JPS5714588A - 1- tetrahydro-4-pyridyl -2-substituted-quinazolin-4-one derivative and its preparation - Google Patents
1- tetrahydro-4-pyridyl -2-substituted-quinazolin-4-one derivative and its preparationInfo
- Publication number
- JPS5714588A JPS5714588A JP8917980A JP8917980A JPS5714588A JP S5714588 A JPS5714588 A JP S5714588A JP 8917980 A JP8917980 A JP 8917980A JP 8917980 A JP8917980 A JP 8917980A JP S5714588 A JPS5714588 A JP S5714588A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- expressed
- tetrahydro
- pyridyl
- quinazolin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:A 1-(tetrahydro-4-pyridyl)-2-substituted-quinazolin-4-one derivative expressed by formula I (R is lower alkyl or aryl).
EXAMPLE: 1-(1-Benzyl-1, 2, 5, 6-tetrahydro-4-pyridyl)-2-methyl-1, 4-dihydroquinazolin-4-one.
USE: A medicine having, anti-inflammatory and antihistaminic action.
PROCESS: A 1-benzylspiro [ piperidine-4, 2'-(1',2',3',4'-tetrahydroquinazolin ) ] -4'- one is reacted with an anhydride of a carboxylic acid expressed by the formula R- COOH, e.g. acetic anhydride or benzoic anhydride, to give the compound expressed by formula I. The reaction is carried out in the presence of a deacidifying agent, e.g. pyridine, at 100W150°C for several hours. The acyl substitution reaction occurs on the N atom at the 3-position of the quinazoline nucleus expressed by formula II, and then the acyl group is rearranged to afford the compound expressed by formul a I.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8917980A JPS5714588A (en) | 1980-07-02 | 1980-07-02 | 1- tetrahydro-4-pyridyl -2-substituted-quinazolin-4-one derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8917980A JPS5714588A (en) | 1980-07-02 | 1980-07-02 | 1- tetrahydro-4-pyridyl -2-substituted-quinazolin-4-one derivative and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5714588A true JPS5714588A (en) | 1982-01-25 |
Family
ID=13963526
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8917980A Pending JPS5714588A (en) | 1980-07-02 | 1980-07-02 | 1- tetrahydro-4-pyridyl -2-substituted-quinazolin-4-one derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5714588A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004035581A1 (en) * | 2002-10-18 | 2004-04-29 | Ono Pharmaceutical Co., Ltd. | Spiroheterocyclic derivative compounds and drugs comprising the compounds as the active ingredient |
CN100432059C (en) * | 2002-10-11 | 2008-11-12 | 诺瓦提斯公司 | Quinazolinone derivatives useful as anti-hyperalgesic agents |
-
1980
- 1980-07-02 JP JP8917980A patent/JPS5714588A/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100432059C (en) * | 2002-10-11 | 2008-11-12 | 诺瓦提斯公司 | Quinazolinone derivatives useful as anti-hyperalgesic agents |
WO2004035581A1 (en) * | 2002-10-18 | 2004-04-29 | Ono Pharmaceutical Co., Ltd. | Spiroheterocyclic derivative compounds and drugs comprising the compounds as the active ingredient |
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