JPS5695188A - Theophyllin derivative and its production - Google Patents

Theophyllin derivative and its production

Info

Publication number
JPS5695188A
JPS5695188A JP17042979A JP17042979A JPS5695188A JP S5695188 A JPS5695188 A JP S5695188A JP 17042979 A JP17042979 A JP 17042979A JP 17042979 A JP17042979 A JP 17042979A JP S5695188 A JPS5695188 A JP S5695188A
Authority
JP
Japan
Prior art keywords
formula
theophyllin
reaction
halogen
integer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP17042979A
Other languages
Japanese (ja)
Inventor
Noriyasu Hirose
Shizuo Kuriyama
Tadao Shoji
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Priority to JP17042979A priority Critical patent/JPS5695188A/en
Publication of JPS5695188A publication Critical patent/JPS5695188A/en
Pending legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:Theophyllin derivatives of formula I [R1 is lower alkyl, benzyl; Z is formula IV (R2 is H, halogen; m is integer of 0W2); n is integer of 2 or 3] and its acid adduct.
EXAMPLE: 7-Methyl-8-[ 3-(4-phenylpiperazin-1-yl)propyloxy ]theophyllin maleate.
USE: They are used to treat various kinds of allergic respiratory diseases and of allergic dermatopathy. They are extremely low-toxicity and show durable and conspicuous activities of antihistamine, anticholinergy antiserotonin, muscle relaxation and neurolepsy.
PREPARATION: The reaction of 8-halogenotheophyllin of formula II (X is halogen) with a piperazine of formula III gives the compound of formula I. The addition of an acid acceptor such as pyridine to the reaction system assures the more smooth reaction.
COPYRIGHT: (C)1981,JPO&Japio
JP17042979A 1979-12-28 1979-12-28 Theophyllin derivative and its production Pending JPS5695188A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP17042979A JPS5695188A (en) 1979-12-28 1979-12-28 Theophyllin derivative and its production

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP17042979A JPS5695188A (en) 1979-12-28 1979-12-28 Theophyllin derivative and its production

Publications (1)

Publication Number Publication Date
JPS5695188A true JPS5695188A (en) 1981-08-01

Family

ID=15904745

Family Applications (1)

Application Number Title Priority Date Filing Date
JP17042979A Pending JPS5695188A (en) 1979-12-28 1979-12-28 Theophyllin derivative and its production

Country Status (1)

Country Link
JP (1) JPS5695188A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5021574A (en) * 1988-03-03 1991-06-04 Ortho Pharmaceutical Corporation 6-substituted purinyl piperazine derivatives
US5164390A (en) * 1988-03-03 1992-11-17 Ortho Pharmaceutical Corporation 6-substituted purinyl piperazine derivatives
CN104130259A (en) * 2014-08-08 2014-11-05 石药集团新诺威制药股份有限公司 Ring-closure reaction method of caffeine intermediate 1,3-dimethyl-4-amino-5-formyl aminoureazine (FAU)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5021574A (en) * 1988-03-03 1991-06-04 Ortho Pharmaceutical Corporation 6-substituted purinyl piperazine derivatives
US5164390A (en) * 1988-03-03 1992-11-17 Ortho Pharmaceutical Corporation 6-substituted purinyl piperazine derivatives
CN104130259A (en) * 2014-08-08 2014-11-05 石药集团新诺威制药股份有限公司 Ring-closure reaction method of caffeine intermediate 1,3-dimethyl-4-amino-5-formyl aminoureazine (FAU)

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