JPS5583771A - N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt - Google Patents
N-substituted trimethoxybenzylpiperazine derivative and its acid addition saltInfo
- Publication number
- JPS5583771A JPS5583771A JP15829178A JP15829178A JPS5583771A JP S5583771 A JPS5583771 A JP S5583771A JP 15829178 A JP15829178 A JP 15829178A JP 15829178 A JP15829178 A JP 15829178A JP S5583771 A JPS5583771 A JP S5583771A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- addition salt
- acid addition
- trimethazidine
- condensed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:A compound of formula I or its acid addition salt (R1W5 are H, lower alkyl, lower alkoxy, nitro, or halogen; X is ethylene, propylene or ethenylene; when X is ethenylene, at least one of R1W5 is not H).
EXAMPLE: 1-(2,3,4-Trimethoxybenzyl)-4-(4-phenylpropyl)piperazine.
USE: Low-toxic drug having coronary vessel blood flow increasing and calcium antagonistic activity. Stronger activity than trimethazidine.
PROCESS: Trimethazidine is condensed with a carboxylic acid II or its halogenide to afford a compound III, which is reduced or condensed to obtain the compound I. As an alternative method, trimethazidine is condensed with an alcohol IV or its halogenide to obtain the compound I.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15829178A JPS5583771A (en) | 1978-12-20 | 1978-12-20 | N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15829178A JPS5583771A (en) | 1978-12-20 | 1978-12-20 | N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5583771A true JPS5583771A (en) | 1980-06-24 |
Family
ID=15668385
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15829178A Pending JPS5583771A (en) | 1978-12-20 | 1978-12-20 | N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5583771A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995004050A1 (en) * | 1993-07-28 | 1995-02-09 | Santen Pharmaceutical Co., Ltd. | Novel 1,4-di(phenylalkyl)piperazine derivative |
-
1978
- 1978-12-20 JP JP15829178A patent/JPS5583771A/en active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995004050A1 (en) * | 1993-07-28 | 1995-02-09 | Santen Pharmaceutical Co., Ltd. | Novel 1,4-di(phenylalkyl)piperazine derivative |
US5736546A (en) * | 1993-07-28 | 1998-04-07 | Santen Pharmaceutical Co., Ltd. | 1,4-(diphenlyalkyl) piperazine derivatives |
CN1042029C (en) * | 1993-07-28 | 1999-02-10 | 参天制药株式会社 | Novel 1,4-di(phenylalkyl)piperazine derivative |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS549269A (en) | Carboxylic acid esters, process for their preparation and insecticides and miticides containing the same as active constituents | |
JPS5583771A (en) | N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt | |
JPS5793977A (en) | Acylaminoquinazoline derivative and its preparation | |
JPS54128588A (en) | Antidepressive drugs consisting mainly of 2-(1-piperazinyl)- 4-phenylquinoline | |
JPS5583774A (en) | N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt | |
JPS57203060A (en) | Piperazine derivative | |
JPS5583772A (en) | N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt | |
JPS565462A (en) | Piperazinylalkoxyindanes and their acid addition salt | |
JPS5583770A (en) | N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt | |
JPS5756425A (en) | Hypotensor | |
JPS56142282A (en) | Penem-3-carboxylic acid derivative and its preparation | |
JPS52116497A (en) | Fused-ring triazolopyrimidine derivatives | |
JPS5569512A (en) | Antispasmodic agent | |
JPS5555178A (en) | Pyran derivative | |
JPS5239674A (en) | Imidazole derivatives and agricultural bactericides therefrom | |
JPS53124267A (en) | 1-alkoxyacyl-3-(3,5-dihalogenophenyl)hydantoin derivatives, their preparation and bactericides for agricultural and horticultural uses containing the same as active agent | |
JPS56125340A (en) | Cyclohexenone derivative | |
JPS56142283A (en) | Penem-3-carboxylic acid derivative and its preparation | |
JPS57116052A (en) | Quinazoline derivative and its preparation | |
JPS532473A (en) | N-3-pyridyl-n#-phenylamidine derivatives, method of preparing same, and fungicides for agriculture and gardening use | |
JPS54103879A (en) | Novel penicillamine | |
JPS5430192A (en) | 2-(4-(2-hydroxyethyl)-1-piperazinylmethyl)-5-phenyloxazoles and their pharmaceutically permissible acid addition salt | |
JPS5780379A (en) | (omega-piperazinylalkoxy)alkylenedioxybenzene and its acid addition salt | |
JPS53111063A (en) | Alpha-phenoxypropionic acid derivatives, their preparation and herbicides | |
JPS57122041A (en) | Phenylclohexane derivative |