JPS57144266A - 4-anilinoquinazoline derivative, its preparation, and analgesic and antiphlogistic agent containing said derivative as active component - Google Patents

4-anilinoquinazoline derivative, its preparation, and analgesic and antiphlogistic agent containing said derivative as active component

Info

Publication number
JPS57144266A
JPS57144266A JP3081681A JP3081681A JPS57144266A JP S57144266 A JPS57144266 A JP S57144266A JP 3081681 A JP3081681 A JP 3081681A JP 3081681 A JP3081681 A JP 3081681A JP S57144266 A JPS57144266 A JP S57144266A
Authority
JP
Japan
Prior art keywords
derivative
analgesic
preparation
active component
agent containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP3081681A
Other languages
Japanese (ja)
Inventor
Shinsaku Kobayashi
Katsuo Kamoshita
Takeo Honda
Katsutoshi Fujii
Mikio Kojima
Takashi Furubayashi
Tokio Obata
Yuuji Akiyoshi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Ube Corp
Original Assignee
Sankyo Co Ltd
Ube Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd, Ube Industries Ltd filed Critical Sankyo Co Ltd
Priority to JP3081681A priority Critical patent/JPS57144266A/en
Publication of JPS57144266A publication Critical patent/JPS57144266A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:The compound of formulaI(R1 is H or lower alkyl; R2 is H, lower alkyl, lower alkoxy, lower alkylthio, CF3 or halogen; n is 1 or 2; when n is 2, R2 may be methylenedioxy) and its acid addition salt.
EXAMPLE: 4-(4-Methoxyanilino)-6-fluoroquinazoline.
USE: Analgesic and antiphlogistic agent.
PROCESS: The compound of formulaIcan be prepared by refluxing the 4-halogenoquinazoline derivative of formula II (X is halogen) and the aniline derivative of formula III in a solvent at the boiling point of the solvent for 5minW5hr.
COPYRIGHT: (C)1982,JPO&Japio
JP3081681A 1981-03-04 1981-03-04 4-anilinoquinazoline derivative, its preparation, and analgesic and antiphlogistic agent containing said derivative as active component Pending JPS57144266A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3081681A JPS57144266A (en) 1981-03-04 1981-03-04 4-anilinoquinazoline derivative, its preparation, and analgesic and antiphlogistic agent containing said derivative as active component

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3081681A JPS57144266A (en) 1981-03-04 1981-03-04 4-anilinoquinazoline derivative, its preparation, and analgesic and antiphlogistic agent containing said derivative as active component

Publications (1)

Publication Number Publication Date
JPS57144266A true JPS57144266A (en) 1982-09-06

Family

ID=12314215

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3081681A Pending JPS57144266A (en) 1981-03-04 1981-03-04 4-anilinoquinazoline derivative, its preparation, and analgesic and antiphlogistic agent containing said derivative as active component

Country Status (1)

Country Link
JP (1) JPS57144266A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2049659A1 (en) * 1992-10-08 1994-04-16 Ici Plc Pharmaceutical compsn. comprising quinazoline derivs. - inhibit receptor tyrosine kinase(s) and are used for treating cancers e.g. leukaemia(s) and tumours of breast, lung, colon, rectum, etc.
EP0635498A1 (en) * 1993-07-19 1995-01-25 Zeneca Limited Quinazoline derivatives and their use as anti-cancer agents
WO2000072849A1 (en) * 1999-06-01 2000-12-07 Hadasit Medical Research Services And Development Ltd. Novel epidermal growth factor receptor-binding compounds for positron emission tomography
US8309562B2 (en) * 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
US10710968B2 (en) 2016-01-13 2020-07-14 Hadasit Medical Research Services And Development Ltd. Radiolabeled erlotinib analogs and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5538325A (en) * 1978-09-11 1980-03-17 Sankyo Co Ltd 4-anilinoquinazoline derivative and its preparation
JPS5620577A (en) * 1979-07-27 1981-02-26 Sankyo Co Ltd 4- n-alkylanilino quinazoline derivative and its preparation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5538325A (en) * 1978-09-11 1980-03-17 Sankyo Co Ltd 4-anilinoquinazoline derivative and its preparation
JPS5620577A (en) * 1979-07-27 1981-02-26 Sankyo Co Ltd 4- n-alkylanilino quinazoline derivative and its preparation

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2049659A1 (en) * 1992-10-08 1994-04-16 Ici Plc Pharmaceutical compsn. comprising quinazoline derivs. - inhibit receptor tyrosine kinase(s) and are used for treating cancers e.g. leukaemia(s) and tumours of breast, lung, colon, rectum, etc.
EP0635498A1 (en) * 1993-07-19 1995-01-25 Zeneca Limited Quinazoline derivatives and their use as anti-cancer agents
WO1995003283A1 (en) * 1993-07-19 1995-02-02 Zeneca Limited Quinazoline derivatives and their use as anti-cancer agents
WO2000072849A1 (en) * 1999-06-01 2000-12-07 Hadasit Medical Research Services And Development Ltd. Novel epidermal growth factor receptor-binding compounds for positron emission tomography
US8309562B2 (en) * 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
US10710968B2 (en) 2016-01-13 2020-07-14 Hadasit Medical Research Services And Development Ltd. Radiolabeled erlotinib analogs and uses thereof

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