JPS57197218A - Central nervous system depressant containing thiazoline- 5-carboxylic acid derivative - Google Patents

Central nervous system depressant containing thiazoline- 5-carboxylic acid derivative

Info

Publication number
JPS57197218A
JPS57197218A JP56081097A JP8109781A JPS57197218A JP S57197218 A JPS57197218 A JP S57197218A JP 56081097 A JP56081097 A JP 56081097A JP 8109781 A JP8109781 A JP 8109781A JP S57197218 A JPS57197218 A JP S57197218A
Authority
JP
Japan
Prior art keywords
compound
carboxylic acid
nervous system
central nervous
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP56081097A
Other languages
Japanese (ja)
Inventor
Katsuyata Igura
Shuichi Soma
Tadayuki Nishibe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NIPPON SODA KK
Nippon Soda Co Ltd
Original Assignee
NIPPON SODA KK
Nippon Soda Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NIPPON SODA KK, Nippon Soda Co Ltd filed Critical NIPPON SODA KK
Priority to JP56081097A priority Critical patent/JPS57197218A/en
Publication of JPS57197218A publication Critical patent/JPS57197218A/en
Pending legal-status Critical Current

Links

Landscapes

  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PURPOSE: To prepare a central nervous system depressant having low toxicity, and useful as a sedative, a sleep assisting drug, etc., by using thiazoline-5-carboxylic acid derivatives (most of which are novel) as active component.
CONSTITUTION: The agent contains the compound of formulaI(R1 is cyclohexyl, phenyl, or 4-chlorophenyl; R2 is R1 or isopropyl; R3 is lower alkyl or methoxymethyl; R4 is lower alkoxy or hydrazino; n is 0 or 1) or its salt, e.g. 5-methoxycarbonyl-4-methyl-3-phenyl-2-phenyliminothiazoline, as an active component. All compounds of formulaIexcluding the one wherein R1 and R2 are phenyl, R3 is methyl, R4 is ethoxy and n is 0 (an intermediate of bactericide) are novel compounds, and e.g. the compound wherein n is 0 can be prepared by reacting the compound of formula II with the compound of formula III (X is halogen). The resultant compound can be converted to the compound wherein n is 0 (1- oxide compound) by oxidation.
COPYRIGHT: (C)1982,JPO&Japio
JP56081097A 1981-05-29 1981-05-29 Central nervous system depressant containing thiazoline- 5-carboxylic acid derivative Pending JPS57197218A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP56081097A JPS57197218A (en) 1981-05-29 1981-05-29 Central nervous system depressant containing thiazoline- 5-carboxylic acid derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56081097A JPS57197218A (en) 1981-05-29 1981-05-29 Central nervous system depressant containing thiazoline- 5-carboxylic acid derivative

Publications (1)

Publication Number Publication Date
JPS57197218A true JPS57197218A (en) 1982-12-03

Family

ID=13736878

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56081097A Pending JPS57197218A (en) 1981-05-29 1981-05-29 Central nervous system depressant containing thiazoline- 5-carboxylic acid derivative

Country Status (1)

Country Link
JP (1) JPS57197218A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0532397A (en) * 1991-07-29 1993-02-09 Sugiyasu Kogyo Kk Correction method for tuning shift in cylinder mechanism of vehicle maintenance lift
WO2007122241A1 (en) * 2006-04-26 2007-11-01 Glaxo Group Limited Compounds which potentiate ampa receptor and uses thereof in medicine
WO2009053448A1 (en) * 2007-10-26 2009-04-30 Glaxo Group Limited Compounds which potentiate ampa receptor and uses thereof in medicine

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0532397A (en) * 1991-07-29 1993-02-09 Sugiyasu Kogyo Kk Correction method for tuning shift in cylinder mechanism of vehicle maintenance lift
WO2007122241A1 (en) * 2006-04-26 2007-11-01 Glaxo Group Limited Compounds which potentiate ampa receptor and uses thereof in medicine
WO2009053448A1 (en) * 2007-10-26 2009-04-30 Glaxo Group Limited Compounds which potentiate ampa receptor and uses thereof in medicine

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