JPS5646810A - Blood platelet coagulation inhibitor - Google Patents
Blood platelet coagulation inhibitorInfo
- Publication number
- JPS5646810A JPS5646810A JP12361679A JP12361679A JPS5646810A JP S5646810 A JPS5646810 A JP S5646810A JP 12361679 A JP12361679 A JP 12361679A JP 12361679 A JP12361679 A JP 12361679A JP S5646810 A JPS5646810 A JP S5646810A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- preparation
- blood platelet
- coagulation inhibitor
- platelet coagulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:Tetrazolepropoxycarbostyrile derivatives of formula I (R is lower alkyl, cycloalkyl).
EXAMPLE: 6-[3-(1-Methyltetrazole-5-yl)propoxy]carbostyrile.
USE: Blood platelet coagulation inhibitor: they are effective on cerebrovascular diseases, ischemic cardiopathy, diabetes, peripheral thrombosis, etc.
PREPARATION: The dehydrohalogenation between 6-hydroxycarbostyrile of formula II and a tetrazole derivative of formula III is effected to give the compound of formula I. The compound of formula I is added to a drug preparation by 1W500mg as an effective component to provide a blood platelet coagulation inhibitor in a form of oral preparation such as tablet, capsule or granule, or injectable or suppository preparation. The resultant preparation keeps the activity for a long period of time and shows very low toxicity, e.g., the side-effect of pulse increase. The dose is suitably 0.06W10mg/kg a day.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12361679A JPS5646810A (en) | 1979-09-25 | 1979-09-25 | Blood platelet coagulation inhibitor |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12361679A JPS5646810A (en) | 1979-09-25 | 1979-09-25 | Blood platelet coagulation inhibitor |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5646810A true JPS5646810A (en) | 1981-04-28 |
JPS6258335B2 JPS6258335B2 (en) | 1987-12-05 |
Family
ID=14864995
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12361679A Granted JPS5646810A (en) | 1979-09-25 | 1979-09-25 | Blood platelet coagulation inhibitor |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5646810A (en) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5859980A (en) * | 1981-10-05 | 1983-04-09 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
JPS6345220A (en) * | 1986-04-02 | 1988-02-26 | Otsuka Pharmaceut Co Ltd | Platelet adhesion suppresser |
JPH02178226A (en) * | 1988-12-28 | 1990-07-11 | Otsuka Pharmaceut Co Ltd | Remedy for disease accompanying raynaud's phenomenon |
WO1991010419A1 (en) * | 1990-01-08 | 1991-07-25 | Otsuka Pharmaceutical Co., Ltd. | Hair tonic and dressing composition |
US6630590B1 (en) * | 1999-11-24 | 2003-10-07 | Otsuka Pharmaceutical Co., Ltd. | Process for producing carbostyril derivatives |
KR20030083108A (en) * | 2002-04-19 | 2003-10-30 | 오츠카 세이야쿠 가부시키가이샤 | Active Oxygen Scavenger |
US7026486B2 (en) | 2002-09-10 | 2006-04-11 | Otsuka Pharmaceutical Co., Ltd. | Process for production cilostazol |
US7399864B2 (en) * | 2001-05-02 | 2008-07-15 | Otsuka Pharmaceutical Co., Ltd. | Process for producing carbostyril derivatives |
US7825251B2 (en) | 2001-05-02 | 2010-11-02 | Otsuka Pharmaceutical Co., Ltd. | Process for producing carbostyril derivatives |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0632323U (en) * | 1992-09-29 | 1994-04-26 | 凸版印刷株式会社 | Spout plug |
-
1979
- 1979-09-25 JP JP12361679A patent/JPS5646810A/en active Granted
