Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Kanebo Ltd
Original Assignee
Kanebo Ltd
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Publication date
Application filed by Kanebo LtdfiledCriticalKanebo Ltd
Priority to JP15829278ApriorityCriticalpatent/JPS5583770A/en
Publication of JPS5583770ApublicationCriticalpatent/JPS5583770A/en
NEW MATERIAL:An N-substituted trimethoxybenzylpiperazine derivative of formula I or its acid addition salt (R1-5 are H, lower alkyl, lower alkoxy, nitro, or halogen; R6 is H or lower alkyl).
USE: Low-toxic drug having coronary vessel blood flow increasing and calcium antagonistic activity. More effective than trimethazidine.
PROCESS: Trimethazidine or its acid addition salt is condensed with a substituted acetophenone II to aford a compound III, which is reduced, or reacted with R7MgX to obtain the objective compound I.
COPYRIGHT: (C)1980,JPO&Japio
JP15829278A1978-12-201978-12-20N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt
PendingJPS5583770A
(en)