JPS5714585A - 1-cycloalkylmethylpiperazine derivative - Google Patents
1-cycloalkylmethylpiperazine derivativeInfo
- Publication number
- JPS5714585A JPS5714585A JP8978280A JP8978280A JPS5714585A JP S5714585 A JPS5714585 A JP S5714585A JP 8978280 A JP8978280 A JP 8978280A JP 8978280 A JP8978280 A JP 8978280A JP S5714585 A JPS5714585 A JP S5714585A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- expressed
- derivative
- cycloalkylmethylpiperazine
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A 1-cycloalkylmethylpiperazine derivative expressed by formula I [R is phenyl having a substituent group (halogen, CF3, lower alkyl, lower alkoxl or OH); n is an integer 1-4] and a salt thereof.
EXAMPLE: 1-(Cyclopropylmethyl)-4-(4-fluorophenyl) piperazine dihydrochloride.
USE: An analgesic agent.
PROCESS: A halide expressed by formula 2 (X is halogen) is reacted with a piperazine derivative expressed by formula III, preferably in the presence of a basic compound, in a solvent to give the compound expressed by formula I. Alternatively, an acylpiperazine derivative expressed by formula IV is reduced with lithium aluminum hydride, preferably in a solvent, to give the compound expressed by formula I.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8978280A JPS5714585A (en) | 1980-06-30 | 1980-06-30 | 1-cycloalkylmethylpiperazine derivative |
US06/275,690 US4518712A (en) | 1980-06-30 | 1981-06-22 | Piperazine derivative and analgesic composition containing the same |
AU72310/81A AU524157B2 (en) | 1980-06-30 | 1981-06-26 | Piperazine derivative |
KR1019810002315A KR850000216B1 (en) | 1980-06-30 | 1981-06-26 | Process for preparing piperazine derivatives |
IT48772/81A IT1171335B (en) | 1980-06-30 | 1981-06-26 | PIPERAZINE DERIVATIVE PROCEDURE TO PREPARE IT AND ANALGESIC COMPOSITION CONTAINING IT |
CH4230/81A CH649995A5 (en) | 1980-06-30 | 1981-06-26 | PIPERAZINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS. |
NL8103131A NL191307C (en) | 1980-06-30 | 1981-06-29 | Analgesically active piperazine derivatives and pharmaceutical preparations containing these derivatives. |
ES503502A ES503502A0 (en) | 1980-06-30 | 1981-06-29 | A PROCEDURE FOR THE PRODUCTION OF A DERIVATIVE OF PRIPE-RAZINA. |
CA000380805A CA1203239A (en) | 1980-06-30 | 1981-06-29 | Piperazine derivative, process for preparation thereof and analgesic composition containing the same |
DE3125471A DE3125471C2 (en) | 1980-06-30 | 1981-06-29 | Piperazine derivatives, processes for their preparation and pharmaceuticals containing these compounds |
FR8112742A FR2493315A1 (en) | 1980-06-30 | 1981-06-29 | PIPERAZINE DERIVATIVE, PROCESS FOR PREPARATION AND ANALGESIC COMPOSITION CONTAINING THE SAME |
GB8119960A GB2078746B (en) | 1980-06-30 | 1981-06-29 | Piperazine derivatives for use as analgesics |
ES512562A ES512562A0 (en) | 1980-06-30 | 1982-05-26 | A PROCEDURE FOR THE PRODUCTION OF A PIPERAZINE DERIVATIVE. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8978280A JPS5714585A (en) | 1980-06-30 | 1980-06-30 | 1-cycloalkylmethylpiperazine derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5714585A true JPS5714585A (en) | 1982-01-25 |
JPS6342625B2 JPS6342625B2 (en) | 1988-08-24 |
Family
ID=13980245
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8978280A Granted JPS5714585A (en) | 1980-06-30 | 1980-06-30 | 1-cycloalkylmethylpiperazine derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5714585A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63501994A (en) * | 1985-12-20 | 1988-08-04 | ヒユ−ズ・エアクラフト・カンパニ− | laser resonator |
JP2003518096A (en) * | 1999-12-22 | 2003-06-03 | アー カールッスン リサーチ アーベー | Novel modulators of dopamine neurotransmission |
-
1980
- 1980-06-30 JP JP8978280A patent/JPS5714585A/en active Granted
Non-Patent Citations (1)
Title |
---|
CHEMICAL ABSTRACTS * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63501994A (en) * | 1985-12-20 | 1988-08-04 | ヒユ−ズ・エアクラフト・カンパニ− | laser resonator |
JP2003518096A (en) * | 1999-12-22 | 2003-06-03 | アー カールッスン リサーチ アーベー | Novel modulators of dopamine neurotransmission |
Also Published As
Publication number | Publication date |
---|---|
JPS6342625B2 (en) | 1988-08-24 |
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