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5859980A (en) * | 1981-10-05 | 1983-04-09 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
JPS64397B2 (en) * | 1981-10-05 | 1989-01-06 | Otsuka Pharma Co Ltd | |
JPS6345220A (en) * | 1986-04-02 | 1988-02-26 | Otsuka Pharmaceut Co Ltd | Platelet adhesion suppresser |
JPH02178226A (en) * | 1988-12-28 | 1990-07-11 | Otsuka Pharmaceut Co Ltd | Remedy for disease accompanying raynaud's phenomenon |
WO1991010419A1 (en) * | 1990-01-08 | 1991-07-25 | Otsuka Pharmaceutical Co., Ltd. | Hair tonic and dressing composition |
EP0463173B1 (en) * | 1990-01-08 | 1994-12-07 | Otsuka Pharmaceutical Co., Ltd. | Hair tonic and dressing composition |
US6630590B1 (en) * | 1999-11-24 | 2003-10-07 | Otsuka Pharmaceutical Co., Ltd. | Process for producing carbostyril derivatives |
US7399864B2 (en) * | 2001-05-02 | 2008-07-15 | Otsuka Pharmaceutical Co., Ltd. | Process for producing carbostyril derivatives |
US7825251B2 (en) | 2001-05-02 | 2010-11-02 | Otsuka Pharmaceutical Co., Ltd. | Process for producing carbostyril derivatives |
KR20030083108A (en) * | 2002-04-19 | 2003-10-30 | 오츠카 세이야쿠 가부시키가이샤 | Active Oxygen Scavenger |
US7026486B2 (en) | 2002-09-10 | 2006-04-11 | Otsuka Pharmaceutical Co., Ltd. | Process for production cilostazol |
Also Published As
Publication number | Publication date |
---|---|
JPS6258335B2 (en) | 1987-12-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL53832A (en) | Haloalkenylcyclopropane carboxylic acid and derivatives thereof,their preparation and insecticidal and acaricidal compositions containing some of these compounds | |
JPS5412372A (en) | Thiazolidine derivative and its preparation | |
JPS5646810A (en) | Blood platelet coagulation inhibitor | |
JPS5283380A (en) | Synthesis of thiocarbostyril derivatives | |
JPS5630917A (en) | Preventive and remedy for hepatitis | |
ES481855A1 (en) | 6-Methoxy-2-acethylnaphthalene oximes | |
JPS5695188A (en) | Theophyllin derivative and its production | |
JPS5436282A (en) | Preparation of substituted piperazine | |
JPS5495716A (en) | Remedy for mycobacteriosis | |
JPS57126419A (en) | Analgesic agent | |
JPS54135231A (en) | Cardio-vasocular medicine | |
JPS527962A (en) | Preparation of (1-aryl-4,5,6,7- tetrahydro-1h-indazol-3-yloxy) alkanoi c acids | |
JPS5594317A (en) | Antifungal agent | |
ES465872A1 (en) | 1-phenoxy-3-t-butylaminopropan-2-ols | |
JPS5671087A (en) | Courmarine derivative, its preparation, and antiallergic agent containing the same as the effective component | |
JPS5337637A (en) | Preparation of phenylmalonic acid diester derivatives | |
JPS5276431A (en) | Herbicidal composition for paddy fields | |
JPS5242892A (en) | Preparation of 1beta h, 13alpha h-9-oxabicyclo 11,3,0 hexadeca-3-ene derivative s | |
ES8103774A1 (en) | New triazene compound, process for the preparation thereof, and pharmaceutical composition comprising the same. | |
JPS57108017A (en) | Antithrombotic agent | |
JPS5420141A (en) | Method and composition for preventing gastro-intestinal diseases of cattle | |
JPS5251032A (en) | Medicines of disaccharide-glutathione derivatives | |
JPS525798A (en) | Preparation of pyridopyridazine derivatives | |
CROCKETT | Toxicity of vinyl chloride. A bibliography with abstracts[Progress Report, 1969- Apr. 1978] | |
JPS5246049A (en) | Process for preparation of 2-methyl-3-alkyl-2-cyclopentene-1,4-dione |