JPS5750960A - Preparation of novel 4- 1-oxo-2-isoindolinyl acetophenone - Google Patents
Preparation of novel 4- 1-oxo-2-isoindolinyl acetophenoneInfo
- Publication number
- JPS5750960A JPS5750960A JP12752580A JP12752580A JPS5750960A JP S5750960 A JPS5750960 A JP S5750960A JP 12752580 A JP12752580 A JP 12752580A JP 12752580 A JP12752580 A JP 12752580A JP S5750960 A JPS5750960 A JP S5750960A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- agent
- reaction
- isoindolinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: To prepare the titled compound useful as an intermediate of antiphlogistic agent and analgesic agent, easily, economically, in high yield, by cyclizing a compound derived from o-phthalaldehydic acid and p-aminoacetophenone in a low-cost solvent with a reducing agent.
CONSTITUTION: The compound of formula I (R is H or lower alkyl) is used as a raw material, and is cyclized with a reducing agent (e.g. sodium borohydride, potassium borohydride, etc.) in a solvent such as methanol at room temperature or under heating to obtain 4-(1-oxo-2-isoindolinyl)acetophenone of formula II. As an alternative method, the compound of formula II is obtained by the one-bath reaction comprising the reaction of 4-aminoacetophenone with o-phthalaldehydic acid and the cyclization of the resultant compound of formula I without separation from the reaction mixture. The apparatus, steps, and operation of the reaction are simple. The compound of formula II can be converted easily to indoprofen (antiphlogistic agent, analgesic agent) by hydrolysis.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12752580A JPS5750960A (en) | 1980-09-10 | 1980-09-10 | Preparation of novel 4- 1-oxo-2-isoindolinyl acetophenone |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12752580A JPS5750960A (en) | 1980-09-10 | 1980-09-10 | Preparation of novel 4- 1-oxo-2-isoindolinyl acetophenone |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5750960A true JPS5750960A (en) | 1982-03-25 |
JPS632260B2 JPS632260B2 (en) | 1988-01-18 |
Family
ID=14962166
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12752580A Granted JPS5750960A (en) | 1980-09-10 | 1980-09-10 | Preparation of novel 4- 1-oxo-2-isoindolinyl acetophenone |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5750960A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009530306A (en) * | 2006-03-17 | 2009-08-27 | アメリカ合衆国 | Compounds for the treatment of spinal muscular atrophy and other uses |
-
1980
- 1980-09-10 JP JP12752580A patent/JPS5750960A/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009530306A (en) * | 2006-03-17 | 2009-08-27 | アメリカ合衆国 | Compounds for the treatment of spinal muscular atrophy and other uses |
Also Published As
Publication number | Publication date |
---|---|
JPS632260B2 (en) | 1988-01-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS5750960A (en) | Preparation of novel 4- 1-oxo-2-isoindolinyl acetophenone | |
JPS5728046A (en) | Preparation of 4-substituted indole | |
JPS54106478A (en) | Preparation of 1, 3-dioxane derivative | |
JPS55111468A (en) | Preparation of n-benzyl-tetrahydro isoquinoline derivative | |
JPS5750961A (en) | Novel preparation of isoindoline derivative | |
JPS572268A (en) | Preparation of 5- p-chlorobenzoyl -1,4-dimethylpyrrole- 2-acetic acid | |
JPS5716882A (en) | Production of benzo-heteroring derivative | |
JPS5657734A (en) | Novel preparation of 4-acyloxy-beta-ionone | |
JPS56115776A (en) | Preparation of 2-bromo-trifluoromethylpyridine | |
JPS57126427A (en) | Preparation of 1-substituted-azulene derivative | |
JPS5750962A (en) | Novel preparation of isoindoline derivative | |
JPS5436274A (en) | Preparation of propiophenone derivative | |
JPS55120540A (en) | Preparation of 2-substituted-3-oxo-cyclopentylacetic acid ester | |
JPS55143925A (en) | Preparation of cyclopentenolone | |
JPS5432476A (en) | Preparation of 3-aminopyridines | |
JPS5615236A (en) | Production of cyclopentenolone | |
JPS5746965A (en) | Novel method of producing 4-benzazonine derivative | |
JPS5536431A (en) | Preparation of farnesylacetic acid | |
JPS52153914A (en) | Preparation of butene-1,4-dicarboxylic acid diesters | |
JPS54144393A (en) | Preparation of imidazo2,1-bthiazole derivative | |
JPS5492942A (en) | Production of 3-amino-2-cyclohexenone | |
JPS5569580A (en) | Preparation of nitrogen-containing polycyclic compound | |
JPS57106645A (en) | Preparation of 4-bromo-3-methylchrotonic acid ester | |
JPS5492947A (en) | Production of bicyclo10.3.0pentadeca-1(12)-ene-13-one | |
JPS55143963A (en) | Novel nitro compound and its preparation |