JPS5452068A - 2-azetidinone derivative and its preparation - Google Patents
2-azetidinone derivative and its preparationInfo
- Publication number
- JPS5452068A JPS5452068A JP11812077A JP11812077A JPS5452068A JP S5452068 A JPS5452068 A JP S5452068A JP 11812077 A JP11812077 A JP 11812077A JP 11812077 A JP11812077 A JP 11812077A JP S5452068 A JPS5452068 A JP S5452068A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- alkyl
- aralkyl
- useful
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:2-Azetidinone derivatives I (R1 is H, OH, alkoxy, substituted or unsubstituted aralkyloxy, etc.; R2 is alkyl, aralkyl; R3 is alkyl aryl, aralkyl, etc.; R4 is alkyl, alkenyl, aryl, etc.; R2-4 may have substitution groups), pref. an optically active 2-azetidinone derivative II.
EXAMPLE: (4S)-t-butyl-α-(4-benzyloxycarbonyl-2-oxoazetidin-1-yl)-α-(acetyl) acetamide.
USE: The compound has β-lactamase-inhibiting activity, and useful for the remedy of infectious diseases together with other antibiotics such as penicillin. It is also useful as an intrmediate f a compound having a skelton similar to the β-lactam antibiotics.
PROCESS: The compound I is prepared by the condensation reaction of the compound III with the compound IV and the compound V in a proper solvent
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11812077A JPS5452068A (en) | 1977-09-30 | 1977-09-30 | 2-azetidinone derivative and its preparation |
CA000312398A CA1145347A (en) | 1977-09-30 | 1978-09-29 | 2-azetidinone derivatives |
DE19782842466 DE2842466A1 (en) | 1977-09-30 | 1978-09-29 | 2-AZETIDINONE DERIVATIVES AND PROCESS FOR THEIR PRODUCTION |
FR7827889A FR2404632A1 (en) | 1977-09-30 | 1978-09-29 | NEW AZETIDINONE DERIVATIVES AND THEIR MANUFACTURING PROCEDURES |
GB7838626A GB2006195B (en) | 1977-09-30 | 1978-09-29 | 2-azetidinone derivatives |
US06/142,542 US4322345A (en) | 1977-09-30 | 1980-04-21 | 2-Azetidinone 4-carboxy derivatives and a process for producing the same |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11812077A JPS5452068A (en) | 1977-09-30 | 1977-09-30 | 2-azetidinone derivative and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5452068A true JPS5452068A (en) | 1979-04-24 |
Family
ID=14728519
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP11812077A Pending JPS5452068A (en) | 1977-09-30 | 1977-09-30 | 2-azetidinone derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5452068A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5610165A (en) * | 1979-07-05 | 1981-02-02 | Sumitomo Chem Co Ltd | Novel beta-lactam compound and its production |
-
1977
- 1977-09-30 JP JP11812077A patent/JPS5452068A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5610165A (en) * | 1979-07-05 | 1981-02-02 | Sumitomo Chem Co Ltd | Novel beta-lactam compound and its production |
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