JPS5714590A - 2-benzyl-5-alkyl-tetrahydro-benzo(b)-1,6-naphthyridin-10-one derivative and its preparation - Google Patents
2-benzyl-5-alkyl-tetrahydro-benzo(b)-1,6-naphthyridin-10-one derivative and its preparationInfo
- Publication number
- JPS5714590A JPS5714590A JP8918080A JP8918080A JPS5714590A JP S5714590 A JPS5714590 A JP S5714590A JP 8918080 A JP8918080 A JP 8918080A JP 8918080 A JP8918080 A JP 8918080A JP S5714590 A JPS5714590 A JP S5714590A
- Authority
- JP
- Japan
- Prior art keywords
- benzyl
- naphthyridin
- benzo
- alkyl
- tetrahydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 150000008065 acid anhydrides Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000001387 anti-histamine Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- -1 pyridine Chemical class 0.000 abstract 1
Abstract
NEW MATERIAL:A 2-benzyl-5-alkyl-hexahydro-benzo(b)-1,6-naphthyridin-10-one derivative of formula I (R is lower alkyl). EXAMLE:2-Benzyl-5-methyl-1,2,3,4-tetrahydro ( 5H, 10H ) -benzo(b)-1,6-naphthyridin-10-one.
USE: Useful as a medicine having analgesic, anti-inflammatory and antihistaminic action.
PROCESS: A-1-benzyl-1'-alkylspiro [ piperidine-4,2'- ( 1',2',3',4'-tetrahydroquinazolin)]-4'-one is reacted with an acylating agent, e.g. an acid anhydride, in the presence of a deacidifying agent, e.g. an organic amine such as pyridine, at 100W 150°C for several hours to give the compound of formula I.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8918080A JPS5714590A (en) | 1980-07-02 | 1980-07-02 | 2-benzyl-5-alkyl-tetrahydro-benzo(b)-1,6-naphthyridin-10-one derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8918080A JPS5714590A (en) | 1980-07-02 | 1980-07-02 | 2-benzyl-5-alkyl-tetrahydro-benzo(b)-1,6-naphthyridin-10-one derivative and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5714590A true JPS5714590A (en) | 1982-01-25 |
Family
ID=13963554
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8918080A Pending JPS5714590A (en) | 1980-07-02 | 1980-07-02 | 2-benzyl-5-alkyl-tetrahydro-benzo(b)-1,6-naphthyridin-10-one derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5714590A (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4810708A (en) * | 1986-05-15 | 1989-03-07 | Schering Corporation | Polycyclic quinoline, naphthyridine and pyrazinopyridine derivatives |
US4988705A (en) * | 1985-06-13 | 1991-01-29 | Schering Corporation | Polycyclic quinoline, naphthyridine and pyrazinopyridine derivatives |
US5126352A (en) * | 1985-06-13 | 1992-06-30 | Schering Corporation | Polycyclic quinoline, naphthyridine and pyrazinopyridine derivatives |
WO2004035581A1 (en) * | 2002-10-18 | 2004-04-29 | Ono Pharmaceutical Co., Ltd. | Spiroheterocyclic derivative compounds and drugs comprising the compounds as the active ingredient |
EP3375784A1 (en) * | 2017-03-14 | 2018-09-19 | Artax Biopharma Inc. | Aza-dihydro-acridone derivatives |
-
1980
- 1980-07-02 JP JP8918080A patent/JPS5714590A/en active Pending
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4988705A (en) * | 1985-06-13 | 1991-01-29 | Schering Corporation | Polycyclic quinoline, naphthyridine and pyrazinopyridine derivatives |
US5126352A (en) * | 1985-06-13 | 1992-06-30 | Schering Corporation | Polycyclic quinoline, naphthyridine and pyrazinopyridine derivatives |
US5439916A (en) * | 1985-06-13 | 1995-08-08 | Schering Corporation | Polycyclic quinoline, naphthyridine and pyrazinopyridine derivatives |
US4810708A (en) * | 1986-05-15 | 1989-03-07 | Schering Corporation | Polycyclic quinoline, naphthyridine and pyrazinopyridine derivatives |
WO2004035581A1 (en) * | 2002-10-18 | 2004-04-29 | Ono Pharmaceutical Co., Ltd. | Spiroheterocyclic derivative compounds and drugs comprising the compounds as the active ingredient |
EP3375784A1 (en) * | 2017-03-14 | 2018-09-19 | Artax Biopharma Inc. | Aza-dihydro-acridone derivatives |
EP3595659A4 (en) * | 2017-03-14 | 2020-10-07 | Artax Biopharma Inc. | Aza-dihydro-acridone derivatives |
US11434239B2 (en) | 2017-03-14 | 2022-09-06 | Artax Biopharma Inc. | Aza-dihydro-acridone derivatives |
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