JPS55167274A - Forphenicine derivative and its preparation - Google Patents

Forphenicine derivative and its preparation

Info

Publication number
JPS55167274A
JPS55167274A JP7404779A JP7404779A JPS55167274A JP S55167274 A JPS55167274 A JP S55167274A JP 7404779 A JP7404779 A JP 7404779A JP 7404779 A JP7404779 A JP 7404779A JP S55167274 A JPS55167274 A JP S55167274A
Authority
JP
Japan
Prior art keywords
forphenicine
formula
derivative
preparation
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP7404779A
Other languages
Japanese (ja)
Other versions
JPS6215073B2 (en
Inventor
Hamao Umezawa
Tomio Takeuchi
Takaaki Aoyanagi
Takuzou Yamamoto
Ikuo Matsumoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSD KK
Original Assignee
Banyu Phamaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Phamaceutical Co Ltd filed Critical Banyu Phamaceutical Co Ltd
Priority to JP7404779A priority Critical patent/JPS55167274A/en
Publication of JPS55167274A publication Critical patent/JPS55167274A/en
Publication of JPS6215073B2 publication Critical patent/JPS6215073B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:A Forphenicine derivative of formula I (M is pharmacologically nontoxic cation).
EXAMPLE: The sodium bisulfite addition compound of Forphenicine.
USE: An immune remedy for cancer having improved stability in an aqueous solution, usable as an injection, and characterized by the high water-solubility of Forphenicine which is slightly soluble in water with the physiological activity maintained.
PROCESS: Forphenicine (F) of formula II is reacted with a hydrogensulfite or pyrosulfite at a temperature of -10°C to the boiling point of the reaction system, preferably about room temperature, for 10W120min to give the compound of formula I. The amount of the salt is 0.9W1.5 equivalents per mole of F.
COPYRIGHT: (C)1980,JPO&Japio
JP7404779A 1979-06-14 1979-06-14 Forphenicine derivative and its preparation Granted JPS55167274A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP7404779A JPS55167274A (en) 1979-06-14 1979-06-14 Forphenicine derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7404779A JPS55167274A (en) 1979-06-14 1979-06-14 Forphenicine derivative and its preparation

Publications (2)

Publication Number Publication Date
JPS55167274A true JPS55167274A (en) 1980-12-26
JPS6215073B2 JPS6215073B2 (en) 1987-04-06

Family

ID=13535865

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7404779A Granted JPS55167274A (en) 1979-06-14 1979-06-14 Forphenicine derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS55167274A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0850225A4 (en) * 1994-05-20 1998-07-01

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0850225A4 (en) * 1994-05-20 1998-07-01

Also Published As

Publication number Publication date
JPS6215073B2 (en) 1987-04-06

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