JPS5646810A - Blood platelet coagulation inhibitor - Google Patents

Blood platelet coagulation inhibitor

Info

Publication number
JPS5646810A
JPS5646810A JP12361679A JP12361679A JPS5646810A JP S5646810 A JPS5646810 A JP S5646810A JP 12361679 A JP12361679 A JP 12361679A JP 12361679 A JP12361679 A JP 12361679A JP S5646810 A JPS5646810 A JP S5646810A
Authority
JP
Japan
Prior art keywords
formula
preparation
blood platelet
coagulation inhibitor
platelet coagulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12361679A
Other languages
Japanese (ja)
Other versions
JPS6258335B2 (en
Inventor
Takao Nishi
Kazuyuki Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP12361679A priority Critical patent/JPS5646810A/en
Publication of JPS5646810A publication Critical patent/JPS5646810A/en
Publication of JPS6258335B2 publication Critical patent/JPS6258335B2/ja
Granted legal-status Critical Current

Links

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  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:Tetrazolepropoxycarbostyrile derivatives of formula I (R is lower alkyl, cycloalkyl).
EXAMPLE: 6-[3-(1-Methyltetrazole-5-yl)propoxy]carbostyrile.
USE: Blood platelet coagulation inhibitor: they are effective on cerebrovascular diseases, ischemic cardiopathy, diabetes, peripheral thrombosis, etc.
PREPARATION: The dehydrohalogenation between 6-hydroxycarbostyrile of formula II and a tetrazole derivative of formula III is effected to give the compound of formula I. The compound of formula I is added to a drug preparation by 1W500mg as an effective component to provide a blood platelet coagulation inhibitor in a form of oral preparation such as tablet, capsule or granule, or injectable or suppository preparation. The resultant preparation keeps the activity for a long period of time and shows very low toxicity, e.g., the side-effect of pulse increase. The dose is suitably 0.06W10mg/kg a day.
COPYRIGHT: (C)1981,JPO&Japio
JP12361679A 1979-09-25 1979-09-25 Blood platelet coagulation inhibitor Granted JPS5646810A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12361679A JPS5646810A (en) 1979-09-25 1979-09-25 Blood platelet coagulation inhibitor

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12361679A JPS5646810A (en) 1979-09-25 1979-09-25 Blood platelet coagulation inhibitor

Publications (2)

Publication Number Publication Date
JPS5646810A true JPS5646810A (en) 1981-04-28
JPS6258335B2 JPS6258335B2 (en) 1987-12-05

Family

ID=14864995

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12361679A Granted JPS5646810A (en) 1979-09-25 1979-09-25 Blood platelet coagulation inhibitor

Country Status (1)

Country Link
JP (1) JPS5646810A (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5859980A (en) * 1981-10-05 1983-04-09 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS6345220A (en) * 1986-04-02 1988-02-26 Otsuka Pharmaceut Co Ltd Platelet adhesion suppresser
JPH02178226A (en) * 1988-12-28 1990-07-11 Otsuka Pharmaceut Co Ltd Remedy for disease accompanying raynaud's phenomenon
WO1991010419A1 (en) * 1990-01-08 1991-07-25 Otsuka Pharmaceutical Co., Ltd. Hair tonic and dressing composition
US6630590B1 (en) * 1999-11-24 2003-10-07 Otsuka Pharmaceutical Co., Ltd. Process for producing carbostyril derivatives
KR20030083108A (en) * 2002-04-19 2003-10-30 오츠카 세이야쿠 가부시키가이샤 Active Oxygen Scavenger
US7026486B2 (en) 2002-09-10 2006-04-11 Otsuka Pharmaceutical Co., Ltd. Process for production cilostazol
US7399864B2 (en) * 2001-05-02 2008-07-15 Otsuka Pharmaceutical Co., Ltd. Process for producing carbostyril derivatives
US7825251B2 (en) 2001-05-02 2010-11-02 Otsuka Pharmaceutical Co., Ltd. Process for producing carbostyril derivatives

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0632323U (en) * 1992-09-29 1994-04-26 凸版印刷株式会社 Spout plug

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5859980A (en) * 1981-10-05 1983-04-09 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS64397B2 (en) * 1981-10-05 1989-01-06 Otsuka Pharma Co Ltd
JPS6345220A (en) * 1986-04-02 1988-02-26 Otsuka Pharmaceut Co Ltd Platelet adhesion suppresser
JPH02178226A (en) * 1988-12-28 1990-07-11 Otsuka Pharmaceut Co Ltd Remedy for disease accompanying raynaud's phenomenon
WO1991010419A1 (en) * 1990-01-08 1991-07-25 Otsuka Pharmaceutical Co., Ltd. Hair tonic and dressing composition
EP0463173B1 (en) * 1990-01-08 1994-12-07 Otsuka Pharmaceutical Co., Ltd. Hair tonic and dressing composition
US6630590B1 (en) * 1999-11-24 2003-10-07 Otsuka Pharmaceutical Co., Ltd. Process for producing carbostyril derivatives
US7399864B2 (en) * 2001-05-02 2008-07-15 Otsuka Pharmaceutical Co., Ltd. Process for producing carbostyril derivatives
US7825251B2 (en) 2001-05-02 2010-11-02 Otsuka Pharmaceutical Co., Ltd. Process for producing carbostyril derivatives
KR20030083108A (en) * 2002-04-19 2003-10-30 오츠카 세이야쿠 가부시키가이샤 Active Oxygen Scavenger
US7026486B2 (en) 2002-09-10 2006-04-11 Otsuka Pharmaceutical Co., Ltd. Process for production cilostazol

Also Published As

Publication number Publication date
JPS6258335B2 (en) 1987-12-05

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