A
Other languages
Japanese (ja)
Other versions
JPS5819662B2 (en
Inventor
Katsura Kogure
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nisshin Seifun Group Inc
Original Assignee
Nisshin Seifun Group Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nisshin Seifun Group Inc filed Critical Nisshin Seifun Group Inc
Priority to JP9450678A priority Critical patent/JPS5819662B2/en
Publication of JPS5522613A publication Critical patent/JPS5522613A/en
Publication of JPS5819662B2 publication Critical patent/JPS5819662B2/en
Expired legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To prepare a 2-hydroxy-3-butenoic acid derivative useful as an intermediate of naproxen useful as an antiphlogistic, in high yield, by treating a glycidic acid ester derivative with magnesium bromide.
CONSTITUTION: 1 Mole of a glycidic acid ester derivative I (R is lower alkyl) is reacted with 0.5W3 moles of magnesium bromide at 20W80°C for 2W4 hy substantially in the absence of water to give the desired compound II. The reaction of about 1.0W1.2 mole of magnesium bromide with 1 mole of the compound I gives the desired compound in an extremely high yield. Preferably, magnesium bromide prepared by reacting metallic magnesium with dibromoethane, etc. in an organic solvent, is used in the suspension state immediately after preparation. The raw material I is prepared, e.g. by reacting the compound III with a chloroacetic acid ester under the condition of Darzens' condensation.
COPYRIGHT: (C)1980,JPO&Japio
JP9450678A 1978-08-04 1978-08-04 Method for producing 2↓-hydroxy↓-3↓-butenoic acid derivative Expired JPS5819662B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP9450678A JPS5819662B2 (en) 1978-08-04 1978-08-04 Method for producing 2↓-hydroxy↓-3↓-butenoic acid derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9450678A JPS5819662B2 (en) 1978-08-04 1978-08-04 Method for producing 2↓-hydroxy↓-3↓-butenoic acid derivative

Publications (2)

Publication Number Publication Date
JPS5522613A true JPS5522613A (en) 1980-02-18
JPS5819662B2 JPS5819662B2 (en) 1983-04-19

Family

ID=14112192

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9450678A Expired JPS5819662B2 (en) 1978-08-04 1978-08-04 Method for producing 2↓-hydroxy↓-3↓-butenoic acid derivative

Country Status (1)

Country Link
JP (1) JPS5819662B2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6399550U (en) * 1986-12-18 1988-06-28

Also Published As

Publication number Publication date
JPS5819662B2 (en) 1983-04-19

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