JPS5788170A - Thiazolidone derivative - Google Patents

Thiazolidone derivative

Info

Publication number
JPS5788170A
JPS5788170A JP16291180A JP16291180A JPS5788170A JP S5788170 A JPS5788170 A JP S5788170A JP 16291180 A JP16291180 A JP 16291180A JP 16291180 A JP16291180 A JP 16291180A JP S5788170 A JPS5788170 A JP S5788170A
Authority
JP
Japan
Prior art keywords
expressed
formula
acid
formulai
refluxed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP16291180A
Other languages
Japanese (ja)
Other versions
JPH0144708B2 (en
Inventor
Kanji Noda
Akira Nakagawa
Toshiharu Motomura
Hiroyuki Ide
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hisamitsu Pharmaceutical Co Inc
Original Assignee
Hisamitsu Pharmaceutical Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hisamitsu Pharmaceutical Co Inc filed Critical Hisamitsu Pharmaceutical Co Inc
Priority to JP16291180A priority Critical patent/JPS5788170A/en
Publication of JPS5788170A publication Critical patent/JPS5788170A/en
Publication of JPH0144708B2 publication Critical patent/JPH0144708B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

NEW MATERIAL:A compound expressed by formulaI(R is H or CH3; R1 and R2 are lower alkyl; A is aryl or pyridyl).
EXAMPLE: 2-Phenyl-3-(p-phenylacetic acid)-4-thiazolidone.
USE: An anti-inflammatory agent, analgesic agent and antirheumatic agent.
PROCESS: An aldehyde expressed by formula II is refluxed with a phenylalkanoic acid or an ester derivative thereof expressed by formula III in a solvent, e.g. methanol or THF, under heating to give an intermediate for a Schiff base expressed by formula IV. Thiolatctic acid or thioglycolic acid expressed by formula V or an ester derivative thereof is then added to the resultant intermediate at room temperature, and the reaction mixture is refluxed in a Dean-Stark trap vigorously for 1W40hr under heating to afford the compound expressed by formulaI.
COPYRIGHT: (C)1982,JPO&Japio
JP16291180A 1980-11-18 1980-11-18 Thiazolidone derivative Granted JPS5788170A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP16291180A JPS5788170A (en) 1980-11-18 1980-11-18 Thiazolidone derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP16291180A JPS5788170A (en) 1980-11-18 1980-11-18 Thiazolidone derivative

Publications (2)

Publication Number Publication Date
JPS5788170A true JPS5788170A (en) 1982-06-01
JPH0144708B2 JPH0144708B2 (en) 1989-09-29

Family

ID=15763564

Family Applications (1)

Application Number Title Priority Date Filing Date
JP16291180A Granted JPS5788170A (en) 1980-11-18 1980-11-18 Thiazolidone derivative

Country Status (1)

Country Link
JP (1) JPS5788170A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4992455A (en) * 1987-05-22 1991-02-12 Sumitomo Pharmaceuticals Company, Limited Thiazolidin-4-one derivatives useful for treating diseases caused by platelet activating factor
US5021435A (en) * 1988-01-22 1991-06-04 Sumitomo Pharmaceuticals Company, Limited Certain pyridyl-thiazolidin-4-one having anti-ulcer activity
US5393741A (en) * 1990-11-30 1995-02-28 Norsk Hydro A.S. Acetal derivatives of aromatic aldehydes
US6506751B1 (en) 1999-11-12 2003-01-14 Millennium Pharmaceuticals, Inc. Thiazolidinone compounds useful as chemokine inhibitors
EP1506180A4 (en) * 2002-05-17 2006-04-05 Cj Corp Thiazolidine-4-one derivative, method for preparing the same, and pharmaceutical composition containing the same
US20170253569A1 (en) * 2016-03-07 2017-09-07 National Health Research Institutes Thiazolidinone compounds and use thereof

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4992455A (en) * 1987-05-22 1991-02-12 Sumitomo Pharmaceuticals Company, Limited Thiazolidin-4-one derivatives useful for treating diseases caused by platelet activating factor
US5021435A (en) * 1988-01-22 1991-06-04 Sumitomo Pharmaceuticals Company, Limited Certain pyridyl-thiazolidin-4-one having anti-ulcer activity
US5393741A (en) * 1990-11-30 1995-02-28 Norsk Hydro A.S. Acetal derivatives of aromatic aldehydes
US6506751B1 (en) 1999-11-12 2003-01-14 Millennium Pharmaceuticals, Inc. Thiazolidinone compounds useful as chemokine inhibitors
EP1506180A4 (en) * 2002-05-17 2006-04-05 Cj Corp Thiazolidine-4-one derivative, method for preparing the same, and pharmaceutical composition containing the same
US20170253569A1 (en) * 2016-03-07 2017-09-07 National Health Research Institutes Thiazolidinone compounds and use thereof
US10544113B2 (en) * 2016-03-07 2020-01-28 National Health Research Institute Thiazolidinone compounds and use thereof

Also Published As

Publication number Publication date
JPH0144708B2 (en) 1989-09-29

Similar Documents

Publication Publication Date Title
JPS5592370A (en) Phenoxypyridine derivative and its preparation
JPS56100784A (en) Indolizine derivative
JPS5788170A (en) Thiazolidone derivative
JPS53135958A (en) Substituted phenylacetic acid derivatives and their preparation
JPS5750952A (en) Benzoic acid derivative
JPS57126427A (en) Preparation of 1-substituted-azulene derivative
JPS5436226A (en) Preparation of derivative of phenyl acetic acid
JPS5716840A (en) Phneylacetic acid derivative
JPS55164682A (en) 1-alkyl-2-oxo-2h-1,8-naphthyridine derivative and its preparation
JPS5547673A (en) Novel pyrone derivative
JPS572257A (en) Preparation of 4-hydroxybenzylnitrile derivative
JPS5750946A (en) Novel anthranilic acid derivative
JPS55153777A (en) Improved method of preparation of 3-methyl-3-(substituted phenyl)-glycidic ester
JPS56127378A (en) 2-alkoxyindolizine derivative and its preparation
JPS55149256A (en) Novel preparation of isoindoline derivative
JPS55118452A (en) Production of alpha-cyanopropionic ester derivative
JPS5466653A (en) Novel p-aminophenylacetic acid derivative, its preparation, and pharmaceurtical composition containing said derivative as effective component
JPS5522634A (en) Novel aminonicotinic acid derivative
JPS568345A (en) Production of propionic acid derivative and its ester
JPS5587748A (en) Preparation of o-(2,6-dichloroanilino)phenylacetic acid
JPS5527142A (en) Novel 1-phthalazone derivative
JPS5538809A (en) Preparation of resin composition
JPS55143925A (en) Preparation of cyclopentenolone
JPS54148758A (en) Alpha-thio-alpha-(2-fluoro-4-biphenylyl)carboxylic acid derivative
JPS52111513A (en) Preparation of 3,3-dimethyl-4-penthnoic acid methyl ester