GB1535215A - Kanamycin derivatives - Google Patents

Kanamycin derivatives

Info

Publication number
GB1535215A
GB1535215A GB49224/75A GB4922475A GB1535215A GB 1535215 A GB1535215 A GB 1535215A GB 49224/75 A GB49224/75 A GB 49224/75A GB 4922475 A GB4922475 A GB 4922475A GB 1535215 A GB1535215 A GB 1535215A
Authority
GB
United Kingdom
Prior art keywords
formula
acylating agent
meaning stated
kanamycin
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB49224/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of GB1535215A publication Critical patent/GB1535215A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Semisynthetic derivatives of kanamycin A and B of the formula IV in which R3 and R have the meaning stated in Claim 1 are prepared. The process starts from corresponding compounds with R = hydrogen and comprises acylation with an acylating agent of the formula VII in which W and M have the meaning stated in Claim 1, and subsequent elimination of the amino protective group W. A preferred acylating agent of the formula VIIa is obtained in situ by mixing the appropriate N-protected carboxylic acid with equimolar amounts of N-hydroxy-5-norbornene-2,3-dicarboximide and dicyclohexylcarbodiimide as dehydrating agent. The said compounds have antibacterial activity and can therefore be used in medicines or as additives to animal feedstuffs. <IMAGE>
GB49224/75A 1974-12-09 1975-12-01 Kanamycin derivatives Expired GB1535215A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53078774A 1974-12-09 1974-12-09

Publications (1)

Publication Number Publication Date
GB1535215A true GB1535215A (en) 1978-12-13

Family

ID=24114972

Family Applications (1)

Application Number Title Priority Date Filing Date
GB49224/75A Expired GB1535215A (en) 1974-12-09 1975-12-01 Kanamycin derivatives

Country Status (17)

Country Link
JP (1) JPS51105036A (en)
BE (1) BE836292A (en)
CA (1) CA1052780A (en)
CH (1) CH621558A5 (en)
CS (1) CS191168B2 (en)
DE (1) DE2555405A1 (en)
DK (1) DK149775B (en)
FR (1) FR2293941A1 (en)
GB (1) GB1535215A (en)
HU (1) HU175575B (en)
IE (1) IE42179B1 (en)
LU (1) LU73957A1 (en)
NL (1) NL7514322A (en)
SE (1) SE435513B (en)
SU (1) SU581873A3 (en)
YU (1) YU306475A (en)
ZA (1) ZA757652B (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8383596B2 (en) 2007-11-21 2013-02-26 Achaogen, Inc. Antibacterial aminoglycoside analogs
US8492354B2 (en) 2009-05-15 2013-07-23 Achaogen, Inc. Antibacterial aminoglycoside analogs
US8524675B2 (en) 2009-05-15 2013-09-03 Achaogen, Inc. Antibacterial aminoglycoside analogs
US8524689B2 (en) 2009-05-15 2013-09-03 Achaogen, Inc. Antibacterial aminoglycoside analogs
US8653042B2 (en) 2009-05-15 2014-02-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
US8658606B2 (en) 2009-05-15 2014-02-25 Achaogen, Inc. Antibacterial aminoglycoside analogs

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2860513D1 (en) * 1977-06-24 1981-04-09 Scherico Ltd Process for preparing aminoglycoside derivatives, novel derivatives obtained and pharmaceutical compositions containing such derivatives
CN111481562A (en) 2010-09-13 2020-08-04 苏黎世大学 Application of apramycin in preparation of bacterial infectious disease treatment
US9938217B2 (en) 2016-07-01 2018-04-10 Res Usa, Llc Fluidized bed membrane reactor
WO2018004992A1 (en) 2016-07-01 2018-01-04 Res Usa, Llc Conversion of methane to dimethyl ether
WO2018004993A1 (en) 2016-07-01 2018-01-04 Res Usa, Llc Reduction of greenhouse gas emission

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8383596B2 (en) 2007-11-21 2013-02-26 Achaogen, Inc. Antibacterial aminoglycoside analogs
US8822424B2 (en) 2007-11-21 2014-09-02 Achaogen, Inc. Antibacterial aminoglycoside analogs
US9266919B2 (en) 2007-11-21 2016-02-23 Achaogen, Inc. Antibacterial aminoglycoside analogs
US9688711B2 (en) 2007-11-21 2017-06-27 Achaogen, Inc. Antibacterial aminoglycoside analogs
US11117915B2 (en) 2007-11-21 2021-09-14 Cipla USA, Inc. Antibacterial aminoglycoside analogs
US8492354B2 (en) 2009-05-15 2013-07-23 Achaogen, Inc. Antibacterial aminoglycoside analogs
US8524675B2 (en) 2009-05-15 2013-09-03 Achaogen, Inc. Antibacterial aminoglycoside analogs
US8524689B2 (en) 2009-05-15 2013-09-03 Achaogen, Inc. Antibacterial aminoglycoside analogs
US8653042B2 (en) 2009-05-15 2014-02-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
US8658606B2 (en) 2009-05-15 2014-02-25 Achaogen, Inc. Antibacterial aminoglycoside analogs
USRE47741E1 (en) 2009-05-15 2019-11-26 Achaogen, Inc. Antibacterial aminoglycoside analogs

Also Published As

Publication number Publication date
NL7514322A (en) 1976-06-11
SE7513804L (en) 1976-06-10
IE42179B1 (en) 1980-06-18
AU8688275A (en) 1977-06-02
CH621558A5 (en) 1981-02-13
JPS51105036A (en) 1976-09-17
LU73957A1 (en) 1976-11-11
HU175575B (en) 1980-09-28
DK149775B (en) 1986-09-29
SE435513B (en) 1984-10-01
CS191168B2 (en) 1979-06-29
IE42179L (en) 1976-06-09
DK551075A (en) 1976-06-10
BE836292A (en) 1976-06-04
DE2555405A1 (en) 1976-06-10
FR2293941B1 (en) 1978-11-10
CA1052780A (en) 1979-04-17
FR2293941A1 (en) 1976-07-09
ZA757652B (en) 1976-11-24
SU581873A3 (en) 1977-11-25
YU306475A (en) 1982-05-31

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee