JPS5714588A - 1- tetrahydro-4-pyridyl -2-substituted-quinazolin-4-one derivative and its preparation - Google Patents

1- tetrahydro-4-pyridyl -2-substituted-quinazolin-4-one derivative and its preparation

Info

Publication number
JPS5714588A
JPS5714588A JP8917980A JP8917980A JPS5714588A JP S5714588 A JPS5714588 A JP S5714588A JP 8917980 A JP8917980 A JP 8917980A JP 8917980 A JP8917980 A JP 8917980A JP S5714588 A JPS5714588 A JP S5714588A
Authority
JP
Japan
Prior art keywords
formula
expressed
tetrahydro
pyridyl
quinazolin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP8917980A
Other languages
Japanese (ja)
Inventor
Masatoshi Yamato
Jiro Horiuchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KANTO ISHI PHARMA CO Ltd
Original Assignee
KANTO ISHI PHARMA CO Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KANTO ISHI PHARMA CO Ltd filed Critical KANTO ISHI PHARMA CO Ltd
Priority to JP8917980A priority Critical patent/JPS5714588A/en
Publication of JPS5714588A publication Critical patent/JPS5714588A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:A 1-(tetrahydro-4-pyridyl)-2-substituted-quinazolin-4-one derivative expressed by formula I (R is lower alkyl or aryl).
EXAMPLE: 1-(1-Benzyl-1, 2, 5, 6-tetrahydro-4-pyridyl)-2-methyl-1, 4-dihydroquinazolin-4-one.
USE: A medicine having, anti-inflammatory and antihistaminic action.
PROCESS: A 1-benzylspiro [ piperidine-4, 2'-(1',2',3',4'-tetrahydroquinazolin ) ] -4'- one is reacted with an anhydride of a carboxylic acid expressed by the formula R- COOH, e.g. acetic anhydride or benzoic anhydride, to give the compound expressed by formula I. The reaction is carried out in the presence of a deacidifying agent, e.g. pyridine, at 100W150°C for several hours. The acyl substitution reaction occurs on the N atom at the 3-position of the quinazoline nucleus expressed by formula II, and then the acyl group is rearranged to afford the compound expressed by formul a I.
COPYRIGHT: (C)1982,JPO&Japio
JP8917980A 1980-07-02 1980-07-02 1- tetrahydro-4-pyridyl -2-substituted-quinazolin-4-one derivative and its preparation Pending JPS5714588A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP8917980A JPS5714588A (en) 1980-07-02 1980-07-02 1- tetrahydro-4-pyridyl -2-substituted-quinazolin-4-one derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8917980A JPS5714588A (en) 1980-07-02 1980-07-02 1- tetrahydro-4-pyridyl -2-substituted-quinazolin-4-one derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS5714588A true JPS5714588A (en) 1982-01-25

Family

ID=13963526

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8917980A Pending JPS5714588A (en) 1980-07-02 1980-07-02 1- tetrahydro-4-pyridyl -2-substituted-quinazolin-4-one derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5714588A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004035581A1 (en) * 2002-10-18 2004-04-29 Ono Pharmaceutical Co., Ltd. Spiroheterocyclic derivative compounds and drugs comprising the compounds as the active ingredient
CN100432059C (en) * 2002-10-11 2008-11-12 诺瓦提斯公司 Quinazolinone derivatives useful as anti-hyperalgesic agents

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100432059C (en) * 2002-10-11 2008-11-12 诺瓦提斯公司 Quinazolinone derivatives useful as anti-hyperalgesic agents
WO2004035581A1 (en) * 2002-10-18 2004-04-29 Ono Pharmaceutical Co., Ltd. Spiroheterocyclic derivative compounds and drugs comprising the compounds as the active ingredient

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