JPS5612394A - Novel camptothecin derivative - Google Patents
Novel camptothecin derivativeInfo
- Publication number
- JPS5612394A JPS5612394A JP8641379A JP8641379A JPS5612394A JP S5612394 A JPS5612394 A JP S5612394A JP 8641379 A JP8641379 A JP 8641379A JP 8641379 A JP8641379 A JP 8641379A JP S5612394 A JPS5612394 A JP S5612394A
- Authority
- JP
- Japan
- Prior art keywords
- derivative
- hydroxycamptothecin
- formula
- camptothecin derivative
- novel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:The titled compound of the formula (R1 is lower alkyl or acyl group; R2 is H or acyl group).
EXAMPLE: 5-Methoxycamptothecin.
USE: A medicine having a carcinostatic activity and an intermediate therefor.
PROCESS: The hydroxyl group of novel 5-hydroxycamptothecin is alkylated or acylated to form the compound of the formula. In alkylation, the 5-hydroxycamptothecin is heated with a lower alcohol in the presence of hydrochloric or sulfuric acid as a catalyst to give the corresponding methoxy or ethoxy derivative. In acylation, a reactive derivative, of an acid, e.g. a carboxylic acid halide or anhydride, is used to form an acyl derivative.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8641379A JPS5612394A (en) | 1979-07-10 | 1979-07-10 | Novel camptothecin derivative |
US06/166,953 US4399282A (en) | 1979-07-10 | 1980-07-08 | Camptothecin derivatives |
CH5265/80A CH648316A5 (en) | 1979-07-10 | 1980-07-09 | CAMPTOTHECINE DERIVATIVES AND METHOD FOR THEIR PRODUCTION. |
AU60273/80A AU536181B2 (en) | 1979-07-10 | 1980-07-09 | Derivatives of camptothecin |
GB8022438A GB2056973B (en) | 1979-07-10 | 1980-07-09 | Camptothecin derivatives useful as antitumour agents |
IT23348/80A IT1199976B (en) | 1979-07-10 | 1980-07-09 | CAMPTOTECIMA DERIVATIVES AND PROCESSES FOR THEIR PREPARATION |
ES493287A ES493287A0 (en) | 1979-07-10 | 1980-07-10 | A PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF CAMPTO TECINA. |
FR8015418A FR2462437A1 (en) | 1979-07-10 | 1980-07-10 | NEW CAMPTOTHECINE DERIVATIVES WITH ANTI-TUMOR ACTIVITY AND PROCESS FOR THEIR PREPARATION |
NLAANVRAGE8003988,A NL188219C (en) | 1979-07-10 | 1980-07-10 | CAMPHOTHECIN DERIVATIVES, METHOD FOR PREPARING THE SAME, PHARMACEUTICAL PREPARATIONS WITH ANTI-TUMOR EFFECTS, METHOD FOR PREPARING THEREOF |
AR281720A AR228575A1 (en) | 1979-07-10 | 1980-07-10 | PROCEDURE FOR OBTAINING DERIVATIVES OF 7-HYDROXIMETIL OR 7-CARBOXICAMPTOTECINA AND ITS SALTS |
DE19803026172 DE3026172A1 (en) | 1979-07-10 | 1980-07-10 | CAMPTOTHECINE DERIVATIVES AND THEIR PRODUCTION |
ES499987A ES8202012A1 (en) | 1979-07-10 | 1981-03-02 | A procedure for the preparation of camptootecine derivatives (Machine-translation by Google Translate, not legally binding) |
ES499986A ES8202011A1 (en) | 1979-07-10 | 1981-03-02 | A procedure for the preparation of camptootecine derivatives (Machine-translation by Google Translate, not legally binding) |
US06/676,248 USRE32518E (en) | 1979-07-10 | 1984-11-29 | Camptothecin derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8641379A JPS5612394A (en) | 1979-07-10 | 1979-07-10 | Novel camptothecin derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5612394A true JPS5612394A (en) | 1981-02-06 |
Family
ID=13886175
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8641379A Pending JPS5612394A (en) | 1979-07-10 | 1979-07-10 | Novel camptothecin derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5612394A (en) |
-
1979
- 1979-07-10 JP JP8641379A patent/JPS5612394A/en active Pending
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