JPS5620577A - 4- n-alkylanilino quinazoline derivative and its preparation - Google Patents
4- n-alkylanilino quinazoline derivative and its preparationInfo
- Publication number
- JPS5620577A JPS5620577A JP9581579A JP9581579A JPS5620577A JP S5620577 A JPS5620577 A JP S5620577A JP 9581579 A JP9581579 A JP 9581579A JP 9581579 A JP9581579 A JP 9581579A JP S5620577 A JPS5620577 A JP S5620577A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- derivative
- halogen
- acid addition
- addition salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:The titled compound expressed by formula I (R1 is H, halogen, CF3 or NO2; R2 is H, lower alkyl, lower alkoxy or halogen; R3 is lower alkyl group), and its pharmacologically acceptable acid addition salt.
EXAMPLE: 4-(N-methylanilino)-7-trifluoromethylquinazoline.
USE: An analgesic and anti-inflammatory agent usually in a daily dose of 50W2,000mg per adult administered once or several times.
PROCESS: A 4-halogenoquinazoline derivative of formula II is reacted with an equimolar amount of an N-alkylaniline derivative of formula III in a solvent under heating to give the compound of formula I, which can be converted into a pharmacologically acceptable acid addition salt, if necessary, by the conventional method.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9581579A JPS5620577A (en) | 1979-07-27 | 1979-07-27 | 4- n-alkylanilino quinazoline derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9581579A JPS5620577A (en) | 1979-07-27 | 1979-07-27 | 4- n-alkylanilino quinazoline derivative and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5620577A true JPS5620577A (en) | 1981-02-26 |
JPS626715B2 JPS626715B2 (en) | 1987-02-13 |
Family
ID=14147911
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9581579A Granted JPS5620577A (en) | 1979-07-27 | 1979-07-27 | 4- n-alkylanilino quinazoline derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5620577A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57144266A (en) * | 1981-03-04 | 1982-09-06 | Sankyo Co Ltd | 4-anilinoquinazoline derivative, its preparation, and analgesic and antiphlogistic agent containing said derivative as active component |
US5457105A (en) * | 1992-01-20 | 1995-10-10 | Zeneca Limited | Quinazoline derivatives useful for treatment of neoplastic disease |
US5475001A (en) * | 1993-07-19 | 1995-12-12 | Zeneca Limited | Quinazoline derivatives |
-
1979
- 1979-07-27 JP JP9581579A patent/JPS5620577A/en active Granted
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57144266A (en) * | 1981-03-04 | 1982-09-06 | Sankyo Co Ltd | 4-anilinoquinazoline derivative, its preparation, and analgesic and antiphlogistic agent containing said derivative as active component |
US5457105A (en) * | 1992-01-20 | 1995-10-10 | Zeneca Limited | Quinazoline derivatives useful for treatment of neoplastic disease |
US5616582A (en) * | 1992-01-20 | 1997-04-01 | Zeneca Limited | Quinazoline derivatives as anti-proliferative agents |
US5475001A (en) * | 1993-07-19 | 1995-12-12 | Zeneca Limited | Quinazoline derivatives |
Also Published As
Publication number | Publication date |
---|---|
JPS626715B2 (en) | 1987-02-13 |
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