JPS52113979A - Novel 3,4-dihydrocarbostyril derivatives and method preparing the same - Google Patents

Novel 3,4-dihydrocarbostyril derivatives and method preparing the same

Info

Publication number
JPS52113979A
JPS52113979A JP2895776A JP2895776A JPS52113979A JP S52113979 A JPS52113979 A JP S52113979A JP 2895776 A JP2895776 A JP 2895776A JP 2895776 A JP2895776 A JP 2895776A JP S52113979 A JPS52113979 A JP S52113979A
Authority
JP
Japan
Prior art keywords
novel
same
method preparing
dihydrocarbostyril derivatives
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2895776A
Other languages
Japanese (ja)
Other versions
JPS5919541B2 (en
Inventor
Michiaki Tominaga
Hitoshi Tone
Kazuyuki Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP51028957A priority Critical patent/JPS5919541B2/en
Priority to ZA00771461A priority patent/ZA771461B/en
Priority to CH308777A priority patent/CH619453A5/fr
Priority to FI770827A priority patent/FI63224C/en
Priority to IE378/82A priority patent/IE45270B1/en
Priority to IE563/77A priority patent/IE45269B1/en
Priority to NO770940A priority patent/NO149388C/en
Priority to LU76957A priority patent/LU76957A1/xx
Priority to MX775546U priority patent/MX4808E/en
Priority to AU23299/77A priority patent/AU513950B2/en
Priority to DK115677A priority patent/DK154970C/en
Priority to SE7703000A priority patent/SE443140B/en
Priority to PT66312A priority patent/PT66312B/en
Priority to DE2711719A priority patent/DE2711719C2/en
Priority to PH19562A priority patent/PH15115A/en
Priority to BE175856A priority patent/BE852556A/en
Priority to GB11461/77A priority patent/GB1578971A/en
Priority to NLAANVRAGE7702896,A priority patent/NL179816C/en
Priority to GB27038/79A priority patent/GB1578972A/en
Priority to AR266891A priority patent/AR211570A1/en
Priority to CA274,453A priority patent/CA1081232A/en
Priority to AT0181577A priority patent/AT363474B/en
Priority to ES456963A priority patent/ES456963A1/en
Priority to FR7708041A priority patent/FR2344538A1/en
Publication of JPS52113979A publication Critical patent/JPS52113979A/en
Priority to US05/965,469 priority patent/US4302588A/en
Priority to US05/965,535 priority patent/US4289883A/en
Priority to US05/965,470 priority patent/US4210753A/en
Publication of JPS5919541B2 publication Critical patent/JPS5919541B2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C07D215/32—Esters

Abstract

PURPOSE: Title compounds of formula I (R1 is H, lower alkyl, aralkyl; R3 is H, lower alkyl, aralkyl, with the proviso that when R3 is lower alkyl R1 is not H) and acid addition salts thereof; for example, 1-methyl-5-(3-benzylamino-2-hydroxypropoxy)-8-benzyloxy-3,4-dihydrocarboxtyril hydrochloride.
COPYRIGHT: (C)1977,JPO&Japio
JP51028957A 1976-03-17 1976-03-17 New 3,4-dihydrocarbostyryl derivative Expired JPS5919541B2 (en)

Priority Applications (27)

