JPS5612394A - Novel camptothecin derivative - Google Patents

Novel camptothecin derivative

Info

Publication number
JPS5612394A
JPS5612394A JP8641379A JP8641379A JPS5612394A JP S5612394 A JPS5612394 A JP S5612394A JP 8641379 A JP8641379 A JP 8641379A JP 8641379 A JP8641379 A JP 8641379A JP S5612394 A JPS5612394 A JP S5612394A
Authority
JP
Japan
Prior art keywords
derivative
hydroxycamptothecin
formula
camptothecin derivative
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP8641379A
Other languages
Japanese (ja)
Inventor
Sada Miyasaka
Masahiko Mutai
Seigo Sawada
Kenichiro Nogata
Hisao Hagiwara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yakult Honsha Co Ltd
Original Assignee
Yakult Honsha Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yakult Honsha Co Ltd filed Critical Yakult Honsha Co Ltd
Priority to JP8641379A priority Critical patent/JPS5612394A/en
Priority to US06/166,953 priority patent/US4399282A/en
Priority to CH5265/80A priority patent/CH648316A5/en
Priority to AU60273/80A priority patent/AU536181B2/en
Priority to GB8022438A priority patent/GB2056973B/en
Priority to IT23348/80A priority patent/IT1199976B/en
Priority to FR8015418A priority patent/FR2462437A1/en
Priority to ES493287A priority patent/ES493287A0/en
Priority to NLAANVRAGE8003988,A priority patent/NL188219C/en
Priority to AR281720A priority patent/AR228575A1/en
Priority to DE19803026172 priority patent/DE3026172A1/en
Publication of JPS5612394A publication Critical patent/JPS5612394A/en
Priority to ES499987A priority patent/ES8202012A1/en
Priority to ES499986A priority patent/ES8202011A1/en
Priority to US06/676,248 priority patent/USRE32518E/en
Pending legal-status Critical Current

Links

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:The titled compound of the formula (R1 is lower alkyl or acyl group; R2 is H or acyl group).
EXAMPLE: 5-Methoxycamptothecin.
USE: A medicine having a carcinostatic activity and an intermediate therefor.
PROCESS: The hydroxyl group of novel 5-hydroxycamptothecin is alkylated or acylated to form the compound of the formula. In alkylation, the 5-hydroxycamptothecin is heated with a lower alcohol in the presence of hydrochloric or sulfuric acid as a catalyst to give the corresponding methoxy or ethoxy derivative. In acylation, a reactive derivative, of an acid, e.g. a carboxylic acid halide or anhydride, is used to form an acyl derivative.
COPYRIGHT: (C)1981,JPO&Japio
JP8641379A 1979-07-10 1979-07-10 Novel camptothecin derivative Pending JPS5612394A (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
JP8641379A JPS5612394A (en) 1979-07-10 1979-07-10 Novel camptothecin derivative
US06/166,953 US4399282A (en) 1979-07-10 1980-07-08 Camptothecin derivatives
CH5265/80A CH648316A5 (en) 1979-07-10 1980-07-09 CAMPTOTHECINE DERIVATIVES AND METHOD FOR THEIR PRODUCTION.
AU60273/80A AU536181B2 (en) 1979-07-10 1980-07-09 Derivatives of camptothecin
GB8022438A GB2056973B (en) 1979-07-10 1980-07-09 Camptothecin derivatives useful as antitumour agents
IT23348/80A IT1199976B (en) 1979-07-10 1980-07-09 CAMPTOTECIMA DERIVATIVES AND PROCESSES FOR THEIR PREPARATION
ES493287A ES493287A0 (en) 1979-07-10 1980-07-10 A PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF CAMPTO TECINA.
FR8015418A FR2462437A1 (en) 1979-07-10 1980-07-10 NEW CAMPTOTHECINE DERIVATIVES WITH ANTI-TUMOR ACTIVITY AND PROCESS FOR THEIR PREPARATION
NLAANVRAGE8003988,A NL188219C (en) 1979-07-10 1980-07-10 CAMPHOTHECIN DERIVATIVES, METHOD FOR PREPARING THE SAME, PHARMACEUTICAL PREPARATIONS WITH ANTI-TUMOR EFFECTS, METHOD FOR PREPARING THEREOF
AR281720A AR228575A1 (en) 1979-07-10 1980-07-10 PROCEDURE FOR OBTAINING DERIVATIVES OF 7-HYDROXIMETIL OR 7-CARBOXICAMPTOTECINA AND ITS SALTS
DE19803026172 DE3026172A1 (en) 1979-07-10 1980-07-10 CAMPTOTHECINE DERIVATIVES AND THEIR PRODUCTION
ES499987A ES8202012A1 (en) 1979-07-10 1981-03-02 A procedure for the preparation of camptootecine derivatives (Machine-translation by Google Translate, not legally binding)
ES499986A ES8202011A1 (en) 1979-07-10 1981-03-02 A procedure for the preparation of camptootecine derivatives (Machine-translation by Google Translate, not legally binding)
US06/676,248 USRE32518E (en) 1979-07-10 1984-11-29 Camptothecin derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8641379A JPS5612394A (en) 1979-07-10 1979-07-10 Novel camptothecin derivative

Publications (1)

Publication Number Publication Date
JPS5612394A true JPS5612394A (en) 1981-02-06

Family

ID=13886175

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8641379A Pending JPS5612394A (en) 1979-07-10 1979-07-10 Novel camptothecin derivative

Country Status (1)

Country Link
JP (1) JPS5612394A (en)

Similar Documents

Publication Publication Date Title
JPS55164687A (en) Novel maytansinoid compound and its preparation
JPS55164685A (en) Novel maytansinoid compound and its preparation
JPS5432460A (en) Cycloalkylidenemethylphenylacetic acid derivative and their preparation
JPS57116074A (en) Novel camptothecin derivative and its preparation
JPS5612394A (en) Novel camptothecin derivative
JPS6492A (en) Novel glycerin derivative, production thereof, hypotensor containing said derivative
JPS5612393A (en) Novel camptothecin derivative
JPS5576852A (en) Novel derivative of anthranilic acid
JPS57200355A (en) 2-mercaptopropionic acid and its preparation
JPS54151985A (en) Preparation of aminocarbostyril derivative
JPS5589245A (en) 9,10-dihydroanthracene-2-alkanoic acid derivative
JPS5686165A (en) Pyrazolidin-3-one derivative and its preparation
JPS55115895A (en) Glucosamine derivative and its preparation
JPS54160381A (en) Tetrazolylcoumarin
JPS54122281A (en) 5-fluorouracil derivative and its preparation
JPS55102548A (en) Nitrosamine derivative
JPS5476513A (en) Polyprenyl alcohol ester and hypotensives containing it
JPS5448717A (en) Nitrosourea compounds and their preparation
JPS5484557A (en) Novel halogeno-acetanilide derivative and its preparation
JPS5618985A (en) Furoindole compound
JPS57181033A (en) Novel cyclohexanecarboxylic acid derivative
JPS56167635A (en) Alpha,beta-dihydropolyprenylcarboxylic acid and its derivative
JPS5210219A (en) Preparation of beta-sulfonylacrylic beta-sulfonylacrylic their esters and acids their esters and amides
JPS5543049A (en) Pyrido (3,2,1-jk) carbazole derivative
JPS5531087A (en) Preparation of 5-acetyl-1,2,6-trimethyl-tricyclo 5.3.2.02,7 dodec-5-ene