JPS568345A - Production of propionic acid derivative and its ester - Google Patents

Production of propionic acid derivative and its ester

Info

Publication number
JPS568345A
JPS568345A JP8345879A JP8345879A JPS568345A JP S568345 A JPS568345 A JP S568345A JP 8345879 A JP8345879 A JP 8345879A JP 8345879 A JP8345879 A JP 8345879A JP S568345 A JPS568345 A JP S568345A
Authority
JP
Japan
Prior art keywords
formula
ester
derivative
selectively
propionic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP8345879A
Other languages
Japanese (ja)
Inventor
Kazuo Endo
Isao Hashima
Kazutaka Arai
Ryozo Sakota
Yasuo Takakuwa
Genichi Dobashi
Katsuyuki Ogura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nissan Chemical Corp
Sagami Chemical Research Institute
Original Assignee
Nissan Chemical Corp
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nissan Chemical Corp, Sagami Chemical Research Institute filed Critical Nissan Chemical Corp
Priority to JP8345879A priority Critical patent/JPS568345A/en
Publication of JPS568345A publication Critical patent/JPS568345A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PURPOSE: 2-Alkylthiopropionic derivative or ester is subjected to selectively reductive desulfurization to produce titled compound having antiinflammatory, analgesic and antipyretic activities through a shortened process.
CONSTITUTION: The use of a nickel-aluminum alloy permits the selectively reductive desulfurization of 2-alkylthiopropionic derivative or ester of formula I (Ar is aromatic group; Y is -CH=CH-, S; R1 is lower alkyl, aryl; R2 is H, lower alkyl) and propionic derivative or ester of formula II is obtained, such as 2-(3-benzoyl- phenyl)propionic acid (Ketoprofen). This catalyst can selectively eliminate only alkyl group safely in high yield. The starting material of formula I is obtained by leading an aromatic aldehyde of formula VI to a compound of formula IX and methylating the compound with a methylating agent in the presence of a base.
COPYRIGHT: (C)1981,JPO&Japio
JP8345879A 1979-07-03 1979-07-03 Production of propionic acid derivative and its ester Pending JPS568345A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP8345879A JPS568345A (en) 1979-07-03 1979-07-03 Production of propionic acid derivative and its ester

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8345879A JPS568345A (en) 1979-07-03 1979-07-03 Production of propionic acid derivative and its ester

Publications (1)

Publication Number Publication Date
JPS568345A true JPS568345A (en) 1981-01-28

Family

ID=13803009

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8345879A Pending JPS568345A (en) 1979-07-03 1979-07-03 Production of propionic acid derivative and its ester

Country Status (1)

Country Link
JP (1) JPS568345A (en)

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