JPS5583773A - N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt - Google Patents

N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt

Info

Publication number
JPS5583773A
JPS5583773A JP15828978A JP15828978A JPS5583773A JP S5583773 A JPS5583773 A JP S5583773A JP 15828978 A JP15828978 A JP 15828978A JP 15828978 A JP15828978 A JP 15828978A JP S5583773 A JPS5583773 A JP S5583773A
Authority
JP
Japan
Prior art keywords
compound
trimethazidine
addition salt
acid addition
trimethoxybenzylpiperazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP15828978A
Other languages
Japanese (ja)
Inventor
Hiroshi Otaka
Kazuo Miyake
Yoshiaki Fujimoto
Tominori Morita
Keizo Ito
Hisashi Nose
Goro Tsukamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanebo Ltd
Original Assignee
Kanebo Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanebo Ltd filed Critical Kanebo Ltd
Priority to JP15828978A priority Critical patent/JPS5583773A/en
Publication of JPS5583773A publication Critical patent/JPS5583773A/en
Pending legal-status Critical Current

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Abstract

NEW MATERIAL:A compound I and its acid addition salt (R1W5 are H, lower alkyl, lower alkoxy, nitro, or halogen; one of X and Y is methylene and the other is oxygen atom).
EXAMPLE: 1-(2,3,4-Trimethoxybenzyl)-4-phenoxyacetylpiperazine.
USE: A low-toxic drug having coronary vessel blood flow increasing, calcium antagonistic activity. Stronger activity than trimethazidine.
PROCESS: A compound I wherein X is CH2 and Y is O, is prepared by acylating trimethazidine with a carboxylic acid II or its acid chloride, etc. Another form of compound I wherein X is O and Y is CH2, is prepared by reacting an alcohol III with phosgen and further reacting the resulting chloroformate compound with trimethazidine.
COPYRIGHT: (C)1980,JPO&Japio
JP15828978A 1978-12-20 1978-12-20 N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt Pending JPS5583773A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15828978A JPS5583773A (en) 1978-12-20 1978-12-20 N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15828978A JPS5583773A (en) 1978-12-20 1978-12-20 N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt

Publications (1)

Publication Number Publication Date
JPS5583773A true JPS5583773A (en) 1980-06-24

Family

ID=15668337

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15828978A Pending JPS5583773A (en) 1978-12-20 1978-12-20 N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt

Country Status (1)

Country Link
JP (1) JPS5583773A (en)

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