JPS5746948A - Production of beta- 1,2,2,-trifluoro-2-alkoxyethyl alanine derivative - Google Patents
Production of beta- 1,2,2,-trifluoro-2-alkoxyethyl alanine derivativeInfo
- Publication number
- JPS5746948A JPS5746948A JP12287280A JP12287280A JPS5746948A JP S5746948 A JPS5746948 A JP S5746948A JP 12287280 A JP12287280 A JP 12287280A JP 12287280 A JP12287280 A JP 12287280A JP S5746948 A JPS5746948 A JP S5746948A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- trifluoro
- alkoxyethyl
- beta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:Compounds of formula I (R is 1W4C straight or branched-chain alkyl).
EXAMPLE: 2-Acetylamino-4,5,5-trifluoro-5-ethoxypentanoic acid.
USE: Synthetic intermediate of fluorine-containing aminoacids or intermediate of medicines and agricultural chemicals.
PREPARATION: A β-trifluorovinylalanine derivative of formula II (R' is methyl, ethyl) and an alcohol of ROH are heated in the presence of a base such as potassium or sodium hydroxide and the reaction mixture is treated with an inorganic acid such as dilute hydrochloric acid to produce the compound of formula I. The reaction is effected by dissolving the compound of formula II in an excess amount of the alcohol (5W20 times the weight of the compound) and adding the base 1.5W2 times the molar amount of the compound of formula II. The objective compound is prepared readily by the one-step process.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12287280A JPS5746948A (en) | 1980-09-04 | 1980-09-04 | Production of beta- 1,2,2,-trifluoro-2-alkoxyethyl alanine derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12287280A JPS5746948A (en) | 1980-09-04 | 1980-09-04 | Production of beta- 1,2,2,-trifluoro-2-alkoxyethyl alanine derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5746948A true JPS5746948A (en) | 1982-03-17 |
JPS5748142B2 JPS5748142B2 (en) | 1982-10-14 |
Family
ID=14846711
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12287280A Granted JPS5746948A (en) | 1980-09-04 | 1980-09-04 | Production of beta- 1,2,2,-trifluoro-2-alkoxyethyl alanine derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5746948A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4511733A (en) * | 1981-12-25 | 1985-04-16 | Daikin Kogyo Co., Ltd. | Fluorine-containing aminocarboxylic acid compounds |
-
1980
- 1980-09-04 JP JP12287280A patent/JPS5746948A/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4511733A (en) * | 1981-12-25 | 1985-04-16 | Daikin Kogyo Co., Ltd. | Fluorine-containing aminocarboxylic acid compounds |
Also Published As
Publication number | Publication date |
---|---|
JPS5748142B2 (en) | 1982-10-14 |
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