JPS5583771A - N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt - Google Patents

N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt

Info

Publication number
JPS5583771A
JPS5583771A JP15829178A JP15829178A JPS5583771A JP S5583771 A JPS5583771 A JP S5583771A JP 15829178 A JP15829178 A JP 15829178A JP 15829178 A JP15829178 A JP 15829178A JP S5583771 A JPS5583771 A JP S5583771A
Authority
JP
Japan
Prior art keywords
compound
addition salt
acid addition
trimethazidine
condensed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP15829178A
Other languages
Japanese (ja)
Inventor
Hiroshi Otaka
Kazuo Miyake
Yoshiaki Fujimoto
Tominori Morita
Keizo Ito
Hisashi Nose
Goro Tsukamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanebo Ltd
Original Assignee
Kanebo Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanebo Ltd filed Critical Kanebo Ltd
Priority to JP15829178A priority Critical patent/JPS5583771A/en
Publication of JPS5583771A publication Critical patent/JPS5583771A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:A compound of formula I or its acid addition salt (R1W5 are H, lower alkyl, lower alkoxy, nitro, or halogen; X is ethylene, propylene or ethenylene; when X is ethenylene, at least one of R1W5 is not H).
EXAMPLE: 1-(2,3,4-Trimethoxybenzyl)-4-(4-phenylpropyl)piperazine.
USE: Low-toxic drug having coronary vessel blood flow increasing and calcium antagonistic activity. Stronger activity than trimethazidine.
PROCESS: Trimethazidine is condensed with a carboxylic acid II or its halogenide to afford a compound III, which is reduced or condensed to obtain the compound I. As an alternative method, trimethazidine is condensed with an alcohol IV or its halogenide to obtain the compound I.
COPYRIGHT: (C)1980,JPO&Japio
JP15829178A 1978-12-20 1978-12-20 N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt Pending JPS5583771A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15829178A JPS5583771A (en) 1978-12-20 1978-12-20 N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15829178A JPS5583771A (en) 1978-12-20 1978-12-20 N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt

Publications (1)

Publication Number Publication Date
JPS5583771A true JPS5583771A (en) 1980-06-24

Family

ID=15668385

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15829178A Pending JPS5583771A (en) 1978-12-20 1978-12-20 N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt

Country Status (1)

Country Link
JP (1) JPS5583771A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995004050A1 (en) * 1993-07-28 1995-02-09 Santen Pharmaceutical Co., Ltd. Novel 1,4-di(phenylalkyl)piperazine derivative

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995004050A1 (en) * 1993-07-28 1995-02-09 Santen Pharmaceutical Co., Ltd. Novel 1,4-di(phenylalkyl)piperazine derivative
US5736546A (en) * 1993-07-28 1998-04-07 Santen Pharmaceutical Co., Ltd. 1,4-(diphenlyalkyl) piperazine derivatives
CN1042029C (en) * 1993-07-28 1999-02-10 参天制药株式会社 Novel 1,4-di(phenylalkyl)piperazine derivative

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