JPS57144266A - 4-anilinoquinazoline derivative, its preparation, and analgesic and antiphlogistic agent containing said derivative as active component - Google Patents
4-anilinoquinazoline derivative, its preparation, and analgesic and antiphlogistic agent containing said derivative as active componentInfo
- Publication number
- JPS57144266A JPS57144266A JP3081681A JP3081681A JPS57144266A JP S57144266 A JPS57144266 A JP S57144266A JP 3081681 A JP3081681 A JP 3081681A JP 3081681 A JP3081681 A JP 3081681A JP S57144266 A JPS57144266 A JP S57144266A
- Authority
- JP
- Japan
- Prior art keywords
- derivative
- analgesic
- preparation
- active component
- agent containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:The compound of formulaI(R1 is H or lower alkyl; R2 is H, lower alkyl, lower alkoxy, lower alkylthio, CF3 or halogen; n is 1 or 2; when n is 2, R2 may be methylenedioxy) and its acid addition salt.
EXAMPLE: 4-(4-Methoxyanilino)-6-fluoroquinazoline.
USE: Analgesic and antiphlogistic agent.
PROCESS: The compound of formulaIcan be prepared by refluxing the 4-halogenoquinazoline derivative of formula II (X is halogen) and the aniline derivative of formula III in a solvent at the boiling point of the solvent for 5minW5hr.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3081681A JPS57144266A (en) | 1981-03-04 | 1981-03-04 | 4-anilinoquinazoline derivative, its preparation, and analgesic and antiphlogistic agent containing said derivative as active component |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3081681A JPS57144266A (en) | 1981-03-04 | 1981-03-04 | 4-anilinoquinazoline derivative, its preparation, and analgesic and antiphlogistic agent containing said derivative as active component |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57144266A true JPS57144266A (en) | 1982-09-06 |
Family
ID=12314215
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3081681A Pending JPS57144266A (en) | 1981-03-04 | 1981-03-04 | 4-anilinoquinazoline derivative, its preparation, and analgesic and antiphlogistic agent containing said derivative as active component |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57144266A (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2049659A1 (en) * | 1992-10-08 | 1994-04-16 | Ici Plc | Pharmaceutical compsn. comprising quinazoline derivs. - inhibit receptor tyrosine kinase(s) and are used for treating cancers e.g. leukaemia(s) and tumours of breast, lung, colon, rectum, etc. |
EP0635498A1 (en) * | 1993-07-19 | 1995-01-25 | Zeneca Limited | Quinazoline derivatives and their use as anti-cancer agents |
WO2000072849A1 (en) * | 1999-06-01 | 2000-12-07 | Hadasit Medical Research Services And Development Ltd. | Novel epidermal growth factor receptor-binding compounds for positron emission tomography |
US8309562B2 (en) * | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
US10710968B2 (en) | 2016-01-13 | 2020-07-14 | Hadasit Medical Research Services And Development Ltd. | Radiolabeled erlotinib analogs and uses thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5538325A (en) * | 1978-09-11 | 1980-03-17 | Sankyo Co Ltd | 4-anilinoquinazoline derivative and its preparation |
JPS5620577A (en) * | 1979-07-27 | 1981-02-26 | Sankyo Co Ltd | 4- n-alkylanilino quinazoline derivative and its preparation |
-
1981
- 1981-03-04 JP JP3081681A patent/JPS57144266A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5538325A (en) * | 1978-09-11 | 1980-03-17 | Sankyo Co Ltd | 4-anilinoquinazoline derivative and its preparation |
JPS5620577A (en) * | 1979-07-27 | 1981-02-26 | Sankyo Co Ltd | 4- n-alkylanilino quinazoline derivative and its preparation |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2049659A1 (en) * | 1992-10-08 | 1994-04-16 | Ici Plc | Pharmaceutical compsn. comprising quinazoline derivs. - inhibit receptor tyrosine kinase(s) and are used for treating cancers e.g. leukaemia(s) and tumours of breast, lung, colon, rectum, etc. |
EP0635498A1 (en) * | 1993-07-19 | 1995-01-25 | Zeneca Limited | Quinazoline derivatives and their use as anti-cancer agents |
WO1995003283A1 (en) * | 1993-07-19 | 1995-02-02 | Zeneca Limited | Quinazoline derivatives and their use as anti-cancer agents |
WO2000072849A1 (en) * | 1999-06-01 | 2000-12-07 | Hadasit Medical Research Services And Development Ltd. | Novel epidermal growth factor receptor-binding compounds for positron emission tomography |
US8309562B2 (en) * | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
US10710968B2 (en) | 2016-01-13 | 2020-07-14 | Hadasit Medical Research Services And Development Ltd. | Radiolabeled erlotinib analogs and uses thereof |
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