JPS5746967A - Novel mandelic 3-hydroxy-1,2-diazine-6-yl-thiol ester and its preparation - Google Patents
Novel mandelic 3-hydroxy-1,2-diazine-6-yl-thiol ester and its preparationInfo
- Publication number
- JPS5746967A JPS5746967A JP12171980A JP12171980A JPS5746967A JP S5746967 A JPS5746967 A JP S5746967A JP 12171980 A JP12171980 A JP 12171980A JP 12171980 A JP12171980 A JP 12171980A JP S5746967 A JPS5746967 A JP S5746967A
- Authority
- JP
- Japan
- Prior art keywords
- hydroxy
- diazine
- preparation
- mandelic
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Cephalosporin Compounds (AREA)
Abstract
NEW MATERIAL:Mandelic 3-hydroxy-1,2-diazin-6-yl-thiol ester of formula I.
USE: An acylating agent for amines and hydrazines. Especially, they are very useful as an active ester in the synthesis of cephalosporins, for example, enabling easy synthesis of 7-mandelamide-3-(3-hydroxy-1,2-diazin-6-yl)tiomethyl-3-cephem-4-carboxylic acid, which is used as an antibiotic having excellent antibacterial activity against gram-positive and -negative bacteria.
PREPARATION: The reaction of 3-hydroxy-1,2-diazine-6-thiol of formula II or its reactive derivative with mandelic acid or ts derivative is effected in a solvent such as acetone at -50W100°C, preferably -20W50°C to give the compound of formula I.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12171980A JPS5746967A (en) | 1980-09-04 | 1980-09-04 | Novel mandelic 3-hydroxy-1,2-diazine-6-yl-thiol ester and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12171980A JPS5746967A (en) | 1980-09-04 | 1980-09-04 | Novel mandelic 3-hydroxy-1,2-diazine-6-yl-thiol ester and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5746967A true JPS5746967A (en) | 1982-03-17 |
Family
ID=14818179
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12171980A Pending JPS5746967A (en) | 1980-09-04 | 1980-09-04 | Novel mandelic 3-hydroxy-1,2-diazine-6-yl-thiol ester and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5746967A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU587974B2 (en) * | 1984-03-29 | 1989-09-07 | Biochemie Gesellschaft Mbh | Process for preparation of cephalosporins |
-
1980
- 1980-09-04 JP JP12171980A patent/JPS5746967A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU587974B2 (en) * | 1984-03-29 | 1989-09-07 | Biochemie Gesellschaft Mbh | Process for preparation of cephalosporins |
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