JPS55167274A - Forphenicine derivative and its preparation - Google Patents
Forphenicine derivative and its preparationInfo
- Publication number
- JPS55167274A JPS55167274A JP7404779A JP7404779A JPS55167274A JP S55167274 A JPS55167274 A JP S55167274A JP 7404779 A JP7404779 A JP 7404779A JP 7404779 A JP7404779 A JP 7404779A JP S55167274 A JPS55167274 A JP S55167274A
- Authority
- JP
- Japan
- Prior art keywords
- forphenicine
- formula
- derivative
- preparation
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:A Forphenicine derivative of formula I (M is pharmacologically nontoxic cation).
EXAMPLE: The sodium bisulfite addition compound of Forphenicine.
USE: An immune remedy for cancer having improved stability in an aqueous solution, usable as an injection, and characterized by the high water-solubility of Forphenicine which is slightly soluble in water with the physiological activity maintained.
PROCESS: Forphenicine (F) of formula II is reacted with a hydrogensulfite or pyrosulfite at a temperature of -10°C to the boiling point of the reaction system, preferably about room temperature, for 10W120min to give the compound of formula I. The amount of the salt is 0.9W1.5 equivalents per mole of F.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7404779A JPS55167274A (en) | 1979-06-14 | 1979-06-14 | Forphenicine derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7404779A JPS55167274A (en) | 1979-06-14 | 1979-06-14 | Forphenicine derivative and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS55167274A true JPS55167274A (en) | 1980-12-26 |
JPS6215073B2 JPS6215073B2 (en) | 1987-04-06 |
Family
ID=13535865
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP7404779A Granted JPS55167274A (en) | 1979-06-14 | 1979-06-14 | Forphenicine derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55167274A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0850225A4 (en) * | 1994-05-20 | 1998-07-01 |
-
1979
- 1979-06-14 JP JP7404779A patent/JPS55167274A/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0850225A4 (en) * | 1994-05-20 | 1998-07-01 |
Also Published As
Publication number | Publication date |
---|---|
JPS6215073B2 (en) | 1987-04-06 |
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