JPS5695188A - Theophyllin derivative and its production - Google Patents
Theophyllin derivative and its productionInfo
- Publication number
- JPS5695188A JPS5695188A JP17042979A JP17042979A JPS5695188A JP S5695188 A JPS5695188 A JP S5695188A JP 17042979 A JP17042979 A JP 17042979A JP 17042979 A JP17042979 A JP 17042979A JP S5695188 A JPS5695188 A JP S5695188A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- theophyllin
- reaction
- halogen
- integer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:Theophyllin derivatives of formula I [R1 is lower alkyl, benzyl; Z is formula IV (R2 is H, halogen; m is integer of 0W2); n is integer of 2 or 3] and its acid adduct.
EXAMPLE: 7-Methyl-8-[ 3-(4-phenylpiperazin-1-yl)propyloxy ]theophyllin maleate.
USE: They are used to treat various kinds of allergic respiratory diseases and of allergic dermatopathy. They are extremely low-toxicity and show durable and conspicuous activities of antihistamine, anticholinergy antiserotonin, muscle relaxation and neurolepsy.
PREPARATION: The reaction of 8-halogenotheophyllin of formula II (X is halogen) with a piperazine of formula III gives the compound of formula I. The addition of an acid acceptor such as pyridine to the reaction system assures the more smooth reaction.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17042979A JPS5695188A (en) | 1979-12-28 | 1979-12-28 | Theophyllin derivative and its production |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17042979A JPS5695188A (en) | 1979-12-28 | 1979-12-28 | Theophyllin derivative and its production |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5695188A true JPS5695188A (en) | 1981-08-01 |
Family
ID=15904745
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP17042979A Pending JPS5695188A (en) | 1979-12-28 | 1979-12-28 | Theophyllin derivative and its production |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5695188A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5021574A (en) * | 1988-03-03 | 1991-06-04 | Ortho Pharmaceutical Corporation | 6-substituted purinyl piperazine derivatives |
US5164390A (en) * | 1988-03-03 | 1992-11-17 | Ortho Pharmaceutical Corporation | 6-substituted purinyl piperazine derivatives |
CN104130259A (en) * | 2014-08-08 | 2014-11-05 | 石药集团新诺威制药股份有限公司 | Ring-closure reaction method of caffeine intermediate 1,3-dimethyl-4-amino-5-formyl aminoureazine (FAU) |
-
1979
- 1979-12-28 JP JP17042979A patent/JPS5695188A/en active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5021574A (en) * | 1988-03-03 | 1991-06-04 | Ortho Pharmaceutical Corporation | 6-substituted purinyl piperazine derivatives |
US5164390A (en) * | 1988-03-03 | 1992-11-17 | Ortho Pharmaceutical Corporation | 6-substituted purinyl piperazine derivatives |
CN104130259A (en) * | 2014-08-08 | 2014-11-05 | 石药集团新诺威制药股份有限公司 | Ring-closure reaction method of caffeine intermediate 1,3-dimethyl-4-amino-5-formyl aminoureazine (FAU) |
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