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Kanebo Ltd
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Kanebo Ltd
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Publication date
Application filed by Kanebo LtdfiledCriticalKanebo Ltd
Priority to JP15828978ApriorityCriticalpatent/JPS5583773A/en
Publication of JPS5583773ApublicationCriticalpatent/JPS5583773A/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
NEW MATERIAL:A compound I and its acid addition salt (R1W5 are H, lower alkyl, lower alkoxy, nitro, or halogen; one of X and Y is methylene and the other is oxygen atom).
USE: A low-toxic drug having coronary vessel blood flow increasing, calcium antagonistic activity. Stronger activity than trimethazidine.
PROCESS: A compound I wherein X is CH2 and Y is O, is prepared by acylating trimethazidine with a carboxylic acid II or its acid chloride, etc. Another form of compound I wherein X is O and Y is CH2, is prepared by reacting an alcohol III with phosgen and further reacting the resulting chloroformate compound with trimethazidine.
COPYRIGHT: (C)1980,JPO&Japio
JP15828978A1978-12-201978-12-20N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt
PendingJPS5583773A
(en)
THEOPHYLLINE-7-ACETATE OF D,L-TRANSSOBREROL WITH MUCOSECRETOLYTE-FLUIDIZING AND ANTIBRONCHOSPASTIC ACTION, A PROCESS FOR ITS PRODUCTION AND PHARMACEUTICAL PREPARATIONS.