JPS5587748A - Preparation of o-(2,6-dichloroanilino)phenylacetic acid - Google Patents

Preparation of o-(2,6-dichloroanilino)phenylacetic acid

Info

Publication number
JPS5587748A
JPS5587748A JP16269878A JP16269878A JPS5587748A JP S5587748 A JPS5587748 A JP S5587748A JP 16269878 A JP16269878 A JP 16269878A JP 16269878 A JP16269878 A JP 16269878A JP S5587748 A JPS5587748 A JP S5587748A
Authority
JP
Japan
Prior art keywords
dichloroanilino
formula
dialkyl
base
phenylacetic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP16269878A
Other languages
Japanese (ja)
Inventor
Katsuya Tani
Yukio Fujimori
Hiroyuki Kondo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daito Koeki KK
Original Assignee
Daito Koeki KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daito Koeki KK filed Critical Daito Koeki KK
Priority to JP16269878A priority Critical patent/JPS5587748A/en
Publication of JPS5587748A publication Critical patent/JPS5587748A/en
Pending legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To prepare the title compound useful as an antiphlogistic agent, easily, with a few steps, by hydrolyzing an N,N-dialkyl-[o-(2,6-dichloroanilino)phenyl] acetamide derivative in the presence of a base.
CONSTITUTION: o-(2,6-Dichloroanilino)phenylacetic acid of formula II is prepared by hydrolyzing an N,N-dialkyl-[o-(2,6-dichloroanilino)-phenylacetamide derivative of formula I (R1,2 are lower alkyl) in a solvent such as ethanol, in the presence of a base such as KOH, at the refluxing temperature of the solvent. The amount of the base is pref. 10W20mol per 1mol of the acetamide derivative. The compound of formula I can be prepared by reacting an N,N-dialkyl-(o-halogenophenyl)acetamide derivative of formula III (X is Br or I) with 2,6-dichloroaniline of formula IV in the presence of a copper catalyst.
COPYRIGHT: (C)1980,JPO&Japio
JP16269878A 1978-12-26 1978-12-26 Preparation of o-(2,6-dichloroanilino)phenylacetic acid Pending JPS5587748A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP16269878A JPS5587748A (en) 1978-12-26 1978-12-26 Preparation of o-(2,6-dichloroanilino)phenylacetic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP16269878A JPS5587748A (en) 1978-12-26 1978-12-26 Preparation of o-(2,6-dichloroanilino)phenylacetic acid

Publications (1)

Publication Number Publication Date
JPS5587748A true JPS5587748A (en) 1980-07-02

Family

ID=15759592

Family Applications (1)

Application Number Title Priority Date Filing Date
JP16269878A Pending JPS5587748A (en) 1978-12-26 1978-12-26 Preparation of o-(2,6-dichloroanilino)phenylacetic acid

Country Status (1)

Country Link
JP (1) JPS5587748A (en)

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