JPS57116035A - Novel benzylideneaminocarboxylic acid derivative and its preparation - Google Patents
Novel benzylideneaminocarboxylic acid derivative and its preparationInfo
- Publication number
- JPS57116035A JPS57116035A JP179081A JP179081A JPS57116035A JP S57116035 A JPS57116035 A JP S57116035A JP 179081 A JP179081 A JP 179081A JP 179081 A JP179081 A JP 179081A JP S57116035 A JPS57116035 A JP S57116035A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- benzylideneaminocarboxylic
- novel
- preparation
- acid derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:A compound of formulaI(X1 is hydroxyl or methoxyl; X2 is H or medicinally acceptable metal; m is an integer 2 or 3).
EXAMPLE: N-( 3, 4-Dehydeoxybenzylidene )aminomethyl-cis-cyclohexanecarboxylic acid.
USE: Useful as a remedy for various diseases, e.g. thrombosis or cerebral hemorrhage or an intermediate therefor, and having inhibitory action on blood platelet aggregation, and/or inhibitory action on leukocytotaxia with low toxicity.
PROCESS: A compound of formula II, e.g. hydroxybenzaldehyde, is condensed with a cis-or trans-aminomethylcyclohexancecarboxylic acid of formula III and a salt or an alkyl ester thereof in an organic solvent through dehydration to give the compound of formulaI.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP179081A JPS57116035A (en) | 1981-01-09 | 1981-01-09 | Novel benzylideneaminocarboxylic acid derivative and its preparation |
US06/267,249 US4377594A (en) | 1980-06-04 | 1981-05-26 | Derivative of 4-(N-(substituted-benzylidene)amino-methyl cyclohexane-1-carboxylic acid |
AU71168/81A AU542972B2 (en) | 1980-06-04 | 1981-05-29 | 4-(n-(substituted-benzylidene)aminomethyl)cyclohexane-1- carboxylic acids |
NO811887A NO152252C (en) | 1980-06-04 | 1981-06-03 | ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY EFFECTIVE DERIVATIVES OF 4- (N- (SUBSTITUTED-BENZYLIDE) AMINOMETHYL) -CYCLOHEXAN-1-CARBOXYLIC ACID |
DE8181302466T DE3161771D1 (en) | 1980-06-04 | 1981-06-03 | 4-(n-(substituted-benzylidene)aminomethyl)cyclohexane-1-carboxylic acids |
CA000378938A CA1183150A (en) | 1980-06-04 | 1981-06-03 | Derivative of 4-[n-(substituted- benzylidene)aminomethyl]cyclohexane-1-carboxylic acid |
EP81302466A EP0041826B1 (en) | 1980-06-04 | 1981-06-03 | 4-(n-(substituted-benzylidene)aminomethyl)cyclohexane-1-carboxylic acids |
DK248181A DK149769C (en) | 1980-06-04 | 1981-06-04 | METHOD OF ANALOGY FOR THE PREPARATION OF TRANS-4- (N- (SUBSTITUTED-BENZYLIDE) AMINOMETHYL) -CYCLOHEXAN-1-CARBOXYLIC ACID AND DERIVATIVES THEREOF |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP179081A JPS57116035A (en) | 1981-01-09 | 1981-01-09 | Novel benzylideneaminocarboxylic acid derivative and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57116035A true JPS57116035A (en) | 1982-07-19 |
Family
ID=11511364
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP179081A Pending JPS57116035A (en) | 1980-06-04 | 1981-01-09 | Novel benzylideneaminocarboxylic acid derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57116035A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0585130A3 (en) * | 1992-08-27 | 1994-06-08 | Shiseido Co Ltd | External preparation for skin containing a depigmentation agent |
-
1981
- 1981-01-09 JP JP179081A patent/JPS57116035A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0585130A3 (en) * | 1992-08-27 | 1994-06-08 | Shiseido Co Ltd | External preparation for skin containing a depigmentation agent |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS5432460A (en) | Cycloalkylidenemethylphenylacetic acid derivative and their preparation | |
JPS5690031A (en) | Preparation of aromatic aldehyde | |
JPS57106638A (en) | Conjugated polyprenylcarboxylic acid and its derivative | |
JPS57116035A (en) | Novel benzylideneaminocarboxylic acid derivative and its preparation | |
JPS57118555A (en) | Leucotriene-analog compound, its preparation, and leucotriene-biosynthesis inhibiting agent containing said compound as active component | |
JPS57159777A (en) | 4-hydroxycyclopentenone compound and its preparation | |
JPS5716852A (en) | Nitrile derivative, its preparation, and fibrosis suppressing agent containing the same | |
JPS5528955A (en) | Novel glycerophosphoric acid derivative, its salt, their preparation, and carcinostatic agent containing the same. | |
JPS57192340A (en) | Isoprenylamine derivative | |
JPS5616489A (en) | Imidazolecarboxylic acid derivative | |
JPS5566592A (en) | 7-alkoxythiazolo 3,2-a pyrimidine derivative, its preparation, and drug containing the same | |
JPS54100333A (en) | Benzyl alcohol derivative and its preparation | |
JPS5732260A (en) | Mercaptofatty acid derivative and its preparation | |
JPS5679668A (en) | 1,4-dihydro-4-oxonicotinic acid derivatice and its preparation | |
JPS57122041A (en) | Phenylclohexane derivative | |
JPS5543034A (en) | Thiazolidine-2-carboxylic acid derivative and agricultural and horticultural fungicide containing the same | |
JPS55147278A (en) | Nicotinoylaminotriazine derivative | |
JPS51122043A (en) | Process for preparation of 3-hydroxy-5- cycloxycyclopento-1-ene deriva tives | |
JPS5359656A (en) | Silacyclopropene derivatives and process for preparation of the same | |
JPS57106633A (en) | 1-halogeno-5-hydroxy-6-methylene-2-heptanol, its derivative and their preparation | |
JPS5422354A (en) | 2-chloro-2-cyano-7-aklylbicyclo-(2.2.1)heptane and its preparation | |
JPS57140781A (en) | Preparation of dibenzoxepine compound | |
JPS54145615A (en) | Derivative of (1,3)-beta-d-glucane, its use and preparation | |
JPS5422353A (en) | 2-chloro-2-cyano-7-alkylidene-bicyclo(2,2,1)-5-heptene and its preparation | |
JPS5515407A (en) | 2-phenyl substituted 1-phthalazone derivative |