JPS5649360A - 2-oxoquinoline derivative - Google Patents
2-oxoquinoline derivativeInfo
- Publication number
- JPS5649360A JPS5649360A JP12556579A JP12556579A JPS5649360A JP S5649360 A JPS5649360 A JP S5649360A JP 12556579 A JP12556579 A JP 12556579A JP 12556579 A JP12556579 A JP 12556579A JP S5649360 A JPS5649360 A JP S5649360A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- lower alkyl
- compound
- oxoquinoline
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:A 2-oxoquinoline derivative of formula I (R0 is H or lower alkyl; R1 is H, lower alkyl, lower alkenyl, lower alkynyl, or phenulalkyl; R2 is lower alkyl; R3 is halogen, phenyl or phenylalkyl; X and Q are halogen; Y is lower alkylene; Z is -N= or -CH=; n is 0W2; the bond between the 3-and the 4-carbon atoms of the 2-oxoquinoline skeleton is single or double bond).
EXAMPLE: 4-Phenyl-1-[ 3-( 2-oxo-1, 2, 3, 4-tetrahydroquinolin-7-yloxy )propyl ]-1- methyl-piperazinium iodide.
USE: An antihistaminic agent for the remedy of allergic rhinitis, etc. and a central nervous system depressant useful as a preoperative medicine.
PROCESS: The compound of formula I is prepared by reacting a novel compound of formula II with a compound of formula R2O.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (22)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12556579A JPS5649360A (en) | 1979-09-28 | 1979-09-28 | 2-oxoquinoline derivative |
DE19803034237 DE3034237A1 (en) | 1979-09-18 | 1980-09-11 | CARBOSTYRIL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND ANTIHISTAMINICALLY ACTIVE AGENTS CONTAINING THESE COMPOUNDS |
FR8019708A FR2465732A1 (en) | 1979-09-18 | 1980-09-12 | NOVEL CARBOSTYRILE DERIVATIVES, PROCESS FOR PREPARING THEM AND THEIR THERAPEUTIC APPLICATION |
AU62381/80A AU518144B2 (en) | 1979-09-18 | 1980-09-12 | Process |
FI802905A FI76322C (en) | 1979-09-18 | 1980-09-16 | Process for the preparation of novel, therapeutically useful carboxylic acid derivatives |
SU802982853A SU1091857A3 (en) | 1979-09-18 | 1980-09-16 | Process for preparing derivatives of carbostyrene or their pharmaceutically acceptable acid addition salts |
NLAANVRAGE8005188,A NL187912C (en) | 1979-09-18 | 1980-09-17 | PHARMACEUTICAL PREPARATION CONTAINING A CARBOSTYRIL DERIVATIVE AND CARBOSTYRIL DERIVATIVE SUBSTITUTED BY A (1-PIPERIDYL) ALKOXY GROUP. |
CA000360402A CA1151172A (en) | 1979-09-18 | 1980-09-17 | 3-piperidinopropoxy carbostyril derivatives |
NO802762A NO154841C (en) | 1979-09-18 | 1980-09-17 | ANALOGUE PROCEDURE FOR THE PREPARATION OF PHARMACOLOGICALLY ACTIVE CARBO STYRIC DERIVATIVES. |
SE8006498A SE439632B (en) | 1979-09-18 | 1980-09-17 | CARBOSTYRIL DERIVATIVES, PROCEDURE FOR PREPARING IT AND ANTIHISTAMINE AGENTS |
CH694080A CH645892A5 (en) | 1979-09-18 | 1980-09-17 | CARBOSTYRIL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND ANTIHISTAMINICALLY ACTIVE AGENTS CONTAINING THESE COMPOUNDS. |
AT0465780A AT376972B (en) | 1979-09-18 | 1980-09-17 | METHOD FOR PRODUCING NEW CARBOSTYRILE DERIVATIVES AND ACID ADDITIONAL SALTS AND QUATERNAUS SALTS HIEVON AND THEIR OPTICAL ISOMERS |
DK394080A DK158984C (en) | 1979-09-18 | 1980-09-17 | ANALOGY PROCEDURE FOR THE PREPARATION OF CARBOSTYRIC DERIVATIVES |
PT71810A PT71810B (en) | 1979-09-18 | 1980-09-17 | Carbostyril derivatives process for producing thereof and antihistaminic agents containing the same |
AR282565A AR230280A1 (en) | 1979-09-18 | 1980-09-17 | PROCEDURE FOR OBTAINING CARBOESTIRILE DERIVATIVES AND THEIR SALTS |
ES495163A ES495163A0 (en) | 1979-09-18 | 1980-09-18 | A PROCEDURE FOR THE PREPARATION OF CARBOESTIRILE DERIVATIVES. |
MX809034U MX6806E (en) | 1979-09-18 | 1980-09-18 | PROCEDURE FOR PRODUCING CARBOESTIRILE DERIVATIVES |
IT68445/80A IT1129263B (en) | 1979-09-18 | 1980-09-18 | CARBOSTYRILIC DERIVATIVES PROCEDURE FOR THEIR PREPARATION AND ANTIHISTAMINIC PRODUCTS CONTAINING SUCH DERIVATIVES |
GB8030207A GB2063869B (en) | 1979-09-18 | 1980-09-18 | Carbostyril derivatives processes for their production and antihistaminic agents containing them |
US06/357,769 US4482560A (en) | 1979-09-18 | 1982-03-12 | Carbostyril derivatives, and antihistaminic agents containing the same |
AR289431A AR230059A1 (en) | 1979-09-18 | 1982-05-18 | PROCEDURE FOR OBTAINING DERIVATIVES OF PIPERIDIL-1-IL-ALCOXI OR HIDROXIALCOXI-CARBOESTIRILO OR 3,4-DIHIDROCARBOESTIRILO |
AT68884A AT376973B (en) | 1979-09-18 | 1984-02-29 | METHOD FOR PRODUCING NEW CARBOSTYRILE DERIVATIVES AND ACID ADDITIONAL SALTS AND QUATERNAUS SALTS HIEVON AND THEIR OPTICAL ISOMERS |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12556579A JPS5649360A (en) | 1979-09-28 | 1979-09-28 | 2-oxoquinoline derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5649360A true JPS5649360A (en) | 1981-05-02 |
JPS6254304B2 JPS6254304B2 (en) | 1987-11-13 |
Family
ID=14913332
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12556579A Granted JPS5649360A (en) | 1979-09-18 | 1979-09-28 | 2-oxoquinoline derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5649360A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007191495A (en) * | 2001-10-22 | 2007-08-02 | Santen Pharmaceut Co Ltd | Pruritus treating agent |
-
1979
- 1979-09-28 JP JP12556579A patent/JPS5649360A/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007191495A (en) * | 2001-10-22 | 2007-08-02 | Santen Pharmaceut Co Ltd | Pruritus treating agent |
Also Published As
Publication number | Publication date |
---|---|
JPS6254304B2 (en) | 1987-11-13 |
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