JPS5522613A - Preparation of 2-hydroxy-3-butenoic acid derivative - Google Patents
Preparation of 2-hydroxy-3-butenoic acid derivativeInfo
- Publication number
- JPS5522613A JPS5522613A JP9450678A JP9450678A JPS5522613A JP S5522613 A JPS5522613 A JP S5522613A JP 9450678 A JP9450678 A JP 9450678A JP 9450678 A JP9450678 A JP 9450678A JP S5522613 A JPS5522613 A JP S5522613A
- Authority
- JP
- Japan
- Prior art keywords
- magnesium bromide
- mole
- acid ester
- hydroxy
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To prepare a 2-hydroxy-3-butenoic acid derivative useful as an intermediate of naproxen useful as an antiphlogistic, in high yield, by treating a glycidic acid ester derivative with magnesium bromide.
CONSTITUTION: 1 Mole of a glycidic acid ester derivative I (R is lower alkyl) is reacted with 0.5W3 moles of magnesium bromide at 20W80°C for 2W4 hy substantially in the absence of water to give the desired compound II. The reaction of about 1.0W1.2 mole of magnesium bromide with 1 mole of the compound I gives the desired compound in an extremely high yield. Preferably, magnesium bromide prepared by reacting metallic magnesium with dibromoethane, etc. in an organic solvent, is used in the suspension state immediately after preparation. The raw material I is prepared, e.g. by reacting the compound III with a chloroacetic acid ester under the condition of Darzens' condensation.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9450678A JPS5819662B2 (en) | 1978-08-04 | 1978-08-04 | Method for producing 2↓-hydroxy↓-3↓-butenoic acid derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9450678A JPS5819662B2 (en) | 1978-08-04 | 1978-08-04 | Method for producing 2↓-hydroxy↓-3↓-butenoic acid derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5522613A true JPS5522613A (en) | 1980-02-18 |
JPS5819662B2 JPS5819662B2 (en) | 1983-04-19 |
Family
ID=14112192
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9450678A Expired JPS5819662B2 (en) | 1978-08-04 | 1978-08-04 | Method for producing 2↓-hydroxy↓-3↓-butenoic acid derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5819662B2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6399550U (en) * | 1986-12-18 | 1988-06-28 |
-
1978
- 1978-08-04 JP JP9450678A patent/JPS5819662B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
JPS5819662B2 (en) | 1983-04-19 |
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