JPS5583772A - N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt - Google Patents

N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt

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Publication number
JPS5583772A
JPS5583772A JP15829078A JP15829078A JPS5583772A JP S5583772 A JPS5583772 A JP S5583772A JP 15829078 A JP15829078 A JP 15829078A JP 15829078 A JP15829078 A JP 15829078A JP S5583772 A JPS5583772 A JP S5583772A
Authority
JP
Japan
Prior art keywords
compound
acid addition
addition salt
trimethoxybenzylpiperazine
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP15829078A
Other languages
Japanese (ja)
Inventor
Hiroshi Otaka
Kazuo Miyake
Yoshiaki Fujimoto
Tominori Morita
Keizo Ito
Hisashi Nose
Goro Tsukamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanebo Ltd
Original Assignee
Kanebo Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanebo Ltd filed Critical Kanebo Ltd
Priority to JP15829078A priority Critical patent/JPS5583772A/en
Publication of JPS5583772A publication Critical patent/JPS5583772A/en
Pending legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound of formula I and its acid addition salt (R1W5 are H, lower alkyl, lower alkoxy, nitro, or halogen; n is 1 or 2).
EXAMPLE: 1-(2,3,4-Trimethoxybenzyl)-4-(2-benzoyl)ethylpiperazine.
USE: Low-toxic drug having coronary vessel blood flow increasing, calcium antagonistic activity. Stronger activity than trimethazidine.
PROCESS: A compound I wherein n is 1, is prepared by halogenating a compound II to a compound III, and reacting the compound III with trimethazidine III or its acid addition salt. Another form of the compound I wherein n is 2, is prepared by reacting a compound II with a compound IV and paraformaldehyde.
COPYRIGHT: (C)1980,JPO&Japio
JP15829078A 1978-12-20 1978-12-20 N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt Pending JPS5583772A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15829078A JPS5583772A (en) 1978-12-20 1978-12-20 N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15829078A JPS5583772A (en) 1978-12-20 1978-12-20 N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt

Publications (1)

Publication Number Publication Date
JPS5583772A true JPS5583772A (en) 1980-06-24

Family

ID=15668360

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15829078A Pending JPS5583772A (en) 1978-12-20 1978-12-20 N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt

Country Status (1)

Country Link
JP (1) JPS5583772A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996016052A3 (en) * 1994-11-17 1996-08-01 Molecular Geriatrics Corp Certain substituted 1-aryl-3-piperazin-1'-yl propanones

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996016052A3 (en) * 1994-11-17 1996-08-01 Molecular Geriatrics Corp Certain substituted 1-aryl-3-piperazin-1'-yl propanones
US5693804A (en) * 1994-11-17 1997-12-02 Molecular Geriatrics Corporation Substituted 1-aryl-3-piperazin-1'-yl propanones
AU711703B2 (en) * 1994-11-17 1999-10-21 Molecular Geriatrics Corporation Certain substituted 1-aryl-3-piperazin-1'-yl propanones

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