Application Number Priority Date Filing Date Title
JP51028957A JPS5919541B2 (en) 1976-03-17 1976-03-17 New 3,4-dihydrocarbostyryl derivative
ZA00771461A ZA771461B (en) 1976-03-17 1977-03-10 Carbostyril derivatives and process for preparing the same
CH308777A CH619453A5 (en) 1976-03-17 1977-03-11
FI770827A FI63224C (en) 1976-03-17 1977-03-15 FRUIT PROCESSING FOR MEDICAL ANALYSIS OF 5- (3-AMINO-2-HYDROXIPROPOXI) -CARBOSTYRILDERIVAT
IE378/82A IE45270B1 (en) 1976-03-17 1977-03-15 8-hydroxy-5-propoxy carbostyrils
IE563/77A IE45269B1 (en) 1976-03-17 1977-03-15 8-hydroxy-5-(3-amino-2-hydroxypropoxy) carbostyrils and derivatives thereof
NO770940A NO149388C (en) 1976-03-17 1977-03-16 ANALOGY PROCEDURE FOR THE PREPARATION OF PHARMACOLOGICALLY ACTIVE CARBOSTYRIL DERIVATIVES
LU76957A LU76957A1 (en) 1976-03-17 1977-03-16
MX775546U MX4808E (en) 1976-03-17 1977-03-16 AN IMPROVED PROCESS FOR PREPARING CARBOSTIRILE DERIVATIVES
AU23299/77A AU513950B2 (en) 1976-03-17 1977-03-16 Carbostyril derivatives
DK115677A DK154970C (en) 1976-03-17 1977-03-16 ANALOGY PROCEDURE FOR THE PREPARATION OF CARBOSTYRIC DERIVATIVES
SE7703000A SE443140B (en) 1976-03-17 1977-03-16 PROCEDURE FOR PREPARING CARBOSTYRIC DERIVATIVES
PT66312A PT66312B (en) 1976-03-17 1977-03-16 Process for preparing carbostyril derivatives
DE2711719A DE2711719C2 (en) 1976-03-17 1977-03-17 3,4-Dihydrocarbostyril derivatives, processes for their preparation and pharmaceuticals containing them
ES456963A ES456963A1 (en) 1976-03-17 1977-03-17 Carbostyril compounds
BE175856A BE852556A (en) 1976-03-17 1977-03-17 CARBOSTYRILE DERIVATIVES AND THEIR PREPARATION PROCESS
GB11461/77A GB1578971A (en) 1976-03-17 1977-03-17 8-hydroxy-5-(3-amino-2-hydroxypropoxy) carbostyrils and derivatives thereof
NLAANVRAGE7702896,A NL179816C (en) 1976-03-17 1977-03-17 PROCESS FOR THE PREPARATION OF A PHARMACEUTICAL PREPARATION WITH A BETA-BLOCKING ACTIVITY, PHARMACEUTICAL ARTICLES MANUFACTURED AND PROCESS FOR THE PREPARATION OF NEW 5- (2-HYDROXY-3-SUBSTRUCTIUS-PROBYSTHYL-PROSTURBED-AMINO-CARBO) SALTS THEREOF.
GB27038/79A GB1578972A (en) 1976-03-17 1977-03-17 8-hydroxy-5-propoxy-carbostyrils
AR266891A AR211570A1 (en) 1976-03-17 1977-03-17 PROCEDURE FOR THE PREPARATION OF NEW DERIVATIVES OF 8-OXI-5- (2-HYDROXI-3-AMINOPROPOXI) -CARBOSTIRILO
CA274,453A CA1081232A (en) 1976-03-17 1977-03-17 5-(3-substituted-2-hydroxypropoxy)-8-substituted-carbostyril and 3,4-dihydrocarbostyril compounds
AT0181577A AT363474B (en) 1976-03-17 1977-03-17 METHOD FOR PRODUCING NEW CARBOSTYRILE DERIVATIVES AND THEIR PHARMACEUTICAL SUITABLE ACID ADDITION SALTS
PH19562A PH15115A (en) 1976-03-17 1977-03-17 Carbostyril and 3,4 dihydrocarbostyril
FR7708041A FR2344538A1 (en) 1976-03-17 1977-03-17 NEW CARBOSTYRILE DERIVATIVES, USEFUL IN PARTICULAR AS CARDIO-SELECTIVE B-BLOCKERS, AND THEIR PREPARATION PROCESS
US05/965,469 US4302588A (en) 1976-03-17 1978-11-30 Carbostyril compounds
US05/965,535 US4289883A (en) 1976-03-17 1978-11-30 Carbostyril compounds
US05/965,470 US4210753A (en) 1976-03-17 1978-11-30 Carbostyril compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP51028957A JPS5919541B2 (en) 1976-03-17 1976-03-17 New 3,4-dihydrocarbostyryl derivative

Publications (2)

Publication Number Publication Date
JPS52113979A true JPS52113979A (en) 1977-09-24
JPS5919541B2 JPS5919541B2 (en) 1984-05-07

Family

ID=12262885

Family Applications (1)

Application Number Title Priority Date Filing Date
JP51028957A Expired JPS5919541B2 (en) 1976-03-17 1976-03-17 New 3,4-dihydrocarbostyryl derivative

Country Status (3)

Country Link
JP (1) JPS5919541B2 (en)
BE (1) BE852556A (en)
ZA (1) ZA771461B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4482560A (en) * 1979-09-18 1984-11-13 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives, and antihistaminic agents containing the same
JP2006509790A (en) * 2002-11-27 2006-03-23 アルテシアン セラピューティック，インコーポレイティド Compounds with mixed PDE inhibition and beta-adrenergic antagonist activity or partial agonist activity for the treatment of heart failure

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4482560A (en) * 1979-09-18 1984-11-13 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives, and antihistaminic agents containing the same
JP2006509790A (en) * 2002-11-27 2006-03-23 アルテシアン セラピューティック，インコーポレイティド Compounds with mixed PDE inhibition and beta-adrenergic antagonist activity or partial agonist activity for the treatment of heart failure

Also Published As

Publication number Publication date
JPS5919541B2 (en) 1984-05-07
ZA771461B (en) 1978-08-30
BE852556A (en) 1977-07-18

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