IE42179L - Kanamycin derivatives - Google Patents
Kanamycin derivativesInfo
- Publication number
- IE42179L IE42179L IE752502A IE250275A IE42179L IE 42179 L IE42179 L IE 42179L IE 752502 A IE752502 A IE 752502A IE 250275 A IE250275 A IE 250275A IE 42179 L IE42179 L IE 42179L
- Authority
- IE
- Ireland
- Prior art keywords
- formula
- acylating agent
- meaning stated
- kanamycin
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Semisynthetic derivatives of kanamycin A and B of the formula IV in which R3 and R have the meaning stated in Claim 1 are prepared. The process starts from corresponding compounds with R = hydrogen and comprises acylation with an acylating agent of the formula VII in which W and M have the meaning stated in Claim 1, and subsequent elimination of the amino protective group W. A preferred acylating agent of the formula VIIa is obtained in situ by mixing the appropriate N-protected carboxylic acid with equimolar amounts of N-hydroxy-5-norbornene-2,3-dicarboximide and dicyclohexylcarbodiimide as dehydrating agent. The said compounds have antibacterial activity and can therefore be used in medicines or as additives to animal feedstuffs. <IMAGE>
[GB1535215A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53078774A | 1974-12-09 | 1974-12-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE42179L true IE42179L (en) | 1976-06-09 |
| IE42179B1 IE42179B1 (en) | 1980-06-18 |
Family
ID=24114972
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE2502/75A IE42179B1 (en) | 1974-12-09 | 1975-11-17 | Kanamycin derivatives |
Country Status (17)
| Country | Link |
|---|---|
| JP (1) | JPS51105036A (en) |
| BE (1) | BE836292A (en) |
| CA (1) | CA1052780A (en) |
| CH (1) | CH621558A5 (en) |
| CS (1) | CS191168B2 (en) |
| DE (1) | DE2555405A1 (en) |
| DK (1) | DK149775B (en) |
| FR (1) | FR2293941A1 (en) |
| GB (1) | GB1535215A (en) |
| HU (1) | HU175575B (en) |
| IE (1) | IE42179B1 (en) |
| LU (1) | LU73957A1 (en) |
| NL (1) | NL7514322A (en) |
| SE (1) | SE435513B (en) |
| SU (1) | SU581873A3 (en) |
| YU (1) | YU306475A (en) |
| ZA (1) | ZA757652B (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2860513D1 (en) * | 1977-06-24 | 1981-04-09 | Scherico Ltd | Process for preparing aminoglycoside derivatives, novel derivatives obtained and pharmaceutical compositions containing such derivatives |
| ES2613936T3 (en) | 2007-11-21 | 2017-05-29 | Achaogen, Inc. | Antibacterial aminoglycoside analogues |
| WO2010132768A1 (en) | 2009-05-15 | 2010-11-18 | Achaogen, Inc. | Antibacterial derivatives of sisomicin |
| WO2010132759A1 (en) | 2009-05-15 | 2010-11-18 | Achaogen, Inc. | Antibacterial derivatives of dibekacin |
| WO2010132765A2 (en) | 2009-05-15 | 2010-11-18 | Achaogen, Inc. | Antibacterial aminoglycoside analogs |
| WO2010132757A2 (en) * | 2009-05-15 | 2010-11-18 | Achaogen, Inc. | Antibacterial aminoglycoside analogs |
| WO2010132760A1 (en) | 2009-05-15 | 2010-11-18 | Achaogen, Inc. | Antibacterial derivatives of tobramycin |
| EP2616079B1 (en) | 2010-09-13 | 2015-10-14 | University of Zürich | Treatment of bacterial infectious diseases |
| WO2018004994A1 (en) | 2016-07-01 | 2018-01-04 | Res Usa, Llc | Fluidized bed membrane reactor |
| US9981896B2 (en) | 2016-07-01 | 2018-05-29 | Res Usa, Llc | Conversion of methane to dimethyl ether |
| US10189763B2 (en) | 2016-07-01 | 2019-01-29 | Res Usa, Llc | Reduction of greenhouse gas emission |
-
1975
- 1975-11-17 CA CA239,778A patent/CA1052780A/en not_active Expired
- 1975-11-17 IE IE2502/75A patent/IE42179B1/en unknown
- 1975-12-01 GB GB49224/75A patent/GB1535215A/en not_active Expired
- 1975-12-04 FR FR7537162A patent/FR2293941A1/en active Granted
- 1975-12-04 BE BE162464A patent/BE836292A/en not_active IP Right Cessation
- 1975-12-05 YU YU03064/75A patent/YU306475A/en unknown
- 1975-12-05 DK DK551075AA patent/DK149775B/en unknown
- 1975-12-05 ZA ZA757652A patent/ZA757652B/en unknown
- 1975-12-08 HU HU75BI532A patent/HU175575B/en unknown
- 1975-12-08 JP JP50145206A patent/JPS51105036A/en active Pending
- 1975-12-08 CH CH1593175A patent/CH621558A5/en not_active IP Right Cessation
- 1975-12-08 LU LU73957A patent/LU73957A1/xx unknown
- 1975-12-08 SE SE7513804A patent/SE435513B/en unknown
- 1975-12-09 SU SU7502195304A patent/SU581873A3/en active
- 1975-12-09 DE DE19752555405 patent/DE2555405A1/en not_active Withdrawn
- 1975-12-09 CS CS758365A patent/CS191168B2/en unknown
- 1975-12-09 NL NL7514322A patent/NL7514322A/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DK149775B (en) | 1986-09-29 |
| SU581873A3 (en) | 1977-11-25 |
| AU8688275A (en) | 1977-06-02 |
| CS191168B2 (en) | 1979-06-29 |
| DE2555405A1 (en) | 1976-06-10 |
| IE42179B1 (en) | 1980-06-18 |
| FR2293941B1 (en) | 1978-11-10 |
| SE435513B (en) | 1984-10-01 |
| CH621558A5 (en) | 1981-02-13 |
| LU73957A1 (en) | 1976-11-11 |
| HU175575B (en) | 1980-09-28 |
| DK551075A (en) | 1976-06-10 |
| JPS51105036A (en) | 1976-09-17 |
| SE7513804L (en) | 1976-06-10 |
| ZA757652B (en) | 1976-11-24 |
| GB1535215A (en) | 1978-12-13 |
| FR2293941A1 (en) | 1976-07-09 |
| CA1052780A (en) | 1979-04-17 |
| BE836292A (en) | 1976-06-04 |
| YU306475A (en) | 1982-05-31 |
| NL7514322A (en) | 1976-06-11 |
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