JPS5788170A - Thiazolidone derivative - Google Patents
Thiazolidone derivativeInfo
- Publication number
- JPS5788170A JPS5788170A JP16291180A JP16291180A JPS5788170A JP S5788170 A JPS5788170 A JP S5788170A JP 16291180 A JP16291180 A JP 16291180A JP 16291180 A JP16291180 A JP 16291180A JP S5788170 A JPS5788170 A JP S5788170A
- Authority
- JP
- Japan
- Prior art keywords
- expressed
- formula
- acid
- formulai
- refluxed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
NEW MATERIAL:A compound expressed by formulaI(R is H or CH3; R1 and R2 are lower alkyl; A is aryl or pyridyl).
EXAMPLE: 2-Phenyl-3-(p-phenylacetic acid)-4-thiazolidone.
USE: An anti-inflammatory agent, analgesic agent and antirheumatic agent.
PROCESS: An aldehyde expressed by formula II is refluxed with a phenylalkanoic acid or an ester derivative thereof expressed by formula III in a solvent, e.g. methanol or THF, under heating to give an intermediate for a Schiff base expressed by formula IV. Thiolatctic acid or thioglycolic acid expressed by formula V or an ester derivative thereof is then added to the resultant intermediate at room temperature, and the reaction mixture is refluxed in a Dean-Stark trap vigorously for 1W40hr under heating to afford the compound expressed by formulaI.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16291180A JPS5788170A (en) | 1980-11-18 | 1980-11-18 | Thiazolidone derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16291180A JPS5788170A (en) | 1980-11-18 | 1980-11-18 | Thiazolidone derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5788170A true JPS5788170A (en) | 1982-06-01 |
JPH0144708B2 JPH0144708B2 (en) | 1989-09-29 |
Family
ID=15763564
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP16291180A Granted JPS5788170A (en) | 1980-11-18 | 1980-11-18 | Thiazolidone derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5788170A (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4992455A (en) * | 1987-05-22 | 1991-02-12 | Sumitomo Pharmaceuticals Company, Limited | Thiazolidin-4-one derivatives useful for treating diseases caused by platelet activating factor |
US5021435A (en) * | 1988-01-22 | 1991-06-04 | Sumitomo Pharmaceuticals Company, Limited | Certain pyridyl-thiazolidin-4-one having anti-ulcer activity |
US5393741A (en) * | 1990-11-30 | 1995-02-28 | Norsk Hydro A.S. | Acetal derivatives of aromatic aldehydes |
US6506751B1 (en) | 1999-11-12 | 2003-01-14 | Millennium Pharmaceuticals, Inc. | Thiazolidinone compounds useful as chemokine inhibitors |
EP1506180A4 (en) * | 2002-05-17 | 2006-04-05 | Cj Corp | Thiazolidine-4-one derivative, method for preparing the same, and pharmaceutical composition containing the same |
US20170253569A1 (en) * | 2016-03-07 | 2017-09-07 | National Health Research Institutes | Thiazolidinone compounds and use thereof |
-
1980
- 1980-11-18 JP JP16291180A patent/JPS5788170A/en active Granted
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4992455A (en) * | 1987-05-22 | 1991-02-12 | Sumitomo Pharmaceuticals Company, Limited | Thiazolidin-4-one derivatives useful for treating diseases caused by platelet activating factor |
US5021435A (en) * | 1988-01-22 | 1991-06-04 | Sumitomo Pharmaceuticals Company, Limited | Certain pyridyl-thiazolidin-4-one having anti-ulcer activity |
US5393741A (en) * | 1990-11-30 | 1995-02-28 | Norsk Hydro A.S. | Acetal derivatives of aromatic aldehydes |
US6506751B1 (en) | 1999-11-12 | 2003-01-14 | Millennium Pharmaceuticals, Inc. | Thiazolidinone compounds useful as chemokine inhibitors |
EP1506180A4 (en) * | 2002-05-17 | 2006-04-05 | Cj Corp | Thiazolidine-4-one derivative, method for preparing the same, and pharmaceutical composition containing the same |
US20170253569A1 (en) * | 2016-03-07 | 2017-09-07 | National Health Research Institutes | Thiazolidinone compounds and use thereof |
US10544113B2 (en) * | 2016-03-07 | 2020-01-28 | National Health Research Institute | Thiazolidinone compounds and use thereof |
Also Published As
Publication number | Publication date |
---|---|
JPH0144708B2 (en) | 1989-09-29 |
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