JPS5620577A - 4- n-alkylanilino quinazoline derivative and its preparation - Google Patents

4- n-alkylanilino quinazoline derivative and its preparation

Info

Publication number
JPS5620577A
JPS5620577A JP9581579A JP9581579A JPS5620577A JP S5620577 A JPS5620577 A JP S5620577A JP 9581579 A JP9581579 A JP 9581579A JP 9581579 A JP9581579 A JP 9581579A JP S5620577 A JPS5620577 A JP S5620577A
Authority
JP
Japan
Prior art keywords
formula
derivative
halogen
acid addition
addition salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP9581579A
Other languages
Japanese (ja)
Other versions
JPS626715B2 (en
Inventor
Shinsaku Kobayashi
Katsuo Kamoshita
Shigeki Nagai
Takeo Honda
Kiroku Oda
Katsutoshi Fujii
Takashi Furubayashi
Mikio Kojima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Ube Corp
Original Assignee
Sankyo Co Ltd
Ube Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd, Ube Industries Ltd filed Critical Sankyo Co Ltd
Priority to JP9581579A priority Critical patent/JPS5620577A/en
Publication of JPS5620577A publication Critical patent/JPS5620577A/en
Publication of JPS626715B2 publication Critical patent/JPS626715B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:The titled compound expressed by formula I (R1 is H, halogen, CF3 or NO2; R2 is H, lower alkyl, lower alkoxy or halogen; R3 is lower alkyl group), and its pharmacologically acceptable acid addition salt.
EXAMPLE: 4-(N-methylanilino)-7-trifluoromethylquinazoline.
USE: An analgesic and anti-inflammatory agent usually in a daily dose of 50W2,000mg per adult administered once or several times.
PROCESS: A 4-halogenoquinazoline derivative of formula II is reacted with an equimolar amount of an N-alkylaniline derivative of formula III in a solvent under heating to give the compound of formula I, which can be converted into a pharmacologically acceptable acid addition salt, if necessary, by the conventional method.
COPYRIGHT: (C)1981,JPO&Japio
JP9581579A 1979-07-27 1979-07-27 4- n-alkylanilino quinazoline derivative and its preparation Granted JPS5620577A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP9581579A JPS5620577A (en) 1979-07-27 1979-07-27 4- n-alkylanilino quinazoline derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9581579A JPS5620577A (en) 1979-07-27 1979-07-27 4- n-alkylanilino quinazoline derivative and its preparation

Publications (2)

Publication Number Publication Date
JPS5620577A true JPS5620577A (en) 1981-02-26
JPS626715B2 JPS626715B2 (en) 1987-02-13

Family

ID=14147911

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9581579A Granted JPS5620577A (en) 1979-07-27 1979-07-27 4- n-alkylanilino quinazoline derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5620577A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57144266A (en) * 1981-03-04 1982-09-06 Sankyo Co Ltd 4-anilinoquinazoline derivative, its preparation, and analgesic and antiphlogistic agent containing said derivative as active component
US5457105A (en) * 1992-01-20 1995-10-10 Zeneca Limited Quinazoline derivatives useful for treatment of neoplastic disease
US5475001A (en) * 1993-07-19 1995-12-12 Zeneca Limited Quinazoline derivatives

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57144266A (en) * 1981-03-04 1982-09-06 Sankyo Co Ltd 4-anilinoquinazoline derivative, its preparation, and analgesic and antiphlogistic agent containing said derivative as active component
US5457105A (en) * 1992-01-20 1995-10-10 Zeneca Limited Quinazoline derivatives useful for treatment of neoplastic disease
US5616582A (en) * 1992-01-20 1997-04-01 Zeneca Limited Quinazoline derivatives as anti-proliferative agents
US5475001A (en) * 1993-07-19 1995-12-12 Zeneca Limited Quinazoline derivatives

Also Published As

Publication number Publication date
JPS626715B2 (en) 1987-02-13

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