JPS57144255A - Alpha-methylthio(1-alkyl-2-pyrrolyl)acetamide derivative - Google Patents
Alpha-methylthio(1-alkyl-2-pyrrolyl)acetamide derivativeInfo
- Publication number
- JPS57144255A JPS57144255A JP2938581A JP2938581A JPS57144255A JP S57144255 A JPS57144255 A JP S57144255A JP 2938581 A JP2938581 A JP 2938581A JP 2938581 A JP2938581 A JP 2938581A JP S57144255 A JPS57144255 A JP S57144255A
- Authority
- JP
- Japan
- Prior art keywords
- methylthio
- pyrrolyl
- alkyl
- derivative
- acetamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pyrrole Compounds (AREA)
Abstract
NEW MATERIAL:The α-methylthio(1-alkyl-2-pyrrolyl)acetamide derivative of formulaI(R is lower alkyl; Y is H or methylthio; R1 and R2 are methyl or together with N atom form a ring).
EXAMPLE: N,N-Dimethyl-α-methylthio(1-methyl-2-pyrrolyl)acetamide.
USE: Raw material of tolmetin useful as an antiphlogistic agent and analgesic agent.
PROCESS: The compound of formulaIwherein Y is methylthio can be prepared e.g. by (1) reacting the 1-alkylpyrrole with the acid chloride of formula III, and (2) reacting the resultant (1-alkyl-2-pyrrolyl)glyoxylic acid amide derivative of formula IV with emthanethiol or its active derivative in the presence of a Lewis acid catalyst. The product can be converted to another compound of formulaIwherein Y is H by the reducive desulfurization.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2938581A JPS57144255A (en) | 1981-03-03 | 1981-03-03 | Alpha-methylthio(1-alkyl-2-pyrrolyl)acetamide derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2938581A JPS57144255A (en) | 1981-03-03 | 1981-03-03 | Alpha-methylthio(1-alkyl-2-pyrrolyl)acetamide derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS57144255A true JPS57144255A (en) | 1982-09-06 |
Family
ID=12274664
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2938581A Pending JPS57144255A (en) | 1981-03-03 | 1981-03-03 | Alpha-methylthio(1-alkyl-2-pyrrolyl)acetamide derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS57144255A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012077221A1 (en) * | 2010-12-10 | 2012-06-14 | アグロカネショウ株式会社 | 3-aminooxalylaminobenzamide derivative, and insecticidal and acaricidal agent containing same as active ingredient |
| US8993574B2 (en) | 2008-04-24 | 2015-03-31 | F2G Ltd | Pyrrole antifungal agents |
| US10201524B2 (en) | 2014-11-21 | 2019-02-12 | F2G Limited | Antifungal agents |
| US10973821B2 (en) | 2016-05-25 | 2021-04-13 | F2G Limited | Pharmaceutical formulation |
| US11819503B2 (en) | 2019-04-23 | 2023-11-21 | F2G Ltd | Method of treating coccidioides infection |
-
1981
- 1981-03-03 JP JP2938581A patent/JPS57144255A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8993574B2 (en) | 2008-04-24 | 2015-03-31 | F2G Ltd | Pyrrole antifungal agents |
| US9452168B2 (en) | 2008-04-24 | 2016-09-27 | F2G Ltd | Pyrrole antifungal agents |
| WO2012077221A1 (en) * | 2010-12-10 | 2012-06-14 | アグロカネショウ株式会社 | 3-aminooxalylaminobenzamide derivative, and insecticidal and acaricidal agent containing same as active ingredient |
| US10201524B2 (en) | 2014-11-21 | 2019-02-12 | F2G Limited | Antifungal agents |
| US10596150B2 (en) | 2014-11-21 | 2020-03-24 | F2G Limited | Antifungal agents |
| US11065228B2 (en) | 2014-11-21 | 2021-07-20 | F2G Limited | Antifungal agents |
| US10973821B2 (en) | 2016-05-25 | 2021-04-13 | F2G Limited | Pharmaceutical formulation |
| US11819503B2 (en) | 2019-04-23 | 2023-11-21 | F2G Ltd | Method of treating coccidioides infection |
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