JPS54125699A - Preparation of ( ) dihydroprotoemetine - Google Patents

Preparation of ( ) dihydroprotoemetine

Info

Publication number
JPS54125699A
JPS54125699A JP2982078A JP2982078A JPS54125699A JP S54125699 A JPS54125699 A JP S54125699A JP 2982078 A JP2982078 A JP 2982078A JP 2982078 A JP2982078 A JP 2982078A JP S54125699 A JPS54125699 A JP S54125699A
Authority
JP
Japan
Prior art keywords
compound
dihydroprotoemetine
preparation
dialkoxybenzo
quinolidin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2982078A
Other languages
Japanese (ja)
Inventor
Tetsuji Kametani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Chemiphar Co Ltd
Original Assignee
Nippon Chemiphar Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Chemiphar Co Ltd filed Critical Nippon Chemiphar Co Ltd
Priority to JP2982078A priority Critical patent/JPS54125699A/en
Publication of JPS54125699A publication Critical patent/JPS54125699A/en
Pending legal-status Critical Current

Links

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PURPOSE: To prepare the title compound having carcinostatic activity, economically, by the reduction of (±)-3α-ethyl-2β-formylmethyl-1,2,3,6,7,11b-hexahydro-9,10- dialkoxybenzo[a]quinolidin-4-one.
CONSTITUTION: (±) Dihydroprotoemetine of formula III is prepared by reducing the compound II in a solvent such as THF, pref. refluxing in the presence of Li(A1H4). The compound II can be obtained by the hydrolysis of the compound I (R, R' are lower alkyl).
COPYRIGHT: (C)1979,JPO&Japio
JP2982078A 1978-03-17 1978-03-17 Preparation of ( ) dihydroprotoemetine Pending JPS54125699A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2982078A JPS54125699A (en) 1978-03-17 1978-03-17 Preparation of ( ) dihydroprotoemetine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2982078A JPS54125699A (en) 1978-03-17 1978-03-17 Preparation of ( ) dihydroprotoemetine

Publications (1)

Publication Number Publication Date
JPS54125699A true JPS54125699A (en) 1979-09-29

Family

ID=12286651

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2982078A Pending JPS54125699A (en) 1978-03-17 1978-03-17 Preparation of ( ) dihydroprotoemetine

Country Status (1)

Country Link
JP (1) JPS54125699A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016127133A1 (en) * 2015-02-06 2016-08-11 Neurocrine Biosciences, Inc. [9,10-dimethoxy-3-(2-methylpropyl)-1h,2h,3h,4h,6h,7h,11bh-pyrido-[2,1-a]isoquinolin-2-yl]methanol and compounds, compositions and methods relating thereto

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016127133A1 (en) * 2015-02-06 2016-08-11 Neurocrine Biosciences, Inc. [9,10-dimethoxy-3-(2-methylpropyl)-1h,2h,3h,4h,6h,7h,11bh-pyrido-[2,1-a]isoquinolin-2-yl]methanol and compounds, compositions and methods relating thereto
US9714246B2 (en) 2015-02-06 2017-07-25 Neurocrine Biosciences, Inc. [9,10-dimethoxy-3-(2-methylpropyl)-1H,2H,3H,4H,6H,7H,11bH-pyrido-[2,1-a]isoquinolin-2-yl]methanol and compounds, compositions and methods relating thereto
KR20170113620A (en) * 2015-02-06 2017-10-12 뉴로크린 바이오사이언시즈 인코퍼레이티드 [2, 1-a] isoquinolin-2-yl] methanol and a mixture of [9,10-dimethoxy-3- (2- methylpropyl) -1H, 2H, 3H, 4H, 6H, 7H, 11bH- Compounds, compositions and methods associated therewith
JP2018504437A (en) * 2015-02-06 2018-02-15 ニューロクライン バイオサイエンシーズ，インコーポレイテッド [9,10-Dimethoxy-3- (2-methylpropyl) -1H, 2H, 3H, 4H, 6H, 7H, 11bH-pyrido [2,1-a] isoquinolin-2-yl] methanol and compounds related thereto , Compositions, and methods
US9988382B2 (en) 2015-02-06 2018-06-05 Neurocrine Biosciences, Inc. [9,10-dimethoxy-3-(2-methylpropyl)-1H,2H,3H,4H,6H,7H,11bH-pyrido-[2,1-A]isoquinolin-2-yl]methanol and compounds, compositions and methods relating thereto
US11053242B2 (en) 2015-02-06 2021-07-06 Neurocrine Biosciences, Inc. [9,10-dimethoxy-3-(2-methylpropyl)-1H,2H,3H,4H,6H,7H,11BH-pyrido-[2,1-a]isoquinolin-2-yl]methanol and compounds, compositions and methods relating thereto

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