JPS5583772A - N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt - Google Patents
N-substituted trimethoxybenzylpiperazine derivative and its acid addition saltInfo
- Publication number
- JPS5583772A JPS5583772A JP15829078A JP15829078A JPS5583772A JP S5583772 A JPS5583772 A JP S5583772A JP 15829078 A JP15829078 A JP 15829078A JP 15829078 A JP15829078 A JP 15829078A JP S5583772 A JPS5583772 A JP S5583772A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- acid addition
- addition salt
- trimethoxybenzylpiperazine
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A compound of formula I and its acid addition salt (R1W5 are H, lower alkyl, lower alkoxy, nitro, or halogen; n is 1 or 2).
EXAMPLE: 1-(2,3,4-Trimethoxybenzyl)-4-(2-benzoyl)ethylpiperazine.
USE: Low-toxic drug having coronary vessel blood flow increasing, calcium antagonistic activity. Stronger activity than trimethazidine.
PROCESS: A compound I wherein n is 1, is prepared by halogenating a compound II to a compound III, and reacting the compound III with trimethazidine III or its acid addition salt. Another form of the compound I wherein n is 2, is prepared by reacting a compound II with a compound IV and paraformaldehyde.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15829078A JPS5583772A (en) | 1978-12-20 | 1978-12-20 | N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15829078A JPS5583772A (en) | 1978-12-20 | 1978-12-20 | N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5583772A true JPS5583772A (en) | 1980-06-24 |
Family
ID=15668360
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15829078A Pending JPS5583772A (en) | 1978-12-20 | 1978-12-20 | N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5583772A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996016052A3 (en) * | 1994-11-17 | 1996-08-01 | Molecular Geriatrics Corp | Certain substituted 1-aryl-3-piperazin-1'-yl propanones |
-
1978
- 1978-12-20 JP JP15829078A patent/JPS5583772A/en active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996016052A3 (en) * | 1994-11-17 | 1996-08-01 | Molecular Geriatrics Corp | Certain substituted 1-aryl-3-piperazin-1'-yl propanones |
US5693804A (en) * | 1994-11-17 | 1997-12-02 | Molecular Geriatrics Corporation | Substituted 1-aryl-3-piperazin-1'-yl propanones |
AU711703B2 (en) * | 1994-11-17 | 1999-10-21 | Molecular Geriatrics Corporation | Certain substituted 1-aryl-3-piperazin-1'-yl propanones |
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