JPS5583770A - N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt - Google Patents

N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt

Info

Publication number
JPS5583770A
JPS5583770A JP15829278A JP15829278A JPS5583770A JP S5583770 A JPS5583770 A JP S5583770A JP 15829278 A JP15829278 A JP 15829278A JP 15829278 A JP15829278 A JP 15829278A JP S5583770 A JPS5583770 A JP S5583770A
Authority
JP
Japan
Prior art keywords
acid addition
addition salt
substituted
trimethoxybenzylpiperazine
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP15829278A
Other languages
Japanese (ja)
Inventor
Hiroshi Otaka
Kazuo Miyake
Yoshiaki Fujimoto
Tominori Morita
Keizo Ito
Hisashi Nose
Goro Tsukamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanebo Ltd
Original Assignee
Kanebo Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanebo Ltd filed Critical Kanebo Ltd
Priority to JP15829278A priority Critical patent/JPS5583770A/en
Publication of JPS5583770A publication Critical patent/JPS5583770A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:An N-substituted trimethoxybenzylpiperazine derivative of formula I or its acid addition salt (R1-5 are H, lower alkyl, lower alkoxy, nitro, or halogen; R6 is H or lower alkyl).
EXAMPLE: 1-(2,3,4-Trimethoxybenzyl)-4-(3-hydroxy-3-phenylpropyl)piperazine.
USE: Low-toxic drug having coronary vessel blood flow increasing and calcium antagonistic activity. More effective than trimethazidine.
PROCESS: Trimethazidine or its acid addition salt is condensed with a substituted acetophenone II to aford a compound III, which is reduced, or reacted with R7MgX to obtain the objective compound I.
COPYRIGHT: (C)1980,JPO&Japio
JP15829278A 1978-12-20 1978-12-20 N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt Pending JPS5583770A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15829278A JPS5583770A (en) 1978-12-20 1978-12-20 N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15829278A JPS5583770A (en) 1978-12-20 1978-12-20 N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt

Publications (1)

Publication Number Publication Date
JPS5583770A true JPS5583770A (en) 1980-06-24

Family

ID=15668410

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15829278A Pending JPS5583770A (en) 1978-12-20 1978-12-20 N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt

Country Status (1)

Country Link
JP (1) JPS5583770A (en)

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