IE791036L - Thienopyridines and furanopyridines - Google Patents

Thienopyridines and furanopyridines

Info

Publication number
IE791036L
IE791036L IE791036A IE103679A IE791036L IE 791036 L IE791036 L IE 791036L IE 791036 A IE791036 A IE 791036A IE 103679 A IE103679 A IE 103679A IE 791036 L IE791036 L IE 791036L
Authority
IE
Ireland
Prior art keywords
compounds
halogen
furanopyridines
thienopyridines
cyclisation
Prior art date
Application number
IE791036A
Other versions
IE48418B1 (en
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of IE791036L publication Critical patent/IE791036L/en
Publication of IE48418B1 publication Critical patent/IE48418B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Abstract

Therapeutic compositions having, in particular, blood-platelet aggregation inhibiting and anti- inflammatory activities comprising, have as active ingredient, an efficient amount of a thienopyridone derivative having the following general formulae: <IMAGE> in which X is an oxygen or sulfur atom, R is hydrogen or halogen or a C1-4 alkyl radical and Ar represents an aryl or heteroaryl group optionally substituted with at least a halogen atom or a lower alkyl, lower alkoxy, hydroxy, trifluoromethyl or nitro group. The compounds are prepared by cyclisation of a furan or thiophene substituted acrylic acid azide to form the pyridone ring. The compounds other than where R is H, X is 5 and Ar is phenyl are claimed per se. [EP0006772A1]
IE1036/79A 1978-06-22 1979-08-08 Therapeutic composition containing thienopyridone or furopyridone derivatives IE48418B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7818684A FR2429219A1 (en) 1978-06-22 1978-06-22 MEDICINE BASED ON THIENOPYRIDONE OR FUROPYRIDONE DERIVATIVES

Publications (2)

Publication Number Publication Date
IE791036L true IE791036L (en) 1979-12-22
IE48418B1 IE48418B1 (en) 1985-01-09

Family

ID=9209842

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1036/79A IE48418B1 (en) 1978-06-22 1979-08-08 Therapeutic composition containing thienopyridone or furopyridone derivatives

Country Status (11)

Country Link
EP (1) EP0006772B1 (en)
JP (1) JPS552698A (en)
BE (1) BE877157A (en)
CH (1) CH638214A5 (en)
DE (1) DE2961213D1 (en)
DK (1) DK259379A (en)
FR (1) FR2429219A1 (en)
GB (1) GB2023599B (en)
IE (1) IE48418B1 (en)
IT (1) IT1117227B (en)
LU (1) LU81237A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57147852A (en) * 1981-03-10 1982-09-11 Toshiba Corp Mask convergence-type color picture tube
JPS5818845A (en) * 1981-07-24 1983-02-03 Toshiba Corp Color cathode-ray tube
WO1989007329A1 (en) * 1988-02-02 1989-08-10 Dainippon Screen Mfg. Co., Ltd. Slot-type shadow mask
US20040102517A1 (en) * 2001-01-18 2004-05-27 Genhui Chen Novel1,2-diphenylethene derivatives for treatment of immune diseases
EP1594863A1 (en) * 2003-02-11 2005-11-16 Prosidion Limited Tri(cyclo) substituted amide glucokinase activator compounds
US20110275707A1 (en) * 2008-12-19 2011-11-10 Kuo-Hsiung Lee Substituted afpo (6-aryl-4h-furo[3,2-c]pyran-4-one) derivatives as anti-cancer agents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2115006A1 (en) * 1970-11-20 1972-07-07 Anvar 2,7-dinitro and 2-nitro furo 3,2-c pyridine - useful as antibacterials
GB1576511A (en) * 1977-03-29 1980-10-08 Parcor Thieno(2,3 - c) and (3,2 - c) pyridines process for their preparation and therapeutic applications thereof

Also Published As

Publication number Publication date
IT7949482A0 (en) 1979-06-21
FR2429219B1 (en) 1980-10-24
BE877157A (en) 1979-12-21
JPS552698A (en) 1980-01-10
JPS6345394B2 (en) 1988-09-09
GB2023599B (en) 1982-11-03
EP0006772A1 (en) 1980-01-09
FR2429219A1 (en) 1980-01-18
GB2023599A (en) 1980-01-03
DE2961213D1 (en) 1982-01-14
CH638214A5 (en) 1983-09-15
IE48418B1 (en) 1985-01-09
EP0006772B1 (en) 1981-11-04
LU81237A1 (en) 1979-09-10
DK259379A (en) 1979-12-23
IT1117227B (en) 1986-02-17

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Legal Events

Date Code Title Description
MM4A Patent lapsed