JPS56167635A - Alpha,beta-dihydropolyprenylcarboxylic acid and its derivative - Google Patents
Alpha,beta-dihydropolyprenylcarboxylic acid and its derivativeInfo
- Publication number
- JPS56167635A JPS56167635A JP7148880A JP7148880A JPS56167635A JP S56167635 A JPS56167635 A JP S56167635A JP 7148880 A JP7148880 A JP 7148880A JP 7148880 A JP7148880 A JP 7148880A JP S56167635 A JPS56167635 A JP S56167635A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- derivative
- acid
- compound expressed
- expressed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:An α,β-dihydropolyprenyl-carboxylic acid expressed by formula I (n is an integer 1W4; R1 is H or lower alkyl) and its derivative.
EXAMPLE: (E,E)-3,7,11,15-Tetramethyl-6,10,14-hexadecatetraenoic acid.
USE: A treating agent for hepatic disorders, preferably per os usually in an amount of 50W2,000mg, preferably 200W600mg, per adult a day.
PROCESS: A compound expressed by formula II is hydrolyzed in the presence of a base, to form a compound expressed by formula III. The resultant compound or a reactive derivative, if necessary, is reacted with a compound expressed by the formula R3-OH (R3 is lower alkyl) to give a compound expressed by formula I. The compound expressed by formula III, if used, is reacted in the presence of a condensing agent, e.g. p-toluenesulfonyl chloride, or in the case of a reactive derivative, an acid chloride or an acid anhydride may be cited as a preferable derivative.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7148880A JPS56167635A (en) | 1980-05-30 | 1980-05-30 | Alpha,beta-dihydropolyprenylcarboxylic acid and its derivative |
EP83107281A EP0098620B1 (en) | 1980-05-30 | 1981-05-27 | Alpha,beta-dihydropolyprenyl derivatives and a process for preparing these derivatives |
DE8181104084T DE3168876D1 (en) | 1980-05-30 | 1981-05-27 | Alpha,beta-dihydropolyprenyl derivatives for treating liver diseases |
EP81104084A EP0041235B1 (en) | 1980-05-30 | 1981-05-27 | Alpha,beta-dihydropolyprenyl derivatives for treating liver diseases |
DE8383107281T DE3175360D1 (en) | 1980-05-30 | 1981-05-27 | Alpha,beta-dihydropolyprenyl derivatives and a process for preparing these derivatives |
US06/269,930 US4481217A (en) | 1980-05-30 | 1981-05-28 | α,β-Dihydropolyprenyl derivatives useful in treating hepatitis |
US06/543,748 US4571408A (en) | 1980-05-30 | 1983-10-20 | α,β-Dihydropolyprenyl derivatives for treating hepatitis |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7148880A JPS56167635A (en) | 1980-05-30 | 1980-05-30 | Alpha,beta-dihydropolyprenylcarboxylic acid and its derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS56167635A true JPS56167635A (en) | 1981-12-23 |
JPS6332059B2 JPS6332059B2 (en) | 1988-06-28 |
Family
ID=13462085
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP7148880A Granted JPS56167635A (en) | 1980-05-30 | 1980-05-30 | Alpha,beta-dihydropolyprenylcarboxylic acid and its derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56167635A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5962522A (en) * | 1982-08-09 | 1984-04-10 | ザ・リ−ジエンツ・オブ・ザ・ユニバ−シテイ・オブ・カリフオルニア | Method and composition for protecting and treating gastric duodenal mucosa and lever |
-
1980
- 1980-05-30 JP JP7148880A patent/JPS56167635A/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5962522A (en) * | 1982-08-09 | 1984-04-10 | ザ・リ−ジエンツ・オブ・ザ・ユニバ−シテイ・オブ・カリフオルニア | Method and composition for protecting and treating gastric duodenal mucosa and lever |
Also Published As
Publication number | Publication date |
---|---|
JPS6332059B2 (en) | 1988-06-28 |
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