JPS5612393A - Novel camptothecin derivative - Google Patents

Novel camptothecin derivative

Info

Publication number
JPS5612393A
JPS5612393A JP8641279A JP8641279A JPS5612393A JP S5612393 A JPS5612393 A JP S5612393A JP 8641279 A JP8641279 A JP 8641279A JP 8641279 A JP8641279 A JP 8641279A JP S5612393 A JPS5612393 A JP S5612393A
Authority
JP
Japan
Prior art keywords
camptothecin derivative
formula
carboxylic acid
acyl group
novel camptothecin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP8641279A
Other languages
Japanese (ja)
Other versions
JPS6242913B2 (en
Inventor
Sada Miyasaka
Masahiko Mutai
Seigo Sawada
Kenichiro Nogata
Hisao Hagiwara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yakult Honsha Co Ltd
Original Assignee
Yakult Honsha Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yakult Honsha Co Ltd filed Critical Yakult Honsha Co Ltd
Priority to JP8641279A priority Critical patent/JPS5612393A/en
Priority to US06/166,953 priority patent/US4399282A/en
Priority to AU60273/80A priority patent/AU536181B2/en
Priority to IT23348/80A priority patent/IT1199976B/en
Priority to GB8022438A priority patent/GB2056973B/en
Priority to CH5265/80A priority patent/CH648316A5/en
Priority to DE19803026172 priority patent/DE3026172A1/en
Priority to NLAANVRAGE8003988,A priority patent/NL188219C/en
Priority to ES493287A priority patent/ES493287A0/en
Priority to FR8015418A priority patent/FR2462437A1/en
Priority to AR281720A priority patent/AR228575A1/en
Publication of JPS5612393A publication Critical patent/JPS5612393A/en
Priority to ES499986A priority patent/ES499986A0/en
Priority to ES499987A priority patent/ES499987A0/en
Priority to US06/676,248 priority patent/USRE32518E/en
Publication of JPS6242913B2 publication Critical patent/JPS6242913B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:The titled compound of the formula (R1 is CH2OR3 or COOR4; R3 is acyl group; R4 is H or lower alkyl group; R2 is H or acyl group).
EXAMPLE: 20-O-Acetyl-7-acetoxymethylcamptothecin.
USE: A medicine having a carcinostatic activity and an intermediate therefor.
PROCESS: 7-Hydroxymethylcamptothecin is acylated with an acylating agent, e.g. a carboxylic acid halide, which is a reactive derivative of a carboxylic acid and capable of acylating the hydroxyl group, to give a compound of the formula. Pyridine or sulfuric acid may be used as a catalyst for the acylation.
COPYRIGHT: (C)1981,JPO&Japio
JP8641279A 1979-07-10 1979-07-10 Novel camptothecin derivative Granted JPS5612393A (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
JP8641279A JPS5612393A (en) 1979-07-10 1979-07-10 Novel camptothecin derivative
US06/166,953 US4399282A (en) 1979-07-10 1980-07-08 Camptothecin derivatives
AU60273/80A AU536181B2 (en) 1979-07-10 1980-07-09 Derivatives of camptothecin
IT23348/80A IT1199976B (en) 1979-07-10 1980-07-09 CAMPTOTECIMA DERIVATIVES AND PROCESSES FOR THEIR PREPARATION
GB8022438A GB2056973B (en) 1979-07-10 1980-07-09 Camptothecin derivatives useful as antitumour agents
CH5265/80A CH648316A5 (en) 1979-07-10 1980-07-09 CAMPTOTHECINE DERIVATIVES AND METHOD FOR THEIR PRODUCTION.
NLAANVRAGE8003988,A NL188219C (en) 1979-07-10 1980-07-10 CAMPHOTHECIN DERIVATIVES, METHOD FOR PREPARING THE SAME, PHARMACEUTICAL PREPARATIONS WITH ANTI-TUMOR EFFECTS, METHOD FOR PREPARING THEREOF
DE19803026172 DE3026172A1 (en) 1979-07-10 1980-07-10 CAMPTOTHECINE DERIVATIVES AND THEIR PRODUCTION
ES493287A ES493287A0 (en) 1979-07-10 1980-07-10 A PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF CAMPTO TECINA.
FR8015418A FR2462437A1 (en) 1979-07-10 1980-07-10 NEW CAMPTOTHECINE DERIVATIVES WITH ANTI-TUMOR ACTIVITY AND PROCESS FOR THEIR PREPARATION
AR281720A AR228575A1 (en) 1979-07-10 1980-07-10 PROCEDURE FOR OBTAINING DERIVATIVES OF 7-HYDROXIMETIL OR 7-CARBOXICAMPTOTECINA AND ITS SALTS
ES499986A ES499986A0 (en) 1979-07-10 1981-03-02 A PROCEDURE FOR THE PREPARATION OF CAMPTO-TECINA DERIVATIVES
ES499987A ES499987A0 (en) 1979-07-10 1981-03-02 A PROCEDURE FOR THE PREPARATION OF CAMPTO-TECINA DERIVATIVES
US06/676,248 USRE32518E (en) 1979-07-10 1984-11-29 Camptothecin derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8641279A JPS5612393A (en) 1979-07-10 1979-07-10 Novel camptothecin derivative

Publications (2)

Publication Number Publication Date
JPS5612393A true JPS5612393A (en) 1981-02-06
JPS6242913B2 JPS6242913B2 (en) 1987-09-10

Family

ID=13886146

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8641279A Granted JPS5612393A (en) 1979-07-10 1979-07-10 Novel camptothecin derivative

Country Status (1)

Country Link
JP (1) JPS5612393A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005536464A (en) * 2002-05-06 2005-12-02 ザ ステーリン ファンデーション フォー キャンサー リサーチ Haloalkyl esters of camptothecin and methods of cancer treatment using these compounds

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03104504A (en) * 1989-09-14 1991-05-01 Tanaka Kikinzoku Kogyo Kk Drill with chip breaker

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005536464A (en) * 2002-05-06 2005-12-02 ザ ステーリン ファンデーション フォー キャンサー リサーチ Haloalkyl esters of camptothecin and methods of cancer treatment using these compounds

Also Published As

Publication number Publication date
JPS6242913B2 (en) 1987-09-10

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