JPS5452068A - 2-azetidinone derivative and its preparation - Google Patents

2-azetidinone derivative and its preparation

Info

Publication number
JPS5452068A
JPS5452068A JP11812077A JP11812077A JPS5452068A JP S5452068 A JPS5452068 A JP S5452068A JP 11812077 A JP11812077 A JP 11812077A JP 11812077 A JP11812077 A JP 11812077A JP S5452068 A JPS5452068 A JP S5452068A
Authority
JP
Japan
Prior art keywords
compound
alkyl
aralkyl
useful
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP11812077A
Other languages
Japanese (ja)
Inventor
Tadashi Hirata
Akira Sato
Yoshihiro Nakamizo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP11812077A priority Critical patent/JPS5452068A/en
Priority to CA000312398A priority patent/CA1145347A/en
Priority to DE19782842466 priority patent/DE2842466A1/en
Priority to FR7827889A priority patent/FR2404632A1/en
Priority to GB7838626A priority patent/GB2006195B/en
Publication of JPS5452068A publication Critical patent/JPS5452068A/en
Priority to US06/142,542 priority patent/US4322345A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:2-Azetidinone derivatives I (R1 is H, OH, alkoxy, substituted or unsubstituted aralkyloxy, etc.; R2 is alkyl, aralkyl; R3 is alkyl aryl, aralkyl, etc.; R4 is alkyl, alkenyl, aryl, etc.; R2-4 may have substitution groups), pref. an optically active 2-azetidinone derivative II.
EXAMPLE: (4S)-t-butyl-α-(4-benzyloxycarbonyl-2-oxoazetidin-1-yl)-α-(acetyl) acetamide.
USE: The compound has β-lactamase-inhibiting activity, and useful for the remedy of infectious diseases together with other antibiotics such as penicillin. It is also useful as an intrmediate f a compound having a skelton similar to the β-lactam antibiotics.
PROCESS: The compound I is prepared by the condensation reaction of the compound III with the compound IV and the compound V in a proper solvent
COPYRIGHT: (C)1979,JPO&Japio
JP11812077A 1977-09-30 1977-09-30 2-azetidinone derivative and its preparation Pending JPS5452068A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP11812077A JPS5452068A (en) 1977-09-30 1977-09-30 2-azetidinone derivative and its preparation
CA000312398A CA1145347A (en) 1977-09-30 1978-09-29 2-azetidinone derivatives
DE19782842466 DE2842466A1 (en) 1977-09-30 1978-09-29 2-AZETIDINONE DERIVATIVES AND PROCESS FOR THEIR PRODUCTION
FR7827889A FR2404632A1 (en) 1977-09-30 1978-09-29 NEW AZETIDINONE DERIVATIVES AND THEIR MANUFACTURING PROCEDURES
GB7838626A GB2006195B (en) 1977-09-30 1978-09-29 2-azetidinone derivatives
US06/142,542 US4322345A (en) 1977-09-30 1980-04-21 2-Azetidinone 4-carboxy derivatives and a process for producing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11812077A JPS5452068A (en) 1977-09-30 1977-09-30 2-azetidinone derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS5452068A true JPS5452068A (en) 1979-04-24

Family

ID=14728519

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11812077A Pending JPS5452068A (en) 1977-09-30 1977-09-30 2-azetidinone derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5452068A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5610165A (en) * 1979-07-05 1981-02-02 Sumitomo Chem Co Ltd Novel beta-lactam compound and its production

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5610165A (en) * 1979-07-05 1981-02-02 Sumitomo Chem Co Ltd Novel beta-lactam compound and its production

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