JPS57197218A - Central nervous system depressant containing thiazoline- 5-carboxylic acid derivative - Google Patents
Central nervous system depressant containing thiazoline- 5-carboxylic acid derivativeInfo
- Publication number
- JPS57197218A JPS57197218A JP56081097A JP8109781A JPS57197218A JP S57197218 A JPS57197218 A JP S57197218A JP 56081097 A JP56081097 A JP 56081097A JP 8109781 A JP8109781 A JP 8109781A JP S57197218 A JPS57197218 A JP S57197218A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- carboxylic acid
- nervous system
- central nervous
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Thiazole And Isothizaole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE: To prepare a central nervous system depressant having low toxicity, and useful as a sedative, a sleep assisting drug, etc., by using thiazoline-5-carboxylic acid derivatives (most of which are novel) as active component.
CONSTITUTION: The agent contains the compound of formulaI(R1 is cyclohexyl, phenyl, or 4-chlorophenyl; R2 is R1 or isopropyl; R3 is lower alkyl or methoxymethyl; R4 is lower alkoxy or hydrazino; n is 0 or 1) or its salt, e.g. 5-methoxycarbonyl-4-methyl-3-phenyl-2-phenyliminothiazoline, as an active component. All compounds of formulaIexcluding the one wherein R1 and R2 are phenyl, R3 is methyl, R4 is ethoxy and n is 0 (an intermediate of bactericide) are novel compounds, and e.g. the compound wherein n is 0 can be prepared by reacting the compound of formula II with the compound of formula III (X is halogen). The resultant compound can be converted to the compound wherein n is 0 (1- oxide compound) by oxidation.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56081097A JPS57197218A (en) | 1981-05-29 | 1981-05-29 | Central nervous system depressant containing thiazoline- 5-carboxylic acid derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56081097A JPS57197218A (en) | 1981-05-29 | 1981-05-29 | Central nervous system depressant containing thiazoline- 5-carboxylic acid derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57197218A true JPS57197218A (en) | 1982-12-03 |
Family
ID=13736878
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP56081097A Pending JPS57197218A (en) | 1981-05-29 | 1981-05-29 | Central nervous system depressant containing thiazoline- 5-carboxylic acid derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57197218A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0532397A (en) * | 1991-07-29 | 1993-02-09 | Sugiyasu Kogyo Kk | Correction method for tuning shift in cylinder mechanism of vehicle maintenance lift |
WO2007122241A1 (en) * | 2006-04-26 | 2007-11-01 | Glaxo Group Limited | Compounds which potentiate ampa receptor and uses thereof in medicine |
WO2009053448A1 (en) * | 2007-10-26 | 2009-04-30 | Glaxo Group Limited | Compounds which potentiate ampa receptor and uses thereof in medicine |
-
1981
- 1981-05-29 JP JP56081097A patent/JPS57197218A/en active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0532397A (en) * | 1991-07-29 | 1993-02-09 | Sugiyasu Kogyo Kk | Correction method for tuning shift in cylinder mechanism of vehicle maintenance lift |
WO2007122241A1 (en) * | 2006-04-26 | 2007-11-01 | Glaxo Group Limited | Compounds which potentiate ampa receptor and uses thereof in medicine |
WO2009053448A1 (en) * | 2007-10-26 | 2009-04-30 | Glaxo Group Limited | Compounds which potentiate ampa receptor and uses thereof in medicine |
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