JPS5714585A - 1-cycloalkylmethylpiperazine derivative - Google Patents

1-cycloalkylmethylpiperazine derivative

Info

Publication number
JPS5714585A
JPS5714585A JP8978280A JP8978280A JPS5714585A JP S5714585 A JPS5714585 A JP S5714585A JP 8978280 A JP8978280 A JP 8978280A JP 8978280 A JP8978280 A JP 8978280A JP S5714585 A JPS5714585 A JP S5714585A
Authority
JP
Japan
Prior art keywords
formula
expressed
derivative
cycloalkylmethylpiperazine
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP8978280A
Other languages
Japanese (ja)
Other versions
JPS6342625B2 (en
Inventor
Hajime Fujimura
Yasuzo Hiramatsu
Tomio Yamazaki
Shozo Yamada
Takatsugu Honna
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taiho Pharmaceutical Co Ltd
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Priority to JP8978280A priority Critical patent/JPS5714585A/en
Priority to US06/275,690 priority patent/US4518712A/en
Priority to AU72310/81A priority patent/AU524157B2/en
Priority to KR1019810002315A priority patent/KR850000216B1/en
Priority to IT48772/81A priority patent/IT1171335B/en
Priority to CH4230/81A priority patent/CH649995A5/en
Priority to ES503502A priority patent/ES503502A0/en
Priority to NL8103131A priority patent/NL191307C/en
Priority to CA000380805A priority patent/CA1203239A/en
Priority to DE3125471A priority patent/DE3125471C2/en
Priority to FR8112742A priority patent/FR2493315A1/en
Priority to GB8119960A priority patent/GB2078746B/en
Publication of JPS5714585A publication Critical patent/JPS5714585A/en
Priority to ES512562A priority patent/ES512562A0/en
Publication of JPS6342625B2 publication Critical patent/JPS6342625B2/ja
Granted legal-status Critical Current

Links

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A 1-cycloalkylmethylpiperazine derivative expressed by formula I [R is phenyl having a substituent group (halogen, CF3, lower alkyl, lower alkoxl or OH); n is an integer 1-4] and a salt thereof.
EXAMPLE: 1-(Cyclopropylmethyl)-4-(4-fluorophenyl) piperazine dihydrochloride.
USE: An analgesic agent.
PROCESS: A halide expressed by formula 2 (X is halogen) is reacted with a piperazine derivative expressed by formula III, preferably in the presence of a basic compound, in a solvent to give the compound expressed by formula I. Alternatively, an acylpiperazine derivative expressed by formula IV is reduced with lithium aluminum hydride, preferably in a solvent, to give the compound expressed by formula I.
COPYRIGHT: (C)1982,JPO&Japio
JP8978280A 1980-06-30 1980-06-30 1-cycloalkylmethylpiperazine derivative Granted JPS5714585A (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
JP8978280A JPS5714585A (en) 1980-06-30 1980-06-30 1-cycloalkylmethylpiperazine derivative
US06/275,690 US4518712A (en) 1980-06-30 1981-06-22 Piperazine derivative and analgesic composition containing the same
AU72310/81A AU524157B2 (en) 1980-06-30 1981-06-26 Piperazine derivative
KR1019810002315A KR850000216B1 (en) 1980-06-30 1981-06-26 Process for preparing piperazine derivatives
IT48772/81A IT1171335B (en) 1980-06-30 1981-06-26 PIPERAZINE DERIVATIVE PROCEDURE TO PREPARE IT AND ANALGESIC COMPOSITION CONTAINING IT
CH4230/81A CH649995A5 (en) 1980-06-30 1981-06-26 PIPERAZINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS.
NL8103131A NL191307C (en) 1980-06-30 1981-06-29 Analgesically active piperazine derivatives and pharmaceutical preparations containing these derivatives.
ES503502A ES503502A0 (en) 1980-06-30 1981-06-29 A PROCEDURE FOR THE PRODUCTION OF A DERIVATIVE OF PRIPE-RAZINA.
CA000380805A CA1203239A (en) 1980-06-30 1981-06-29 Piperazine derivative, process for preparation thereof and analgesic composition containing the same
DE3125471A DE3125471C2 (en) 1980-06-30 1981-06-29 Piperazine derivatives, processes for their preparation and pharmaceuticals containing these compounds
FR8112742A FR2493315A1 (en) 1980-06-30 1981-06-29 PIPERAZINE DERIVATIVE, PROCESS FOR PREPARATION AND ANALGESIC COMPOSITION CONTAINING THE SAME
GB8119960A GB2078746B (en) 1980-06-30 1981-06-29 Piperazine derivatives for use as analgesics
ES512562A ES512562A0 (en) 1980-06-30 1982-05-26 A PROCEDURE FOR THE PRODUCTION OF A PIPERAZINE DERIVATIVE.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8978280A JPS5714585A (en) 1980-06-30 1980-06-30 1-cycloalkylmethylpiperazine derivative

Publications (2)

Publication Number Publication Date
JPS5714585A true JPS5714585A (en) 1982-01-25
JPS6342625B2 JPS6342625B2 (en) 1988-08-24

Family

ID=13980245

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8978280A Granted JPS5714585A (en) 1980-06-30 1980-06-30 1-cycloalkylmethylpiperazine derivative

Country Status (1)

Country Link
JP (1) JPS5714585A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63501994A (en) * 1985-12-20 1988-08-04 ヒユ−ズ・エアクラフト・カンパニ− laser resonator
JP2003518096A (en) * 1999-12-22 2003-06-03 アー カールッスン リサーチ アーベー Novel modulators of dopamine neurotransmission

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63501994A (en) * 1985-12-20 1988-08-04 ヒユ−ズ・エアクラフト・カンパニ− laser resonator
JP2003518096A (en) * 1999-12-22 2003-06-03 アー カールッスン リサーチ アーベー Novel modulators of dopamine neurotransmission

Also Published As

Publication number Publication date
JPS6342625B2 (en) 1988-08-24

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