JPS5746965A - Novel method of producing 4-benzazonine derivative - Google Patents
Novel method of producing 4-benzazonine derivativeInfo
- Publication number
- JPS5746965A JPS5746965A JP12302080A JP12302080A JPS5746965A JP S5746965 A JPS5746965 A JP S5746965A JP 12302080 A JP12302080 A JP 12302080A JP 12302080 A JP12302080 A JP 12302080A JP S5746965 A JPS5746965 A JP S5746965A
- Authority
- JP
- Japan
- Prior art keywords
- derivative
- reaction
- acid
- perhydroazepin
- solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
PURPOSE: A perhydroazepin derivative is used as a starting material to effect its dehydrative cyclization reaction to easily produce the titled substance having important pharmacological activities such as analgesic, antitussive and so on with no need of many steps such as demethylation and lessened loss.
CONSTITUTION: A perhydroazepin derivative of formula I (R, R1, R2, R3 are H, lower alkyl) is used as a starting material to effect the dehydrative cyclization reaction using a Lewis acid to produce the objective compound of formula II. The preferable example of the Lewis acid is hydrobromic acid or polyphosphoric acid and the amount is 5W15 times the weight of the substance to be dehydrated. The dehydration reaction temperature is 0W120°C. In case of using a solvent such as water or acetic acid, the reaction progresses smoothly, but the reaction time becomes longer than in case of using no solvent.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12302080A JPS5746965A (en) | 1980-09-05 | 1980-09-05 | Novel method of producing 4-benzazonine derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12302080A JPS5746965A (en) | 1980-09-05 | 1980-09-05 | Novel method of producing 4-benzazonine derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5746965A true JPS5746965A (en) | 1982-03-17 |
Family
ID=14850229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP12302080A Pending JPS5746965A (en) | 1980-09-05 | 1980-09-05 | Novel method of producing 4-benzazonine derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5746965A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6094207A (en) * | 1983-10-26 | 1985-05-27 | クツシユマン・インダストリーズ・インコーポレイテツド | Chuck |
| WO2017038656A1 (en) * | 2015-08-28 | 2017-03-09 | 日本臓器製薬株式会社 | Method for producing novel 4-benzazonine derivative |
-
1980
- 1980-09-05 JP JP12302080A patent/JPS5746965A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6094207A (en) * | 1983-10-26 | 1985-05-27 | クツシユマン・インダストリーズ・インコーポレイテツド | Chuck |
| WO2017038656A1 (en) * | 2015-08-28 | 2017-03-09 | 日本臓器製薬株式会社 | Method for producing novel 4-benzazonine derivative |
| JPWO2017038656A1 (en) * | 2015-08-28 | 2018-06-14 | 日本臓器製薬株式会社 | Method for producing novel 4-benzoazonin derivative |
| US10703725B2 (en) | 2015-08-28 | 2020-07-07 | Nippon Zoki Pharmaceutical Co., Ltd. | Process for producing novel 4-benzoazonine derivatives |
| TWI711604B (en) * | 2015-08-28 | 2020-12-01 | 日商日本臟器製藥股份有限公司 | Method for producing novel 4-benzoazonine derivatives |
| JP2021098744A (en) * | 2015-08-28 | 2021-07-01 | 日本臓器製薬株式会社 | Method for producing novel 4-benzazonine derivative |
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